Displaying publications 1 - 20 of 25 in total

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  1. Saleh MI, Ahmad M, Darus H
    Talanta, 1990 Jul;37(7):757-9.
    PMID: 18965016
    A series of chelating reagents, 1-phenyl-3-methyl-4-(2-fluorobenzoyl)-5-pyrazolone, 1-phenyl-3-methyl-4-(3-fluorobenzoyl)-5-pyrazolone and 1-phenyl-3-methyl-4-(4-fluorobenzoyl)-5-pyrazolone, has been synthesized. The extraction of Ln(III), (Ln = La, Eu and Lu) into chloroform with these reagents at 30 +/- 1 degrees has been studied. The composition of the complexes extracted has been determined by the slope method, and the extraction constants K(ex), were measured. The presence of the fluorine atom in the reagents does not make the K(ex), values much different from those obtained with the parent pyrazolone.
    Matched MeSH terms: Fluorine
  2. Silvarajoo S, Osman UM, Kamarudin KH, Razali MH, Yusoff HM, Bhat IUH, et al.
    Data Brief, 2020 Oct;32:106299.
    PMID: 32984485 DOI: 10.1016/j.dib.2020.106299
    One-pot synthetic method was adopted to prepare three isomers 4-(ortho-fluorophenyl)thiosemi- carbazide), 4-(meta-fluorophenyl)thiosemicarbazide and 4-(para-fluorophenyl)thiosemicarbazide. The products were obtained in ethanolic solution from a reaction between ortho, meta and para derivatives of fluorophenyl isothiocyanate and hydrazine hydrate. This work presents the theoretical Molecular Electrostatic Potential (MEP) and Highest Occupied Molecular Orbital-Lowest Unoccupied Molecular Orbital (HOMO-LUMO) computational data through Gaussview 5.0.9 and Gaussian09 software. Experimental Cole-cole plot for conductivity determination was also illustrated. The present data is important to manipulate the properties of compounds according to the position of a fluorine atom.
    Matched MeSH terms: Fluorine
  3. Tooyama I, Yanagisawa D, Taguchi H, Kato T, Hirao K, Shirai N, et al.
    Ageing Res Rev, 2016 09;30:85-94.
    PMID: 26772439 DOI: 10.1016/j.arr.2015.12.008
    The formation of senile plaques followed by the deposition of amyloid-β is the earliest pathological change in Alzheimer's disease. Thus, the detection of senile plaques remains the most important early diagnostic indicator of Alzheimer's disease. Amyloid imaging is a noninvasive technique for visualizing senile plaques in the brains of Alzheimer's patients using positron emission tomography (PET) or magnetic resonance imaging (MRI). Because fluorine-19 ((19)F) displays an intense nuclear magnetic resonance signal and is almost non-existent in the body, targets are detected with a higher signal-to-noise ratio using appropriate fluorinated contrast agents. The recent introduction of high-field MRI allows us to detect amyloid depositions in the brain of living mouse using (19)F-MRI. So far, at least three probes have been reported to detect amyloid deposition in the brain of transgenic mouse models of Alzheimer's disease; (E,E)-1-fluoro-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (FSB), 1,7-bis(4'-hydroxy-3'-trifluoromethoxyphenyl)-4-methoxycarbonylethyl-1,6-heptadiene3,5-dione (FMeC1, Shiga-Y5) and 6-(3',6',9',15',18',21'-heptaoxa-23',23',23'-trifluorotricosanyloxy)-2-(4'-dimethylaminostyryl)benzoxazole (XP7, Shiga-X22). This review presents the recent advances in amyloid imaging using (19)F-MRI, including our own studies.
    Matched MeSH terms: Fluorine*
  4. Mohamad Hanafi Mohamad Rosli, Nurulhuda Amri, Norhusna Mohamad Nor
    ESTEEM Academic Journal, 2019;15(2):35-43.
    MyJurnal
    High concentration of fluoride in wastewater discharge from various industries is threatening the environment due to its hazardous effects and properties. This research work aims to develop an efficient adsorbent for fluoride removal in wastewater. Graphite oxide (GO) was impregnated
    with ZnO nanoparticles as an adsorbent, and the effect of synthesis parameters of GO-ZnO adsorbent for fluoride removal were studied (sonication temperature, synthesis time, and ratio of GO to ZnO). The surface functional groups of these synthesized adsorbents were analyzed by
    using FTIR. The synthesis parameters that contribute to the highest adsorption capacity and percentage removal are 5:1 ratio of GO-ZnO, 45 ºC of sonication temperature and 60 minutes of synthesis time, respectively. The highest value of adsorption capacity obtained from the fluoride
    removal is 55.5 mg/g. The functional groups contained in the GO-ZnO adsorbent are hydroxyl group (O-H), C=O group, aromatics group, carboxyl group (C-O), epoxy group and alkoxy group. These functional groups showed significant impact towards fluoride adsorption due to the bonding of fluoride ion to the functional groups.
    Matched MeSH terms: Fluorine; Fluorine Compounds
  5. Yanagisawa D, Ibrahim NF, Taguchi H, Morikawa S, Kato T, Hirao K, et al.
    J Neurosci Res, 2018 05;96(5):841-851.
    PMID: 29063641 DOI: 10.1002/jnr.24188
    Aggregation of tau into neurofibrillary tangles (NFTs) is characteristic of tauopathies, including Alzheimer's disease. Recent advances in tau imaging have attracted much attention because of its potential contributions to early diagnosis and monitoring of disease progress. Fluorine-19 magnetic resonance imaging (19 F-MRI) may be extremely useful for tau imaging once a high-quality probe has been formulated. In this investigation, a novel fluorine-19-labeling compound has been developed as a probe for tau imaging using 19 F-MRI. This compound is a buta-1,3-diene derivative with a polyethylene glycol side chain bearing a CF3 group and is known as Shiga-X35. Female rTg4510 mice (a mouse model of tauopathy) and wild-type mice were intravenously injected with Shiga-X35, and magnetic resonance imaging of each mouse's head was conducted in a 7.0-T horizontal-bore magnetic resonance scanner. The 19 F-MRI in rTg4510 mice showed an intense signal in the forebrain region. Analysis of the signal intensity in the forebrain region revealed a significant accumulation of fluorine-19 magnetic resonance signal in the rTg4510 mice compared with the wild-type mice. Histological analysis showed fluorescent signals of Shiga-X35 binding to the NFTs in the brain sections of rTg4510 mice. Data collected as part of this investigation indicate that 19 F-MRI using Shiga-X35 could be a promising tool to evaluate tau pathology in the brain.
    Matched MeSH terms: Fluorine*; Fluorine-19 Magnetic Resonance Imaging/methods*
  6. Hassan H, Othman MF, Zakaria ZA, Saad FFA, Abdul Razak HR
    Curr Radiopharm, 2021;14(2):131-144.
    PMID: 33115398 DOI: 10.2174/1874471013999201027215704
    BACKGROUND: Organic solvents play an indispensable role in most of the radiopharmaceutical production stages. It is almost impossible to remove them entirely in the final formulation of the product.

    OBJECTIVE: In this presented work, an analytical method by gas chromatography coupled with flame ionization detection (GC-FID) has been developed to determine organic solvents in radiopharmaceutical samples. The effect of injection holding time, temperature variation in the injection port, and the column temperature on the analysis time and resolution (R ≥ 1.5) of ethanol and acetonitrile was studied extensively.

    METHODS: The experimental conditions were optimized with the aid of further statistical analysis; thence, the proposed method was validated following the International Council for Harmonisation (ICH) Q2 (R1) guideline.

    RESULTS: The proposed analytical method surpassed the acceptance criteria including the linearity > 0.990 (correlation coefficient of R2), precision < 2%, LOD, and LOQ, accuracy > 90% for all solvents. The separation between ethanol and acetonitrile was acceptable with a resolution R > 1.5. Further statistical analysis of Oneway ANOVA revealed that the increment in injection holding time and variation of temperature at the injection port did not significantly affect the analysis time. Nevertheless, the variation in injection port temperature substantially influenced the resolution of ethanol and acetonitrile peaks (p < 0.05).

    CONCLUSION: The proposed analytical method has been successfully implemented to determine the organic solvent in the [18F]fluoro-ethyl-tyrosine ([18F]FET), [18F]fluoromisonidazole ([18F]FMISO), and [18F]fluorothymidine ([18F]FLT).

    Matched MeSH terms: Fluorine Radioisotopes/analysis; Fluorine Radioisotopes/chemistry*
  7. Hassan H, Abu Bakar S, Halim KN, Idris J, Ahmad Saad FF, Nordin AJ
    J Labelled Comp Radiopharm, 2015 Sep-Oct;58(11-12):458-9.
    PMID: 26395258 DOI: 10.1002/jlcr.3347
    (18)F-Fluoromethylcholine ((18)F-FCH) has been suggested as one of the reputable imaging tracers for diagnosis of prostate tumour in PET/CT examination. Nevertheless, it has never been synthesised in Malaysia. We acknowledged the major problem with (18)F-FCH is due to its relatively low radiochemical yield at the end of synthesis (EOS). Therefore, this technical note presents improved (18)F-FCH radiochemical yields after carrying out optimisation on azeotropic drying of non-carrier-added (18)F-Fluorine.
    Matched MeSH terms: Fluorine
  8. Lazim ZM, Hadibarata T
    Braz J Microbiol, 2016 Jul-Sep;47(3):610-6.
    PMID: 27287336 DOI: 10.1016/j.bjm.2016.04.015
    This study aimed to investigate the impact of nonionic surfactants on the efficacy of fluorine degradation by Polyporus sp. S133 in a liquid culture. Fluorene was observed to be degraded in its entirety by Polyporus sp. S133 subsequent to a 23-day incubation period. The fastest cell growth rate was observed in the initial 7 days in the culture that was supplemented with Tween 80. The degradation process was primarily modulated by the activity of two ligninolytic enzymes, laccase and MnP. The highest laccase activity was stimulated by the addition of Tween 80 (2443U/L) followed by mixed surfactant (1766U/L) and Brij 35 (1655U/L). UV-vis spectroscopy, TLC analysis and mass spectrum analysis of samples subsequent to the degradation process in the culture medium confirmed the biotransformation of fluorene. Two metabolites, 9-fluorenol (λmax 270, tR 8.0min and m/z 254) and protocatechuic acid (λmax 260, tR 11.3min and m/z 370), were identified in the treated medium.
    Matched MeSH terms: Fluorine
  9. Lee HB, Ginting RT, Tan ST, Tan CH, Alshanableh A, Oleiwi HF, et al.
    Sci Rep, 2016 09 02;6:32645.
    PMID: 27587295 DOI: 10.1038/srep32645
    Anion passivation effect on metal-oxide nano-architecture offers a highly controllable platform for improving charge selectivity and extraction, with direct relevance to their implementation in hybrid solar cells. In current work, we demonstrated the incorporation of fluorine (F) as an anion dopant to address the defect-rich nature of ZnO nanorods (ZNR) and improve the feasibility of its role as electron acceptor. The detailed morphology evolution and defect engineering on ZNR were studied as a function of F-doping concentration (x). Specifically, the rod-shaped arrays of ZnO were transformed into taper-shaped arrays at high x. A hypsochromic shift was observed in optical energy band gap due to the Burstein-Moss effect. A substantial suppression on intrinsic defects in ZnO lattice directly epitomized the novel role of fluorine as an oxygen defect quencher. The results show that 10-FZNR/P3HT device exhibited two-fold higher power conversion efficiency than the pristine ZNR/P3HT device, primarily due to the reduced Schottky defects and charge transfer barrier. Essentially, the reported findings yielded insights on the functions of fluorine on (i) surface -OH passivation, (ii) oxygen vacancies (Vo) occupation and (iii) lattice oxygen substitution, thereby enhancing the photo-physical processes, carrier mobility and concentration of FZNR based device.
    Matched MeSH terms: Fluorine
  10. Chong SW, Lai CW, Abd Hamid SB
    Materials (Basel), 2016 Jan 25;9(2).
    PMID: 28787869 DOI: 10.3390/ma9020069
    A controllable electrochemical synthesis to convert reduced graphene oxide (rGO) from graphite flakes was introduced and investigated in detail. Electrochemical reduction was used to prepare rGO because of its cost effectiveness, environmental friendliness, and ability to produce rGO thin films in industrial scale. This study aimed to determine the optimum applied potential for the electrochemical reduction. An applied voltage of 15 V successfully formed a uniformly coated rGO thin film, which significantly promoted effective electron transfer within dye-sensitized solar cells (DSSCs). Thus, DSSC performance improved. However, rGO thin films formed in voltages below or exceeding 15 V resulted in poor DSSC performance. This behavior was due to poor electron transfer within the rGO thin films caused by poor uniformity. These results revealed that DSSC constructed using 15 V rGO thin film exhibited high efficiency (η = 1.5211%) attributed to its higher surface uniformity than other samples. The addition of natural lemon juice (pH ~ 2.3) to the electrolyte accelerated the deposition and strengthened the adhesion of rGO thin film onto fluorine-doped tin oxide (FTO) glasses.
    Matched MeSH terms: Fluorine
  11. Wardell JL, Jotani MM, Tiekink ERT
    Acta Crystallogr E Crystallogr Commun, 2019 Aug 01;75(Pt 8):1162-1168.
    PMID: 31417785 DOI: 10.1107/S2056989019009654
    The asymmetric unit of the centrosymmetric title salt solvate, 2C17H17F6N2O+· C4H4O42-·CH3CH2OH, (systematic name: 2-{[2,8-bis-(tri-fluoro-meth-yl)quinolin-4-yl](hy-droxy)meth-yl}piperidin-1-ium butane-dioate ethanol monosolvate) comprises two independent cations, with almost superimposable conformations and each approximating the shape of the letter L, a butane-dioate dianion with an all-trans conformation and an ethanol solvent mol-ecule. In the crystal, supra-molecular chains along the a-axis direction are sustained by charge-assisted hy-droxy-O-H⋯O(carboxyl-ate) and ammonium-N-H⋯O(carboxyl-ate) hydrogen bonds. These are connected into a layer via C-F⋯π(pyrid-yl) contacts and π-π stacking inter-actions between quinolinyl-C6 and -NC5 rings of the independent cations of the asymmetric unit [inter-centroid separations = 3.6784 (17) and 3.6866 (17) Å]. Layers stack along the c-axis direction with no directional inter-actions between them. The analysis of the calculated Hirshfeld surface reveals the significance of the fluorine atoms in surface contacts. Thus, by far the greatest contribution to the surface contacts, i.e. 41.2%, are of the type F⋯H/H⋯F and many of these occur in the inter-layer region. However, these contacts occur at separations beyond the sum of the van der Waals radii for these atoms. It is noted that H⋯H contacts contribute 29.8% to the overall surface, with smaller contributions from O⋯H/H⋯O (14.0%) and F⋯F (5.7%) contacts.
    Matched MeSH terms: Fluorine
  12. Abu Bakar Mohamad, Wan Ramli Wan Daud, Amir Kadhum, Fathi Messaud, Mohd. Ambar Yarmo
    Chemical structure of treated and untreated Aciplex membrane has been studied by X-ray Photoelectron Spectroscopy (XPS). Survey spectra showed that both membrane surfaces consist of Fluorine, Carbon, Oxygen, Sulphur and trace of Titanium. Binding energies for the elements are (C1s at 290.6 eV, F1s at 687.5 eV, O1s at 531.3 eV, S2P at 168.1 eV and Ti2P at 454.4 eV). Analysis of narrow scan XPS-spectra of each element demonstrate the presence of (-CF, -CF2, CF3, C-O-C and SO-3) groups, which are in agreement with the structural formula as disclosed by the manufacturer. There is no significant change in chemical states of untreated and treated membrane, which reflect its stability to treatment conditions.
    Struktur kimia Aciplex membran yang sudah dibersihkan dan yang belum dibersihkan telah dikaji menggunakan Spektroskopi Fotoelektron Sinaran-X (XPS). Spektra yang telah ditinjau menunjukkan bahawa kedua-dua permukaan membran mengandungi Florin, Karbon, Oksigen, Sulfur dan sedikit Titanium. Tenaga ikatan bagi unsur-unsur tersebut adalah (C1s pada 290.6 eV, F1s pada 687.5 eV. O1s pada 531.3 eV, S2P pada 168.2 eV dan Ti2P pada 454.4 eV). Analisis imbasan kecil spektra-xps bagi setiap unsur menunjukkan kehadiran kilmpulan (-CF, - CF2, CF3, C-O-C dan SO-3) yang bertepatan dengan formula struktur dari pihak pembekal. Tiada terdapat perubahan nyata berhubung dengan keadaan kimia membran yang sudah dibersihkan dan yang belum dibersihkan yang menggambarkan kestabilannya terhadap keadaan pembersihan.
    Matched MeSH terms: Fluorine
  13. Noor Kamalia Abd Hamed, Noor Sakinah Khalid, Fatin Izyani Mohd Fazli, Muhammad Luqman Mohd Napi, Nafarizal Nayan, Mohd Khairul Ahmad
    Sains Malaysiana, 2016;45:1669-1673.
    Titanium dioxide (TiO2
    ) with various morphologies has been successfully synthesized by a simple hydrothermal method
    at 150o
    C for 10 h using titanium butoxide (TBOT) as a precursor, deionized (DI) water and hydrochloric acid (HCl) on
    a fluorine-doped tin oxide (FTO) substrate. The influences of HCl volume on structural and morphological properties
    of TiO2
    have been studied using x-ray diffraction (XRD) and field emission scanning electron microscopy (FESEM),
    respectively. The result showed that several morphologies such as microsphere, microrods, nanorods and nanoflowers
    were obtained by varying the volume of hydrochloric acid. The crystallinity of titanium dioxide enhanced with the
    increasing of hydrochloric acid volume.
    Matched MeSH terms: Fluorine
  14. Lim YH, Oo CW, Koh RY, Voon GL, Yew MY, Yam MF, et al.
    Drug Dev Res, 2020 Jul 28.
    PMID: 32720715 DOI: 10.1002/ddr.21715
    In recent years, chalcones and their derivatives have become the focus of global scientists due to increasing evidence reported towards their potency in antitumor and anti-cancer. Here, the chalcones designed and synthesized in our present study were derived from the derivatives of naphthaldehyde and acetophenone. Both these precursors have been reported in demonstrating a certain degree of anticancer property. Also, the substituents on these precursors such as hydroxyl, methoxy, prenyl, and chloro were shown able to enhance the anticancer efficiency. Hence, it is the interest of the current study to investigate the anticancer potential of the hybrid molecules (chalcones) consisting of these precursors with different alkoxy substituents and with or without the fluorine moiety. Two series of chalcone derivatives were designed, synthesized, and characterized using the elemental analysis, IR, 1 H and 13 C NMR spectroscopy, subsequently evaluated for their anti-cancer activity. Interestingly, the results showed that the fluorinated chalcones 11-15 exhibited stronger cytotoxic activity towards the breast cancer cell lines (4T1) compared to non-fluorinated chalcone derivatives. Remarkably, the selectivity index obtained for these fluorinated chalcones derivatives against the breast cancer 4T1 cell line was higher than those exhibited by cisplatin, which is one of the most frequently deployed chemotherapy agents in current medical practice. These findings could provide an insight towards the potential of fluorinated chalcones being developed as an anti-cancer agent with moderate activity towards breast cancer cell and low inhibition of fibroblast cell at a concentration of 100 μM.
    Matched MeSH terms: Fluorine
  15. Ng ZC, Roslan RA, Lau WJ, Gürsoy M, Karaman M, Jullok N, et al.
    Polymers (Basel), 2020 Aug 21;12(9).
    PMID: 32825561 DOI: 10.3390/polym12091883
    The non-selective property of conventional polyurethane (PU) foam tends to lower its oil absorption efficiency. To address this issue, we modified the surface properties of PU foam using a rapid solvent-free surface functionalization approach based on the chemical vapor deposition (CVD) method to establish an extremely thin yet uniform coating layer to improve foam performance. The PU foam was respectively functionalized using different monomers, i.e., perfluorodecyl acrylate (PFDA), 2,2,3,4,4,4-hexafluorobutyl acrylate (HFBA), and hexamethyldisiloxane (HMDSO), and the effect of deposition times (1, 5 and 10 min) on the properties of foam was investigated. The results showed that all the modified foams demonstrated a much higher water contact angle (i.e., greater hydrophobicity) and greater absorption capacities compared to the control PU foam. This is due to the presence of specific functional groups, e.g., fluorine (F) and silane (Si) in the modified PU foams. Of all, the PU/PHFBAi foam exhibited the highest absorption capacities, recording 66.68, 58.15, 53.70, and 58.38 g/g for chloroform, acetone, cyclohexane, and edible oil, respectively. These values were 39.19-119.31% higher than that of control foam. The promising performance of the PU/PHFBAi foam is due to the improved surface hydrophobicity attributed to the original perfluoroalkyl moieties of the HFBA monomer. The PU/PHFBAi foam also demonstrated a much more stable absorption performance compared to the control foam when both samples were reused for up to 10 cycles. This clearly indicates the positive impact of the proposed functionalization method in improving PU properties for oil absorption processes.
    Matched MeSH terms: Fluorine
  16. Hassan H, Bakar SA, Halim KN, Idris J, Saad FF, Nordin AJ
    Curr Radiopharm, 2016;9(2):121-7.
    PMID: 26239237
    BACKGROUND AND OBJECTIVE: 18F-Fluorocholine has been suggested as one of the reputable imaging tracers for diagnosis of prostate tumour in Positron Emission Tomography / Computed Tomography (PET/CT) modality. Nevertheless, it has never been synthesised in Malaysia. We acknowledged that the major problem with 18F-Fluorocholine is due to its relatively low radiochemical yield at the end of synthesis (EOS). Therefore, this article presents improved 18FFluorocholine radiochemical yields after carrying out optimisation on azeotropic drying of 18F-Fluorine.

    METHODS: In the previous study, the azeotropic drying of non-carrier-added (n.c.a) 18F-Fluorine in the reactor was conducted at atmospheric pressure (0 atm) and shorter duration time. In this study, however, the azeotropic drying of non-carried-added (n.c.a) 18FFluorine was made at a high vacuum pressure (- 0.65 to - 0.85 bar) with an additional time of 30 seconds. At the end of the synthesis, the mean radiochemical yield was statistically compared between the two azeotropic drying conditions so as to observe whether the improvement made was significant to the radiochemical yield.

    RESULTS: From the paired sample t-test analysis, the improvement done to the azeotropic drying of non-carrier-added (n.c.a) 18F-Fluorine was statistically significant (p < 0.05). With the improvement made, the 18F-Fluorcholine radiochemical yield was found to have increase by one fold.

    CONCLUSION: Improved 18F-Fluorocholine radiochemical yields were obtained after the improvement had been done to the azeotropic drying of non-carrier-added (n.c.a) 18F-Fluorine. It was also observed that improvement made to the azeotropic drying of non-carrier-added (n.c.a) 18F-Fluorine did not affect the 18F-Fluorocholine quality control analysis.

    Matched MeSH terms: Fluorine Radioisotopes/chemistry*
  17. Usmani S, Rasheed R, Al Kandari F
    J Nucl Med Technol, 2020 Jun;48(2):181-183.
    PMID: 32111663 DOI: 10.2967/jnmt.119.235986
    Textitis is a new term used to refer to the degenerative-strain osteoarthritis that comes from excessive use of a smart phone. 18F-NaF is increasingly used in diagnosing skeletal pain that is not identified on radiographs. We report a case of a 26-y-old woman with left breast cancer referred for 18F-NaF PET/CT, who was complaining of right thumb and wrist pain. Findings were negative for bone secondaries. Dedicated hands views were acquired on a positron emission mammography scanner and showed focal uptake at the first carpometacarpal and second metacarpophalangeal joints. On the basis of the strong history, the findings were likely due to active arthritic changes caused by repetitive strain injury from excessive text messaging.
    Matched MeSH terms: Fluorine Radioisotopes*
  18. Barakat A, Al-Majid AM, Soliman SM, Lotfy G, Ghabbour HA, Fun HK, et al.
    Molecules, 2015;20(11):20642-58.
    PMID: 26610441 DOI: 10.3390/molecules201119710
    The synthesis of the new diethyl ammonium salt of diethylammonium(E)-5-(1,5-bis(4-fluorophenyl)-3-oxopent-4-en-1-yl)-1,3-diethyl-4,6-dioxo-2-thioxohexaydropyrimidin-5-ide 3 via a regioselective Michael addition of N,N-diethylthiobarbituric acid 1 to dienone 2 is described. In 3, the carboanion of the thiobarbituric moiety is stabilized by the strong intramolecular electron delocalization with the adjacent carbonyl groups and so the reaction proceeds without any cyclization. The molecular structure investigations of 3 were determined by single-crystal X-ray diffraction as well as DFT computations. The theoretically calculated (DFT/B3LYP) geometry agrees well with the crystallographic data. The effect of fluorine replacement by chlorine atoms on the molecular structure aspects were investigated using DFT methods. Calculated electronic spectra showed a bathochromic shift of the π-π* transition when fluorine is replaced by chlorine. Charge decomposition analyses were performed to study possible interaction between the different fragments in the studied systems. Molecular docking simulations examining the inhibitory nature of the compound show an anti-diabetic activity with Pa (probability of activity) value of 0.229.
    Matched MeSH terms: Fluorine
  19. Ghazali SK, Adrus N, Majid RA, Ali F, Jamaluddin J
    Polymers (Basel), 2021 Feb 04;13(4).
    PMID: 33557118 DOI: 10.3390/polym13040487
    The elimination of mercury, low energy consumption, and low heat make the ultraviolet light-emitting diode (UV-LED) system emerge as a promising alternative to conventional UV-mercury radiation coating. Hence, a series of hydrophobic coatings based on urethane acrylate oligomer and fluorinated monomer via UV-LED photopolymerisation was designed in this paper. The presence of fluorine component at 1160 cm-1, 1235 cm-1, and 1296 cm-1 was confirmed by Fourier Transform Infra-Red spectroscopy. A considerably high degree C=C conversion (96-98%) and gel fraction (95-93%) verified the application of UV-LED as a new technique in radiation coating. It is well-accepted that fluorinated monomer can change the surface wettability as the water contact angle of the coating evolved from 88.4° to 121.2°, which, in turn, reduced its surface free energy by 70.5%. Hence, the hydrophobicity of the coating was governed by the migration of the fluorine component to the coating surface as validated by scanning electron and atomic force microscopies. However, above 4 phr of fluorinated monomer, the transparency of the cured coating examined by UV-visible spectroscopy experienced approximately a 16% reduction. In summary, the utilisation of UV-LED was a great initiative to develop green aspect in photopolymerisation, particularly in coating technology.
    Matched MeSH terms: Fluorine
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