MyMedR

Florid peripheral stigmata of staphylococcus aureus infective endocarditis

Yew KL, Razali F

Acute Card Care, 2015;17(2):32.

PMID: 26458028 DOI: 10.3109/17482941.2015.1066822

Massive coronary air embolism successfully treated with intracoronary catheter aspiration and intracoronary adenosine

Yew KL, Razali F

Int J Cardiol, 2015 Jun 1;188:56-7.

PMID: 25885752 DOI: 10.1016/j.ijcard.2015.04.040

Fulltext Leech in the Nose - an unusual cause of epistaxis

Zainuddin N, Nair P, Razali F

Malays Fam Physician, 2016;11(2-3):33-34.

PMID: 28461857

Leech is an uncommon nasal foreign body, which can cause epistaxis. It is an aquatic segmental worm living in fresh water most commonly in tropical areas. Once it is attached in the nose, it will secrete an anticoagulant enzyme named hirudin, and that will result in continuous bleeding more than from a normal wound even after it is removed. We present a case of a live leech in the nose that caused unilateral epistaxis in a patient with a recent history of jungle trekking.

Fulltext Pancreatitis and myopericarditis complication in leptospirosis infection

Yew KL, San Go C, Razali F

J Formos Med Assoc, 2015 Aug;114(8):785-6.

PMID: 24630490 DOI: 10.1016/j.jfma.2014.01.021

Fulltext Pacemaker extrusion from innocuous direct impact to the chest wall

Yew KL, Steven A, Razali F

Heart Asia, 2013;5(1):100.

PMID: 27326097 DOI: 10.1136/heartasia-2013-010355

Fulltext A Case of Actinomycosis of the Nasopharynx

Tumaisuri D, A F, Razali F, Husain S

Cureus, 2023 Sep;15(9):e45710.

PMID: 37868511 DOI: 10.7759/cureus.45710

Actinomycosis is a progressive granulomatous infection caused by the bacteria Actinomyces israelii. Classically, the three most common clinical forms are cervicofacial, thoracic, and abdominopelvic. On the contrary, nasopharyngeal actinomycosis is considered to be a rare clinical disease, and its occurrence is extremely low. The infection can take place without any preceding infection or on immunocompromised status. A 25-year-old male with no previous medical history presented with persistent nasal congestion and rhinorrhea. A nasal endoscopy examination revealed an unclearly demarcated nasopharyngeal mass, and a complete microbiology and pathology analysis showed actinomycetes colonies. After two weeks of oral Augmentin therapy, the patient's illness was completely eradicated. Diagnosis of nasopharyngeal actinomycosis is exceptionally crucial, and with early treatment of appropriate antibiotic therapy, the prognosis is excellent. Careful follow-up after adequate treatment as the possibility of frequent relapse is common.

Fulltext The entrapped and unravelled coronary wire

Yew KL, Ooi PS, Rajendran P, Razali F, Anum A, Yeo J, et al.

Med J Malaysia, 2014 Oct;69(5):224-6.

PMID: 25638236 MyJurnal

No abstract available.

Methamphetamine-associated reversible cardiomyopathy and stroke risk

Yew KL, Go CS, Razali F, Rajendran P, Ooi PS, Anum A

Eur Rev Med Pharmacol Sci, 2014;18(17):2403-4.

PMID: 25268081

Simplified feeding strategies for the fed-batch cultivation of Kluyveromyces lactis GG799 for enhanced recombinant xylanase production

Fuzi SF, Razali F, Jahim JM, Rahman RA, Illias RM

Bioprocess Biosyst Eng, 2014 Sep;37(9):1887-98.

PMID: 24633311 DOI: 10.1007/s00449-014-1163-z

A xylanase gene (xyn2) from Trichoderma reesei ATCC 58350 was previously cloned and expressed in Kluyveromyces lactis GG799. The production of the recombinant xylanase was conducted in a developed medium with an optimised batch and with fed-batches that were processed with glucose. The glucose served as a carbon source for cell growth and as an inducer for xylanase production. In a 1-L batch system, a glucose concentration of 20 g L(-1) and 80 % dissolved oxygen were found to provide the best conditions for the tested ranges. A xylanase activity of 75.53 U mL(-1) was obtained. However, in the batch mode, glucose depletions reduced the synthesis of recombinant xylanase by K. lactis GG799. To maximise the production of xylanase, further optimisation was performed using exponential feeding. We investigated the effects of various nitrogen sources combined with the carbon to nitrogen (C/N) molar ratio on the production of xylanase. Of the various nitrogen sources, yeast extract was found to be the most useful for recombinant xylanase production. The highest xylanase production (110.13 U mL(-1)) was measured at a C/N ratio of 50.08. These conditions led to a 45.8 % increase in xylanase activity compared with the batch cultures. Interestingly, the further addition of 500 g L(-1) glucose led to a 6.2-fold increase (465.07 U mL(-1)) in recombinant xylanase activity. These findings, together with those of the exponential feeding strategy, indicate that the composition of the C/N molar ratio has a substantial impact on recombinant protein production in K. lactis.

Bacterial reduction of Cr(VI) at technical scale--the Malaysian experience

Zakaria ZA, Ahmad WA, Zakaria Z, Razali F, Karim NA, Sum MM, et al.

Appl Biochem Biotechnol, 2012 Jul;167(6):1641-52.

PMID: 22350941 DOI: 10.1007/s12010-012-9608-9

The bacterial reduction of Cr(VI) from industrial wastewater was evaluated using a 2.0-m(3) bioreactor. Liquid pineapple waste was used as a nutrient for the biofilm community formed inside the bioreactor. The use of rubber wood sawdust as packing material was able to immobilize more than 10(6) CFU mL(-1) of Acinetobacter haemolyticus cells after 3 days of contact time. Complete reduction of 15-240 mg L(-1) of Cr(VI) was achieved even after 3 months of bioreactor operation. Cr(VI) was not detected in the final effluent fraction indicating complete removal of Cr from solution from the flocculation/coagulation step and the unlikely re-oxidation of Cr(III) into Cr(VI). Impatiens balsamina L. and Gomphrena globosa L. showed better growth in the presence of soil-sludge mixture compared to Coleus scutellarioides (L.) Benth. Significant amounts of Cr accumulated at different sections of the plants indicate its potential application in Cr phytoremediation effort. The bacterial-based system was also determined not to be detrimental to human health based on the low levels of Cr detected in the hair and nail samples of the plant operators. Thus, it can be said that bacterial-based Cr(VI) treatment system is a feasible alternative to the conventional system especially for lower Cr(VI) concentrations, where sludge generated can be used as growth supplement for ornamental plant as well as not detrimental to the health of the workers.

Association of coronary artery calcium score with calcification and degree of stenosis: An autopsy study

Kaur M, Rahimi R, Razali F, Mohd Noor N, Omar E, Abdul Manaf Z, et al.

Malays J Pathol, 2019 Aug;41(2):177-183.

PMID: 31427553

INTRODUCTION: Coronary artery disease (CAD) is a known cause of major cardiovascular events and calcium score (CS) has been developed as a marker of coronary atherosclerosis. Yet, the relationship between post mortem computed tomography (PMCT) CS with histologically observed calcification and the severity of coronary artery stenosis has not been widely explored and is still unclear. This study aims to determine the association between coronary artery PMCT CS with histologically observed calcification and degree of stenosis of coronary arteries in post-mortem cases.

MATERIALS & METHODS: This was a cross-sectional study involving 101 subjects recruited from the National Institute of Forensic Medicine (IPFN) Hospital Kuala Lumpur (HKL) over a period of 15 months, from December 2012 until April 2014. PMCT CS of the coronary arteries was calculated using Agatston-Janowitz score. Histological presence of calcification was observed and the degree of stenosis was calculated using an image analysis technique.

RESULTS: PMCT CS increased with increasing severity of stenosis (p<0.001). PMCT CS showed a positive correlation with the presence of calcification (r=-0.82, p<0.001).

CONCLUSION: Calcium score is strongly associated with coronary artery calcification and the degree of luminal stenosis in post mortem subjects. Thus, PMCT may be useful as a non-invasive tool in diagnosing CAD in the event that an autopsy is not possible.

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