Displaying publications 1 - 20 of 356 in total

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  1. Ho SC, Chong HY, Chaiyakunapruk N, Tangiisuran B, Jacob SA
    J Affect Disord, 2016 Mar 15;193:1-10.
    PMID: 26748881 DOI: 10.1016/j.jad.2015.12.029
    Medication non-adherence is one of the major challenges in treating patients with depression. This systematic review aims to determine the clinical and economic outcomes of non-adherence in depression.
    Matched MeSH terms: Depressive Disorder
  2. Lee KW, Ching SM, Devaraj NK, Chong SC, Lim SY, Loh HC, et al.
    PMID: 32466479 DOI: 10.3390/ijerph17113767
    Previous literature has reported that patients with diabetes in pregnancy (DIP) are at risk of developing antepartum depression but the results have been inconsistent in cohort studies. We conducted a systematic review and performed a meta-analysis to quantify the association between DIP and risk of antepartum depression in cohort studies. Medline, Cinahl, and PubMed databases were searched for studies investigating DIP involving pregnant women with pre-existing diabetes and gestational diabetes mellitus and their risk of antepartum depression that were published in journals from inception to 27 December 2019. We derived the summary estimates using a random-effects model and reported the findings as pooled relative risks (RR) and confidence interval (CI). Publication bias was assessed using a funnel plot and was quantified by Egger and Begg's tests. Ten studies, involving 71,036 pregnant women were included in this meta-analysis. The pooled RR to develop antepartum depression was (RR = 1.430, 95% CI: 1.251-1.636) among women with gestational diabetes mellitus. Combining pregnant women with pre-existing diabetes mellitus and gestational diabetes mellitus, they had a significant increased risk of developing antepartum depression (RR = 1.431, 95% CI: 1.205-1.699) compared with those without it. In comparison, we found no association between pre-existing diabetes mellitus in pregnancy (RR = 1.300, 95% CI: 0.736-2.297) and the risk of developing antepartum depression. This study has a few limitations: first, different questionnaire and cut-off points were used in evaluation of depression across the studies. Second, there was a lack of data on history of depression prior to pregnancy, which lead to confounding bias that could not be solved by this meta-analysis. Third, data were dominated by studies in Western countries; this is due to the studies from Eastern countries failing to meet our inclusion criteria for statistical analysis. Women with gestational diabetes mellitus have an increased risk of developing antepartum depression compared to those without the disease. Therefore, more attention on the mental health status should be given on pregnant women diagnosed with pre-existing diabetes mellitus and gestational diabetes mellitus.
    Matched MeSH terms: Depressive Disorder, Major*
  3. He L, Soh KL, Huang F, Khaza'ai H, Geok SK, Vorasiha P, et al.
    J Affect Disord, 2023 Jan 15;321:304-319.
    PMID: 36374719 DOI: 10.1016/j.jad.2022.10.026
    BACKGROUND: No meta-analysis has analyzed the effect of physical activity level, period of physical activity intervention, and duration of intervention, on perinatal depression. This study was to evaluate the impact of physical activity intensity, dose, period, and duration on perinatal depression.

    METHODS: The literature was searched via the PubMed, Embase, Cochrane Library, and Web of Science databases. Weighted mean difference (WMD) or the risk ratio (RR) was used as the effect indicator, and the effect size was represented by the 95 % confidence interval (CI). Subgroup analysis based on the perinatal stage, physical activity intensity, physical activity equivalent, and intervention duration was performed.

    RESULTS: Totally, 35 studies including 5084 women were included. Physical activity could reduce the incidence and severity of depression in perinatal women. Among depressed women with prenatal depression, low-intensity physical activity, with metabolic equivalents (METs)-min/week being <450, was associated with lower levels of depression. In the general population, the risk of postpartum depression was lower in the physical activity group when the duration of intervention was ≥12 weeks, being II, III stage, and ≥450 METs-min/week. Both low and moderate-intensity physical activity were beneficial to an improved depression severity among depressed women with postpartum depression, and moderate exercise intervention could decrease the risk of postpartum depression in general pregnant women.

    LIMITATIONS: Different types of physical activities may affect the effectiveness of interventions.

    CONCLUSION: Our study indicated physical activity specifically targeted at pregnant women could reduce depression risk and severity.

    Matched MeSH terms: Depressive Disorder*
  4. Ng CG, Chin SC, Yee AH, Loh HS, Sulaiman AH, Sherianne Sook Kuan W, et al.
    Malays J Med Sci, 2014 May;21(3):62-70.
    PMID: 25246837
    BACKGROUND: The Snaith-Hamilton Pleasure Scale (SHAPS) is a self-assessment scale designed to evaluate anhedonia in various psychiatric disorders. In order to facilitate its use in Malaysian settings, our current study aimed to examine the validity of a Malay-translated version of the SHAPS (SHAPS-M).
    METHODS: In this cross-sectional study, a total of 44 depressed patients and 82 healthy subjects were recruited from a university out-patient clinic. All participants were given both the Malay and English versions of the SHAPS, Fawcett-Clark Pleasure Scale (FCPS), General Health Questionnaire 12 (GHQ-12), and the Beck Depression Inventory (BDI) to assess their hedonic state, general mental health condition and levels of depression.
    RESULTS: The results showed that the SHAPS-M has impressive internal consistency (α = 0.96), concurrent validity and good parallel-form reliability (intraclass coefficient, ICC = 0.65).
    CONCLUSION: In addition to demonstrating good psychometric properties, the SHAPS-M is easy to administer. Therefore, it is a valid, reliable, and suitable questionnaire for assessing anhedonia among depressed patients in Malaysia.
    KEYWORDS: Malaysia; anhedonia; depression; neuroscience; pleasure; psychiatry; psychology; validation
    Study site: Psychiatric clinic, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia
    Matched MeSH terms: Depressive Disorder*
  5. Deva MP
    Med J Malaysia, 2006 Mar;61(1):4-6.
    PMID: 16708727
    Depression as a symptom and a disease has been recognized from antiquity. While numerous references to melancholia, illnesses of the heart broken, and delusions of guilt are found in Shakespearean literature, world literature, stories, and dramas the world over, yet the development of modern western medicine has by and large tended to ignore all things psychological in the process of disease recognition and understanding. Even the face of a depressed patient, so obvious to the initiated, is a rarely taught and recognized sign of ill health by non- psychiatrists. The long association of psychiatry with severe psychoses in the minds of medical teachers has dulled the sense of astuteness in the picking up of anxiety and depression. It has also dulled the medical profession into the delusion that mental illnesses do not occur in general hospitals. Thus the fairly large number of mental problems in every day clinical practice remains an area of darkness. In practice, the pick up rate of all mental illnesses in primary care remains very low at less than 5% of all mental illnesses while studies show that about 25% of all primary care patients have significant mental problems that necessitate their attendance in the primary care clinics.
    Matched MeSH terms: Depressive Disorder/diagnosis*; Depressive Disorder/therapy*
  6. Jobson L, Miskon N, Dalgleish T, Hitchcock C, Hill E, Golden AM, et al.
    Br J Clin Psychol, 2018 Sep;57(3):382-396.
    PMID: 29572886 DOI: 10.1111/bjc.12181
    OBJECTIVES: Distortions in autobiographical memory have been implicated in major depressive disorder (MDD). Those with MDD demonstrate a 'depressogenic' autobiographical life structure. Research has not examined how culture influences this process. We investigated whether Malay individuals (members of an interdependent culture) with MDD demonstrated a 'depressogenic' autobiographical life structure similar to that of British individuals (members of an independent culture) with MDD.

    DESIGN: A 2 (Culture; Malay, British) × 2 (Mood; depressed, control) cross-sectional design using a card sort task and self-report measures was used.

    METHODS: Malay individuals with MDD or no history of MDD completed the life-structure card-sorting task, which provided a novel method for investigating organizational structure of the life narrative. These data were compared to previously collected data in which British individuals with MDD or without MDD had completed the same task within the same experimental protocol.

    RESULTS: Pan-culturally those with MDD had greater negativity (i.e., used more negative attributes), negative redundancy (i.e., used the same negative attributes repeatedly across life chapters) and negative emodiversity (i.e., had greater variety and relative abundance of negative attributes), and reduced positive redundancy (i.e., used the same positive attributes repeatedly across chapters) in their structuring relative to controls. While the British MDD group had greater compartmentalization (i.e., the negative and positive attributes were clustered separately across different chapters) than British controls, the Malay MDD group had lower levels of compartmentalization than Malay controls.

    CONCLUSIONS: The findings suggest culture may shape aspects of the autobiographical life structure in MDD.

    PRACTITIONER POINTS: The majority of the literature investigating depression pertains to individuals from European Western cultures, despite recognition that depression ranks as one of the most debilitating diseases worldwide. This raises questions as to whether current depression models and interventions can be applied universally or whether they are limited to European Western groups. The current study found that pan-culturally those with MDD had similar structuring of their life story relative to controls. However, there were some cultural differences that need to be considered (e.g., Malay individuals provided less detailed, less elaborate and less emotionally diverse life stories and while the British MDD group had greater compartmentalization than British controls, the Malay MDD group had lower levels of compartmentalization than Malay controls). Limitations of the study included group differences in gender and mood at the time of testing. Cultural differences in the number of attributes used may have influenced findings. Only the Malay group completed the individualism-collectivism measure.

    Matched MeSH terms: Depressive Disorder, Major/ethnology*; Depressive Disorder, Major/psychology
  7. Barua A, Jacob GP, Mahmood SS
    Indian J Psychiatry, 2013 Apr;55(2):125-30.
    PMID: 23825844 DOI: 10.4103/0019-5545.111448
    BACKGROUND: The adult population often suffers from a number of physical and mental problems. This study was conducted to determine the proportion of mental illnesses in adult population visiting the outpatient departments at Dr. TMA Pai Rotary Hospital, Karkala and to study the socio-demographic correlates of psychiatric disorders.
    MATERIALS AND METHODS: A cross-sectional study was conducted during March 2004 among 193 adult individuals of 18 years and above at Dr. TMA Pai Rotary Hospital, Karkala, Karnataka. Data was analyzed by the statistical package for social sciences version 10.0 for windows and results were expressed in terms of proportions and their 95% confidence intervals (CI). Chi-square test, multiple logistic regression with adjusted odds ratio and its 95% CI.
    RESULTS: The proportion of psychiatric disorders in adult population was determined to be 39.9%. Proportion of psychiatric morbidity among males and females were 36.2 and 42.2%, respectively.
    CONCLUSION: This study revealed that socio-demographic correlates like age group of 50 years and above, unemployed or housewives, living alone, and a history of psychiatric illness in the family were independently associated with psychiatric disorders in adult population.
    KEYWORDS: Adult population; patient health questionnaire; psychiatric disorders; screening; socio-demographic correlates
    Matched MeSH terms: Depressive Disorder*
  8. Krishnaswamy S
    Med J Malaysia, 1997 Sep;52(3):222-5.
    PMID: 10968089
    Matched MeSH terms: Depressive Disorder/epidemiology*
  9. Edwards MJ, Wilson GC, Keitsch S, Soddemann M, Wilker B, Müller CP, et al.
    J Neurochem, 2022 Nov;163(4):357-369.
    PMID: 36227646 DOI: 10.1111/jnc.15708
    Major depressive disorder (MDD) is a severe disease of unknown pathogenesis with a lifetime prevalence of ~10%. Therapy requires prolonged treatment that often fails. We have previously demonstrated that ceramide levels in the blood plasma of patients and in mice with experimental MDD are increased. Neutralization of blood plasma ceramide prevented experimental MDD in mice. Mechanistically, we demonstrated that blood plasma ceramide accumulated in endothelial cells of the hippocampus, inhibited phospholipase D (PLD) and thereby decreased phosphatidic acid in the hippocampus. Here, we demonstrate that phosphatidic acid binds to and controls the activity of phosphotyrosine phosphatase (PTP1B) in the hippocampus and thus determines tyrosine phosphorylation of a variety of cellular proteins including TrkB. Injection of PLD, phosphatidic acid, or inhibition of PTP1B abrogated MDD and normalized cellular tyrosine phosphorylation, including phosphorylation of TrkB and neurogenesis in the hippocampus. Most importantly, these treatments also rapidly normalized behavior of mice with experimental MDD. Since phosphatidic acid binds to and inhibits PTP1B, the lack of phosphatidic acid results in increased activity of PTP1B and thereby in reduced tyrosine phosphorylation of TrkB and other cellular proteins. Thus, our data indicate a novel pathogenetic mechanism of and a rapidly acting targeted treatment for MDD.
    Matched MeSH terms: Depressive Disorder, Major*
  10. Harvey MB, O'connell KA, Barraza G, Riyanto A, Kurniawan N, Smith EN
    Zootaxa, 2015;4020(3):495-516.
    PMID: 26624112 DOI: 10.11646/zootaxa.4020.3.5
    We describe Cyrtodactylus psarops sp. nov. and C. semicinctus sp. nov., two new species of bent-toed geckos from montane forests in the southern Bukit Barisan Range of Sumatra, Indonesia. The new species are closely related to one another and to C. semenanjungensis, a lowland species currently known only from Peninsular Malaysia. Three characters of the new species immediately distinguish them from most congeners in the Sunda Region: they lack transversely enlarged subcaudals, have a precloacal depression, and have a greatly enlarged scale positioned at the apex of a continuous series of femoral and precloacal pore-bearing scales. They differ from one another in cephalic pattern, tuberculation of the brachium, and in numbers of cloacal tubercles, dorsal bands, and ventrals in a transverse row. The greatly enlarged scale at the apex of the precloacal pores appears to be a rare apomorphy of these two species and C. agamensis.
    Matched MeSH terms: Depressive Disorder
  11. Al Jumah K, Hassali MA, Al Qhatani D, El Tahir K
    Neuropsychiatr Dis Treat, 2014;10:2031-7.
    PMID: 25378929 DOI: 10.2147/NDT.S71697
    Several studies have investigated the factors associated with adherence to antidepressants, with inconsistent conclusions. However, no similar study has investigated this issue among patients diagnosed with major depressive disorder in Saudi Arabia. The aim of this study is to explore patients' adherence to antidepressant medications, and the factors associated with adherence.
    Matched MeSH terms: Depressive Disorder, Major
  12. Aljumah K, Ahmad Hassali A, AlQhatani S
    Neuropsychiatr Dis Treat, 2014;10:1433-8.
    PMID: 25120364 DOI: 10.2147/NDT.S67008
    Adherence to antidepressant treatment is an essential step in the management of patients with major depressive disorder, and several factors can contribute to antidepressant nonadherence. Evidence supports the hypothesis that patient treatment satisfaction will result in improved adherence; therefore, the aim of this study was to investigate the relationship between patient treatment satisfaction and adherence to antidepressants, and the role of patient beliefs toward medication in patient treatment satisfaction.
    Matched MeSH terms: Depressive Disorder, Major
  13. Charkhandeh M, Talib MA, Hunt CJ
    Psychiatry Res, 2016 05 30;239:325-30.
    PMID: 27058159 DOI: 10.1016/j.psychres.2016.03.044
    The main aim of the study was to investigate the effectiveness of two psychotherapeutic approaches, cognitive behavioral therapy (CBT) and a complementary medicine method Reiki, in reducing depression scores in adolescents. We recruited 188 adolescent patients who were 12-17 years old. Participants were randomly assigned to CBT, Reiki or wait-list. Depression scores were assessed before and after the 12 week interventions or wait-list. CBT showed a significantly greater decrease in Child Depression Inventory (CDI) scores across treatment than both Reiki (p
    Matched MeSH terms: Depressive Disorder/diagnosis; Depressive Disorder/psychology; Depressive Disorder/therapy*
  14. Park S, Hatim A, Si TM, Jeon HJ, Srisurapanont M, Bautista D, et al.
    Int J Soc Psychiatry, 2015 Dec;61(8):735-42.
    PMID: 25846010 DOI: 10.1177/0020764015577842
    Previous studies have identified the significant role of stressful life events in the onset of depressive episodes. However, there is a paucity of cross-national studies on stressful life events that precede depression.
    Matched MeSH terms: Depressive Disorder
  15. Mukhtar F, Oei TPS
    DOI: 10.2174/157340011797183201
    Transforming western technology to Eastern populations, including Malaysia, presents important implications in understanding the development, maintenance, and treatment of depression. The present paper aims to review the literature on the prevalence of depression studies in Malaysia. PsycINFO, Medline databases, local journals, and 13 published articles, were included in the current review. Findings were presented in three categories i.e., 'prevalence of depression in primary care', 'general community', and 'among clinical population'. Major limitations of previous studies were noted, and thus, problems associated with the implementation and future direction of clinical and research on depression in Malaysia, was provided. In short, the contribution of empirical research on the prevalence of depression has remained inconsistent and fragmented and it is therefore, a time to venture modification. © 2011 Bentham Science Publishers.
    Matched MeSH terms: Depressive Disorder
  16. Sharif Nia H, Rezapour M, Allen KA, Pahlevan Sharif S, Jafari A, Torkmandi H, et al.
    Asian Pac J Cancer Prev, 2019 09 01;20(9):2803-2809.
    PMID: 31554380 DOI: 10.31557/APJCP.2019.20.9.2803
    Objectives: The Center for Epidemiologic Studies Depression Scale (CES-D) was specifically created to assess
    depression in cancer patients. However, to date, the CES-D has not been validated in Farsi. Therefore, this study aimed to
    assess the psychometric properties of the CES-D in Iranian cancer patients. Methods: During a three-month period
    (October to December, 2015), a total of 380 cancer patients completed a Farsi version of the CES-D. The construct
    validity of the scale was evaluated by exploratory factor analysis. Reliability was assessed using Cronbach’s alpha
    and McDonald Omega. All of the statistical procedure were run by SPSS 22 (SPSS Inc., Chicago, IL, USA). Results:
    The construct validity of the CES-D determined three factors (somatic affect, negative affect, and positive affect),
    which explained 65.60% of the total variance. The internal consistency was greater than 0.70. Conclusion: Findings
    revealed that the Farsi version of the CES-D has acceptable validity and reliability, which can be used to measure
    depression in Iranian cancer patients.
    Matched MeSH terms: Depressive Disorder/diagnosis*; Depressive Disorder/epidemiology*; Depressive Disorder/psychology
  17. Citation: Clinical Practice Guidelines: Management of Major Depressive Disorder (MDD), Second Edition. Putrajaya: Ministry of Health, Malaysia; 2019

    Quick Reference: http://www.acadmed.org.my/view_file.cfm?fileid=313
    Training Manual: http://www.acadmed.org.my/view_file.cfm?fileid=315
    Patient Information Leaflet: http://www.acadmed.org.my/view_file.cfm?fileid=327

    Older version:
    Citation: Clinical Practice Guidelines: Management of Major Depressive Disorder (MDD), First Edition. Putrajaya: Ministry of Health, Malaysia; 2007
    Keywords: CPG
    Matched MeSH terms: Depressive Disorder, Major
  18. Mohd Farid Md Yusof, Shalisah Sharip, Suriati Mohamed Saini, Fairuz Nazri Abdul Rahman, Hamid Abdul Rahman, Raihanah Abdul Khalid
    MyJurnal
    A Severe encephalitis with an uncontrolled seizure may produce impairment in a variety
    of cognitive functions. The appropriate treatment for cognitive impairment postencephalitisis
    are currently unknown. We are reporting a case of depression and cognitive impairment post- encephalitis with an uncontrolled seizure. (Copied from article).
    Matched MeSH terms: Depressive Disorder
  19. Chan LF, Eu CL, Soh SY, Maniam T, Shahidii Kadir Z, Chong BTW, et al.
    J Psychiatr Pract, 2018 07;24(4):279-291.
    PMID: 30427812 DOI: 10.1097/PRA.0000000000000316
    Ketamine has shown effectiveness as a rapid-acting antidepressant with antisuicidal effects in terms of reduction of suicidal ideation in the short term. However, the evidence for long-term maintenance ketamine therapy for treatment-resistant depression (TRD) and suicidal behavior is limited. This case series (N=13) highlights the role of adjunctive serial maintenance ketamine infusions in restoring functionality in treatment-resistant unipolar and bipolar (mixed) depression with significant suicide risk and multiple comorbidities, including alcohol dependence. Two cases of TRD achieved functional remission with long-term maintenance ketamine treatment. The first case illustrates the potential synergistic interaction between ketamine and lamotrigine to achieve a sustained antidepressant response in the patient for 7 months. The second case may possibly be the longest reported case of maintenance ketamine therapy, with treatment continuing for 5 years to date. Ketamine treatment showed acute effectiveness in another 7 cases, especially in terms of reduction of suicidal ideation, albeit without significant long-term antidepressant effect. Factors that may contribute to lack of effectiveness of serial ketamine include inadequate mood stabilization in TRD in bipolar spectrum diagnoses, concomitant benzodiazepine use, complex comorbidities, and adverse effects such as significant hypertension and severe dissociation. Future systematic controlled studies are warranted to establish the efficacy and safety profile of long-term ketamine as maintenance therapy for TRD with suicidal behavior.
    Matched MeSH terms: Depressive Disorder, Major/drug therapy*; Depressive Disorder, Treatment-Resistant/drug therapy*
  20. Lee KW, Ching SM, Ramachandran V, Tusimin M, Mohd Nordin N, Chong SC, et al.
    Genes (Basel), 2019 11 30;10(12).
    PMID: 31801286 DOI: 10.3390/genes10120988
    The association of candidate genes and psychological symptoms of depression, anxiety, and stress among women with gestational diabetes mellitus (GDM) in Malaysia was determined in this study, followed by the determination of their odds of getting psychological symptoms, adjusted for socio-demographical background, maternal, and clinical characteristics. Single nucleotide polymorphisms (SNPs) recorded a significant association between SNP of EPHX2 (rs17466684) and depression symptoms (AOR = 7.854, 95% CI = 1.330-46.360) and stress symptoms (AOR = 7.664, 95% CI = 1.579-37.197). Associations were also observed between stress symptoms and SNP of OXTR (rs53576) and (AOR = 2.981, 95% CI = 1.058-8.402) and SNP of NRG1 (rs2919375) (AOR = 9.894, 95% CI = 1.159-84.427). The SNP of EPHX2 (rs17466684) gene polymorphism is associated with depression symptoms among Malaysian women with GDM. SNP of EPHX2 (rs17466684), OXTR (rs53576) and NRG1 (rs2919375) are also associated with stress symptoms.
    Matched MeSH terms: Depressive Disorder/genetics*; Depressive Disorder/physiopathology; Depressive Disorder/psychology
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