The records of the Division of Stomatology were reviewed for the incidence of adenomatoid odontogenic tumour diagnosed between 1968 and 1986. Forty-five cases were found. The prevalence of this tumour according to their age, sex, site and its distribution in the various states in Malaysia are reported. Many features were similar to previous reports of this entity. However the incidence of AOT appears to be higher among the Indians and lower in the Chinese population. It is suggested that this feature may be peculiar to Malaysians.
This paper represents a reappraisal of the gross and histological features of 45 cases of adenomatoid odontogenic tumours as observed under conventional light and fluorescence microscopy. The findings conformed largely to those of previous studies. Usage of the term adenomatoid odontogenic tumour in preference to its old name 'adenoameloblastoma' is emphasized. The differential diagnosis of this entity from the ameloblastoma and salivary gland tumours is discussed.
The prevalence rate of 749 cases of oral squamous cell carcinomas (SCC) recorded between 1978-1984 was studied. Results showed that the Indians formed the dominant group (63.8%) followed by the Malays (19.6%) and Chinese (16.6%). The peak incidences were generally located between the sixth and eighth decades. Only in the Chinese group a male preponderance was noted. In the Indians, the buccal mucosa was the most prevalent site; in the Malays and Chinese males, the gingiva and alveolus; and the Chinese female, the tongue. In all three groups, the well-differentiated SCC was the commonest type and the poorly differentiated least common.
An outbreak of infection with the Nipah virus, a novel paramyxovirus, occurred among pig farmers between September 1998 and June 1999 in Malaysia, involving 265 patients with 105 fatalities. This is a follow-up study 24 months after the outbreak. Twelve survivors (7.5%) of acute encephalitis had recurrent neurological disease (relapsed encephalitis). Of those who initially had acute nonencephalitic or asymptomatic infection, 10 patients (3.4%) had late-onset encephalitis. The mean interval between the first neurological episode and the time of initial infection was 8.4 months. Three patients had a second neurological episode. The onset of the relapsed or late-onset encephalitis was usually acute. Common clinical features were fever, headache, seizures, and focal neurological signs. Four of the 22 relapsed and late-onset encephalitis patients (18%) died. Magnetic resonance imaging typically showed patchy areas of confluent cortical lesions. Serial single-photon emission computed tomography showed the evolution of focal hyperperfusion to hypoperfusion in the corresponding areas. Necropsy of 2 patients showed changes of focal encephalitis with positive immunolocalization for Nipah virus antigens but no evidence of perivenous demyelination. We concluded that a unique relapsing and remitting encephalitis or late-onset encephalitis may result as a complication of persistent Nipah virus infection in the central nervous system.