METHODS: In order to solve this problem, this paper proposes an end-to-end framework based on BERT for NER and RE tasks in electronic medical records. Our framework first integrates NER and RE tasks into a unified model, adopting an end-to-end processing manner, which removes the limitation and error propagation of multiple independent steps in traditional methods. Second, by pre-training and fine-tuning the BERT model on large-scale electronic medical record data, we enable the model to obtain rich semantic representation capabilities that adapt to the needs of medical fields and tasks. Finally, through multi-task learning, we enable the model to make full use of the correlation and complementarity between NER and RE tasks, and improve the generalization ability and effect of the model on different data sets.
RESULTS AND DISCUSSION: We conduct experimental evaluation on four electronic medical record datasets, and the model significantly out performs other methods on different datasets in the NER task. In the RE task, the EMLB model also achieved advantages on different data sets, especially in the multi-task learning mode, its performance has been significantly improved, and the ETE and MTL modules performed well in terms of comprehensive precision and recall. Our research provides an innovative solution for medical image and signal data.
RESULTS: Differences in disease outcome provided an opportunity to investigate the role of T cell immunity to FIP determined by T cell subset proliferation after stimulation with different viral antigens. Reduced total white blood cell (WBC), lymphocyte and T cell counts in blood were observed during primary acute infection for all experimental groups including cats that survived without clinical FIP. Antiviral T cell responses during early primary infection were also similar between cats that developed FIP and cats remaining healthy. Recovery of antiviral T cell responses during the later phase of acute infection was observed in a subset of cats that survived longer or resisted disease compared to cats showing rapid disease progression. More robust T cell responses at terminal time points were observed in lymph nodes compared to blood in cats that developed FIP. Cats that survived primary infection were challenged a second time to pathogenic FIPV and tested for antiviral T cell responses over a four week period. Nine of ten rechallenged cats did not develop FIP or T cell depletion and all cats demonstrated antiviral T cell responses at multiple time points after rechallenge.
CONCLUSIONS: In summary, definitive adaptive T cell responses predictive of disease outcome were not detected during the early phase of primary FIPV infection. However emergence of antiviral T cell responses after a second exposure to FIPV, implicated cellular immunity in the control of FIPV infection and disease progression. Virus host interactions during very early stages of FIPV infection warrant further investigation to elucidate host resistance to FIP.
METHODS: The PRISMA guidelines were adopted for this systematic literature review. Prominent academic databases such as Web of Science, PubMed, ProQuest, Cochrane Library, China National Knowledge Infrastructure (CNKI) and PsycINFO were searched to find eligible studies published before Aug 2021. The overall quality of the articles was checked using the "QualSyst" tool by Kmet et al.
RESULTS: From among 600 papers, 23 met the inclusion criteria and were incorporated into our systematic review. All of the studies were randomized controlled trials. The following thematic areas emerged as a result of the content analysis: study selection and design, as well as study characteristics (participants, intervention, comparisons, and outcomes).
DISCUSSION AND CONCLUSION: The literature on exercise and psychological interventions for smartphone addiction is scarce. There is a need to introduce new interventions and to validate the effectiveness of combined interventions. Our findings suggest that exercise and psychological interventions may help to reduce smartphone addiction. This combination was more effective compare to exercise or psychological intervention on mental health and addiction among university students. Future research should combine exercise and psychological interventions, focusing on university students, especially females, who are vulnerable to smartphone addiction. Further studies should focus on the cross-section of neuropsychology, cognitive psychology, and sports science to provide combined interventions in physiological and psychological direction.
SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero, identifier: CRD42021278037.