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  1. Zhang W, Du FY, Dai Y, Zheng JC
    Phys Chem Chem Phys, 2023 Feb 08.
    PMID: 36752130 DOI: 10.1039/d2cp05241e
    The olivine phosphate family has been widely utilized as cathode materials for high-performance lithium-ion batteries. However, limited energy density and poor rate performance caused by low electronic and ionic conductivities are the main obstacles that need to be overcome for their widespread application. In this work, atomic simulations have been performed to study the effects of lattice strains on the Li+ ion migration energy barrier in olivine phosphates LiMPO4 (M = Mn, Fe, Co) and (LiFePO4)n(LiMnPO4)m superlattices (SLs). The (LiFePO4)n(LiMnPO4)m superlattices include three ratios of LFP/LMP, namely SL3 + 1, SL1 + 1 and SL1 + 3, each of which is along three typical (100), (010) and (001) orientations. We mainly discuss two migration paths of Li+ ions: the low-energy path A channel parallel to the b-axis and the medium-energy path B channel parallel to the c-axis. It is found that the biaxial tensile strain perpendicular to the migration path is most beneficial to reduce the migration energy barrier of Li+ ions, and the strain on the b-axis has a dominant effect on the energy barrier of Li+ ion migration. For path A, SL3 + 1 alternating periodically along the (010) orientation can obtain the lowest Li ion migration energy barrier. For path B, SL1 + 3 is the most favorable for Li+ ion migration, and there is no significant difference among the three orientations. Our work provides reference values for cathode materials and battery design.
  2. Yang M, Mohammad Yusoff WF, Mohamed MF, Jiao S, Dai Y
    J Environ Manage, 2024 Feb;351:119798.
    PMID: 38103426 DOI: 10.1016/j.jenvman.2023.119798
    With climate change and urbanization, flood disasters have significantly affected urban development worldwide. In this study, we developed a paradigm to assess flood economic vulnerability and risk at the urban mesoscale, focusing on urban land use. A hydrological simulation was used to evaluate flood hazards through inundation analyses, and a hazard-vulnerability matrix was applied to assess flood risk, enhancing the economic vulnerability assessment by quantifying the differing economic value and flood losses associated with different land types. The case study of Wangchengpo, Changsha, China, found average total economic losses of 126.94 USD/m2, with the highest risk in the settlement core. Residential areas had the highest flood hazard, vulnerability, and losses (61.10% of the total loss); transportation areas accounted for 27.87% of the total economic losses due to their high flooding depth. Despite low inundation, industrial land showed greater economic vulnerability due to higher overall economic value (10.52% of the total). Our findings highlight the influence of land types and industry differences on flood vulnerability and the effectiveness of land-use inclusion in urban-mesoscale analyses of spatial flood characteristics. We identify critical areas with hazard and economic vulnerability for urban land and disaster prevention management and planning, helping to offer targeted flood control strategies to enhance urban resilience.
  3. Dai Y, Han L, Wang Y, Zhao K, Gu J, Bai H, et al.
    Leg Med (Tokyo), 2023 Nov;65:102303.
    PMID: 37598646 DOI: 10.1016/j.legalmed.2023.102303
    Nimetazepam (marketed brand names; Erimin and Lavol) is an intermediate acting benzodiazepine derivative, which was widely used mainly in East and Southeast Asian region countries including Japan, Malaysia, Brunei, the Philippines, Thailand, Indonesia, Hong Kong, Singapore and China. Nimetazepam and its metabolite 7-aminonimetazepam were quantified from human hair samples by liquid chromatography tandem-mass spectrometry (LC-MS/MS), under selective reaction monitoring mode. Using diazepam-d5 as an internal standard, the concentration of nimetazepam and its metabolite 7-aminonimetazepam could be determined by matrix matched calibration method. Extraction of the target compounds was performed by using methanol, followed by evaporation and being concentrated with nitrogen. The Limit of quantification concentrations of nimetazepam and its metabolite 7-aminonimetazepam in hair samples were both 25 pg/mg by established method. The concentrations of nimetazepam in hair samples obtained from 2 users were 27.4, and 22.0 pg/mg, respectively; the concentrations of 7-animonimetazepam in hair samples were 54.2 and 29.1 pg/mg, respectively. In our study, the 7-aminonimetazepam concentrations in hair was higher than those of nimetazepam in the authentic hair samples. To our knowledge, this is the first report to establish the detailed procedure for quantificating nimetazepam and 7-aminonimetazepam in human hair by LC-MS/MS.
  4. Chung E, Hui J, Xin ZC, Kim SW, Moon DG, Yuan Y, et al.
    World J Mens Health, 2023 Oct 16.
    PMID: 37853539 DOI: 10.5534/wjmh.230180
    Male infertility (MI) and male sexual dysfunction (MSD) can often coexist together due to various interplay factors such as psychosexual, sociocultural and relationship dynamics. The presence of each form of MSD can adversely impact male reproduction and treatment strategies will need to be individualized based on patients' factors, local expertise, and geographical socioeconomic status. The Asia Pacific Society of Sexual Medicine (APSSM) and the Asian Society of Men's Health and Aging (ASMHA) aim to provide a consensus statement and practical set of clinical recommendations based on current evidence to guide clinicians in the management of MI and MSD within the Asia-Pacific (AP) region. A comprehensive, narrative review of the literature was performed to identify the various forms of MSD and their association with MI. MEDLINE and EMBASE databases were searched for the following English language articles under the following terms: "low libido", "erectile dysfunction", "ejaculatory dysfunction", "premature ejaculation", "retrograde ejaculation", "delayed ejaculation", "anejaculation", and "orgasmic dysfunction" between January 2001 to June 2022 with emphasis on published guidelines endorsed by various organizations. This APSSM consensus committee panel evaluated and provided evidence-based recommendations on MI and clinically relevant MSD areas using a modified Delphi method by the panel and specific emphasis on locoregional socio-economic-cultural issues relevant to the AP region. While variations exist in treatment strategies for managing MI and MSD due to geographical expertise, locoregional resources, and sociocultural factors, the panel agreed that comprehensive fertility evaluation with a multidisciplinary management approach to each MSD domain is recommended. It is important to address individual MI issues with an emphasis on improving spermatogenesis and facilitating reproductive avenues while at the same time, managing various MSD conditions with evidence-based treatments. All therapeutic options should be discussed and implemented based on the patient's individual needs, beliefs and preferences while incorporating locoregional expertise and available resources.
  5. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
    Autophagy, 2021 Jan;17(1):1-382.
    PMID: 33634751 DOI: 10.1080/15548627.2020.1797280
    In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
  6. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, et al.
    Autophagy, 2016;12(1):1-222.
    PMID: 26799652 DOI: 10.1080/15548627.2015.1100356
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