METHODS: The rats were segregated into five groups that included normal control, 3,2'-dimethyl4amino biphenyl (DMAB) treated, DMAB + curcumin treated, DMAB + resveratrol treated and DMAB + curcumin + resveratrol treated.
RESULTS: The DMAB treatment resulted in a significant increase in the levels of lipid peroxidation [LPO] in DMAB treated rats. Also, significant changes were recorded in the enzyme activities of both drug metabolizing enzyme and antioxidant enzymes after DMAB treatment. Further, radiorespirometric studies showed a significant increase in the 14C-glucose turnover as well as 14C-gulcose uptake in the prostate slices of DMAB treated rats. Moreover, a significant rise in the cell proliferation was confirmed indirectly by enhanced uptake of 3H-thymidine in the prostate slices of DMAB treated rats. Interestingly, combined treatment of curcumin and resveratrol to DMAB treated animals resulted in a significant decrease in lipid peroxidation, 14C glucose uptakes/turnover and 3H-thymidine uptake in the DMAB treated rats. Besides this, curcumin and resveratrol in combination significantly modulated biochemical indices including drug-metabolizing enzymes; antioxidant enzymes in DMBA treated rats.
CONCLUSION: The study, therefore, concludes that the combination of curcumin and resveratrol holds strong modulatory potential against prostate carcinogenesis.