MyMedR

Oral status of Singapore youths

Goh SW

Dent J Malaysia Singapore, 1968 Oct;8(2):19-25.

PMID: 4388033

Dental caries among day creche children in Singapore

Goh SW, Lim KA

Dent J Malaysia Singapore, 1971 Apr;11(1):13-5.

PMID: 4256479

National dental health survey of school population in Singapore dental caries

Goh SW, Wong MQ, Chan J

Dent J Malaysia Singapore, 1972 May;12(1):15-21.

PMID: 4507354

Fulltext A randomized half-body, double blind, controlled trial on the effects of a pH-modified moisturizer vs. standard moisturizer in mild to moderate atopic dermatitis

Goh SW, Jamil A, Safian N, Md Nor N, Muhammad N, Saharudin NL

An Bras Dermatol, 2020 03 21;95(3):320-325.

PMID: 32291095 DOI: 10.1016/j.abd.2019.11.007

BACKGROUND: Higher skin pH in atopic dermatitis contributes to impaired epidermal barrier. A moisturizer compatible with physiological pH could improve atopic dermatitis.

OBJECTIVE: To determine the effect of a physiologically compatible pH moisturizer in atopic dermatitis.

METHODS: A randomized half body, double blind, controlled trial involving patients with stable atopic dermatitis was performed. pH-modified moisturizer and standard moisturizer were applied to half body for 6 weeks.

RESULTS: A total of 6 (16.7%) males and 30 (83.3%) females participated. Skin pH reductions from week 0, week 2 and 6 were significant at the forearms (5.315 [0.98] to 4.85 [0.54] to 5.04 [0.78], p=0.02) and abdomen (5.25 [1.01], 4.82 [0.64], 5.01 [0.59], p=0.00) but not at the shins (5.01 [0.80], 4.76 [0.49], 4.85 [0.79], p=0.09) with pH-modified moisturizer. Transepidermal water loss (TEWL) at the forearms decreased (4.60 [2.55] to 3.70 [3.10] to 3.00 [3.55], p=0.00), abdomen (3.90 [2.90] to 2.40 [3.45] to 2.70 [2.25], p=0.046). SCORAD improved from 14.1±12.75 to 10.5±13.25 to 7±12.25, p=0.00. In standard moisturizer group, pH reductions were significant at the forearms (5.29 [0.94] to 4.84 [0.55] to 5.02 [0.70], p=0.00) and abdomen (5.25 [1.09], 4.91 [0.63], 5.12 [0.66], p=0.00). TEWL at the forearm were (4.80 [2.95], 4.10 [2.15], 4.60 [3.40], p=0.67), shins (3.80 [1.40], 3.50 [2.35], 4.00 [2.50], p=0.91) and abdomen (3.70 [2.45], 4.10 [3.60], 3.40 [2.95], p=0.80). SCORAD improved from 14.2±9.1 to 10.9±10.65 to 10.5±11, p=0.00. Reduction in pH was observed with both moisturizers while TEWL significantly improved with pH-modified moisturizer. pH-modified moisturizer resulted in greater pH, TEWL and SCORAD improvements however the differences were not significant from standard moisturizer.

STUDY LIMITATION: Skin hydration was not evaluated.

CONCLUSION: Moisturization is beneficial for atopic dermatitis; use of physiologically compatible pH moisturizer is promising.

Skin eruption induced by dieting - an underdiagnosed skin disease in Malaysia

Goh SW, Adawiyah J, Md Nor N, Yap F, Ch'ng P, Chang CC

Malays Fam Physician, 2019;14(1):42-46.

PMID: 31289632

Prurigo pigmentosa is an inflammatory dermatosis characterized by a pruritic, symmetrically distributed erythematous papular or papulo-vesicular eruption on the trunk arranged in a reticulated pattern that resolves with hyperpigmentation. It is typically non-responsive to topical or systemic steroid therapy. The exact etiology is unknown, but it is more commonly described in the Far East countries. Dietary change is one of the predisposing factors. We report on nine young adult patients with prurigo pigmentosa, among whom five were on ketogenic diets prior to the onset of the eruptions. All cases resolved with oral doxycycline with no recurrence. We hope to improve the awareness of this uncommon skin condition among general practitioners and physicians so that disfiguring hyperpigmentation due to delayed diagnosis and treatment can be avoided.

Fulltext Exacerbation of systemic lupus erythematosus in a patient with concomitant chronic plaque psoriasis treated with ustekinumab

Goh SW, Jamil A, Nor NM, Cader RA, Shaharir SS

Indian J Dermatol Venereol Leprol, 2019 12 12;86(1):68-70.

PMID: 31823905 DOI: 10.4103/ijdvl.IJDVL_961_18

Sulfonated magnetic multi-walled carbon nanotubes with enhanced bonding stability, high adsorption performance, and reusability for water remediation

Lim CC, Shuit SH, Ng QH, Rahim SKEA, Hoo PY, Yeoh WM, et al.

Environ Sci Pollut Res Int, 2023 Mar;30(14):40242-40259.

PMID: 36604398 DOI: 10.1007/s11356-022-25064-4

In view of the simple and rapid conveniency of magnetic separation, magnetic nanocomposites had notably gained attention from researchers for environmental field applications. In this work, carboxylated magnetic multi-walled carbon nanotubes (c-MMWCNTs) and novel sulfonated MMWCNTs (s-MMWCNTs) were synthesized by a facile solvent-free direct doping method. Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscope, energy dispersive X-ray, vibrating sample magnetometer, and point of zero charge analyses confirmed the successful doping of the Fe3O4 nanoparticles into the functionalized MWCNTs to form MMWCNTs. Besides, the bonding stabilities of both c-MMWCNTs and s-MMWCNTs were compared, and results showed that s-MMWCNTs possessed more substantial bonding stability than that of c-MMWCNTs with significantly less leaching amount of Fe3O4. The adsorption capacity of s-MMWCNTs was higher than that of c-MMWCNTs owing to the stronger electronegativity sulfonic group in s-MMWCNTs. Moreover, the reusability experiments proved that the adsorbent remained consistently excellent MB removal efficiency (R > 94%) even reused for twelve cycles of batch adsorption. The finding of the present work highlights the simple fabrication of novel s-MMWCNTs and its potential to be served as a promising and sustainable adsorbent for water remediation owing to its enhanced bonding stability, high adsorption performance, magnetic separability, and supreme recyclability.

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