Displaying publications 1 - 20 of 69 in total

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  1. Fulltext Growing teratoma syndrome: a rare case report and review of the literature
    Kampan N, Irianta T, Djuana A, Pei Shan L, Hashim Omar M, Hatta Mohd Dali AZ
    Case Rep Obstet Gynecol, 2012;2012:134032.
    PMID: 22645693 DOI: 10.1155/2012/134032
    Growing teratoma syndrome is rare and usually it occurs in the younger aged group. The use of chemotherapy following initial surgical resection will yield the diagnosis following tumour enlargement. Complete resection is usually curative and renders better prognosis.
    Matched MeSH terms: Hypertrophy
  2. Fulltext Surgical Interventions for Inferior Turbinate Hypertrophy: A Comprehensive Review of Current Techniques and Technologies
    Abdullah B, Singh S
    Int J Environ Res Public Health, 2021 03 26;18(7).
    PMID: 33810309 DOI: 10.3390/ijerph18073441
    Surgical treatment of the inferior turbinates is required for hypertrophic inferior turbinates refractory to medical treatments. The main goal of surgical reduction of the inferior turbinate is to relieve the obstruction while preserving the function of the turbinate. There have been a variety of surgical techniques described and performed over the years. Irrespective of the techniques and technologies employed, the surgical techniques are classified into two types, the mucosal-sparing and non-mucosal-sparing, based on the preservation of the medial mucosa of the inferior turbinates. Although effective in relieving nasal block, the non-mucosal-sparing techniques have been associated with postoperative complications such as excessive bleeding, crusting, pain, and prolonged recovery period. These complications are avoided in the mucosal-sparing approach, rendering it the preferred option. Although widely performed, there is significant confusion and detachment between current practices and their basic objectives. This conflict may be explained by misperception over the myriad of available surgical techniques and misconception of the rationale in performing the turbinate reduction. A comprehensive review of each surgical intervention is crucial to better define each procedure and improve understanding of the principle and mechanism involved.
    Matched MeSH terms: Hypertrophy/surgery
  3. Fulltext Microdebrider-assisted inferior turbinoplasty versus other surgical techniques
    Kanesan N, Norhayati MN, Hamid SSA, Abdullah B
    Acta Otorhinolaryngol Ital, 2022 Oct;42(5):415-426.
    PMID: 36541379 DOI: 10.14639/0392-100X-N1896
    Matched MeSH terms: Hypertrophy/surgery
  4. Kasabach-Merritt syndrome and Down's syndrome
    Ram SP
    J R Soc Med, 1997 Mar;90(3):159-60.
    PMID: 9135617
    Matched MeSH terms: Hypertrophy/congenital
  5. Fulltext Lingual tonsillitis post tonsillectomy: a rare cause of odynophagia
    Irfan Mohamad, Fard, Kambiz Karimian, Hazama Mohama
    Archives of Orofacial Sciences, 2010;5(1):29-30.
    MyJurnal
    Lingual tonsil is a part of Waldeyer’s ring. It consists of lymphoid follicles and subject to proliferation and hypertrophy. Palatine tonsillitis, by far is the commonest cause of odynophagia originating from oropharyngeal region. Lingual tonsillitis is a rare occurrence. We reported a patient who presented with severe odynophagia after two months of palatine tonsillectomy. Examination revealed the lingual tonsils were inflamed and covered with exudates.
    Matched MeSH terms: Hypertrophy
  6. Fulltext MRI findings of orbicularis oculi hypertrophy due to heavy resistance training on the inferior orbital rim
    Hasyma Abu Hassan, Norlisah Mohd Ramli, Fong, Kenneth C.S., Goh, Khean-Jin
    Neurology Asia, 2013;18(4):427-429.
    MyJurnal
    Increase in cross-sectional muscle area of major muscle groups associated by heavy resistance training has been well documented. However, there has been no published article of changes in the inferior orbicularis oculi muscle when heavy resistance training is applied. We present a case of inferior orbicularis hypertrophy detected on MRI in a gentleman who practised heavy resistance training using his lower eyelids.
    Matched MeSH terms: Hypertrophy
  7. Fulltext Native T1 and T2 provide distinctive signatures in hypertrophic cardiac conditions - Comparison of uremic, hypertensive and hypertrophic cardiomyopathy
    Arcari L, Hinojar R, Engel J, Freiwald T, Platschek S, Zainal H, et al.
    Int J Cardiol, 2020 05 01;306:102-108.
    PMID: 32169347 DOI: 10.1016/j.ijcard.2020.03.002
    AIMS: Profound left ventricular (LV) hypertrophy with diastolic dysfunction and heart failure is the cardinal manifestation of heart remodelling in chronic kidney disease (CKD). Previous studies related increased T1 mapping values in CKD with diffuse fibrosis. Native T1 is a non-specific readout that may also relate to increased intramyocardial fluid. We examined concomitant T1 and T2 mapping signatures and undertook comparisons with other hypertrophic conditions.

    METHODS: In this prospective multicentre study, consecutive CKD patients (n = 154) undergoing routine clinical cardiac magnetic resonance (CMR) imaging were compared with patients with hypertensive (HTN, n = 163) and hypertrophic cardiomyopathy (HCM, n = 158), and normotensive controls (n = 133).

    RESULTS: Native T1 was significantly higher in all patient groups, whereas native T2 in CKD only (p 

    Matched MeSH terms: Hypertrophy, Left Ventricular/pathology
  8. Fulltext Interaction between nitric oxide and renal α1-adrenoreceptors mediated vasoconstriction in rats with left ventricular hypertrophyin Wistar Kyoto rats
    Ahmad A, Sattar MA, Azam M, Khan SA, Bhatt O, Johns EJ
    PLoS One, 2018;13(2):e0189386.
    PMID: 29447158 DOI: 10.1371/journal.pone.0189386
    Left ventricular hypertrophy (LVH) is associated with decreased responsiveness of renal α1-adrenoreceptors subtypes to adrenergic agonists. Nitric oxide donors are known to have antihypertrophic effects however their impact on responsiveness of renal α1-adrenoreceptors subtypes is unknown. This study investigated the impact of nitric oxide (NO) and its potential interaction with the responsiveness of renal α1-adrenoreceptors subtypes to adrenergic stimulation in rats with left ventricular hypertrophy (LVH). This study also explored the impact of NO donor on CSE expression in normal and LVH kidney. LVH was induced using isoprenaline and caffeine in drinking water for 2 weeks while NO donor (L-arginine, 1.25g/Lin drinking water) was given for 5 weeks. Intrarenal noradrenaline, phenylephrine and methoxamine responses were determined in the absence and presence of selective α1-adrenoceptor antagonists, 5- methylurapidil (5-MeU), chloroethylclonidine (CeC) and BMY 7378. Renal cortical endothelial nitric oxide synthase mRNA was upregulated 7 fold while that of cystathione γ lyase was unaltered in the NO treated LVH rats (LVH-NO) group compared to LVH group. The responsiveness of renal α1A, α1B and α1D-adrenoceptors in the low dose and high dose phases of 5-MeU, CEC and BMY7378 to adrenergic agonists was increased along with cGMP in the kidney of LVH-NO group. These findings suggest that exogenous NO precursor up-regulated the renal eNOS/NO/cGMP pathway in LVH rats and resulted in augmented α1A, α1B and α1D adrenoreceptors responsiveness to the adrenergic agonists. There is a positive interaction between H2S and NO production in normal animals but this interaction appears absent in LVH animals.
    Matched MeSH terms: Hypertrophy, Left Ventricular/physiopathology*
  9. Fulltext Deterioration of left ventricular systolic function in extended Pacing to Avoid Cardiac Enlargement (PACE) trial: the predictive value of early systolic dyssynchrony
    Fang F, Luo XX, Zhang Q, Azlan H, Razali O, Ma Z, et al.
    Europace, 2015 Oct;17 Suppl 2:ii47-53.
    PMID: 26842115 DOI: 10.1093/europace/euv130
    Biventricular (BiV) pacing was superior to right ventricular apical (RVA) pacing at extended follow-up in the Pacing to Avoid Cardiac Enlargement (PACE) trial. Early pacing-induced systolic dyssynchrony (DYS) might be related to mid-term result. However, it remains unknown whether early pacing-induced DYS can predict long-term reduction of left ventricular (LV) systolic function.
    Matched MeSH terms: Hypertrophy, Left Ventricular/diagnosis; Hypertrophy, Left Ventricular/etiology*; Hypertrophy, Left Ventricular/prevention & control*
  10. Fulltext Swiftlase assisted CO2 laser ablation in the treatment of nasal obstruction due to hypertrophy of the inferior turbinates
    Sani A, Primuharsa P
    Med J Malaysia, 2001 Jun;56(2):174-9.
    PMID: 11771077
    Hypertrophy of the inferior turbinates are the major cause of nasal obstruction. CO2 lasers have been used to reduce the size of the inferior turbinates over the last 20 years. However, the many techniques of delivery of the laser show that there is no one standard method reducing the size of the turbinates. We now describe how the laser can be applied directly to the turbinates using a handpiece with a special nasal tip, thus overcoming the disadvantages delivery via arthroscopic devices, microscopes and fibers. This technique is further enhanced by coupling it with Swiftlase which swirls the focused beam in a 3 mm spot thus ablating tissue more quickly. This procedure is done under local anaesthesia. The ablation of the anterior third of the inferior turbinates effectively overcomes nasal obstruction. This new method was compared to the more traditional submucus diathermy. 22 patients were subjected to laser treatment whilst 20 patients were subjected to diathermy. The outcome was evaluated subjectively by the patients themselves at 2 weeks, 3 months and 6 months. At the end of the study, the laser group reported a more significantly improved nasal airway (91% against 75%) and decreased rhinorrhea (72.7% against 35%) when compared to the diathermy group.
    Matched MeSH terms: Hypertrophy/complications*; Hypertrophy/pathology; Hypertrophy/surgery*
  11. Left ventricular hypertrophy and its relation to the cardiac kinin-forming system in hypertensive and diabetic rats
    Sharma JN, Uma K, Yusof AP
    Int J Cardiol, 1998 Feb 28;63(3):229-35.
    PMID: 9578349 DOI: 10.1016/s0167-5273(97)00329-x
    We investigated the cardiac tissue kallikrein and kininogen levels, left ventricular wall thickness and mean arterial blood pressure of Wistar Kyoto and spontaneously hypertensive rats with and without streptozotocin-induced diabetes. The mean arterial blood pressure was highly elevated (P<0.001) in Wistar Kyoto diabetic and spontaneously hypertensive diabetic rats as compared with their respective controls. The cardiac tissue kallikrein and kininogen levels were reduced significantly (P<0.001) in diabetic Wistar Kyoto, spontaneously hypertensive and diabetic spontaneously hypertensive compared with Wistar Kyoto control rats. In addition, the left ventricular thickness was found to be increased (P<0.001) in diabetic Wistar Kyoto and spontaneously hypertensive rats in the presence and in the absence of diabetes. Our results indicate that reduced activity of the kinin-forming system may be responsible for inducing left ventricular hypertrophy in the presence of raised mean arterial blood pressure in diabetic and hypertensive rats. Thus, the kinin-forming components might have a protective role against the development of left ventricular hypertrophy. The possible significance of these findings is discussed.
    Matched MeSH terms: Hypertrophy, Left Ventricular/complications; Hypertrophy, Left Ventricular/physiopathology*
  12. Fulltext Rare Copy Number Variants Identified Suggest the Regulating Pathways in Hypertension-Related Left Ventricular Hypertrophy
    Boon-Peng H, Mat Jusoh JA, Marshall CR, Majid F, Danuri N, Basir F, et al.
    PLoS One, 2016;11(3):e0148755.
    PMID: 26930585 DOI: 10.1371/journal.pone.0148755
    Left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular morbidity and mortality, and a powerful predictor of adverse cardiovascular outcomes in the hypertensive patients. It has complex multifactorial and polygenic basis for its pathogenesis. We hypothesized that rare copy number variants (CNVs) contribute to the LVH pathogenesis in hypertensive patients. Copy number variants (CNV) were identified in 258 hypertensive patients, 95 of whom had LVH, after genotyping with a high resolution SNP array. Following stringent filtering criteria, we identified 208 rare, or private CNVs that were only present in our patients with hypertension related LVH. Preliminary findings from Gene Ontology and pathway analysis of this study confirmed the involvement of the genes known to be functionally involved in cardiac development and phenotypes, in line with previously reported transcriptomic studies. Network enrichment analyses suggested that the gene-set was, directly or indirectly, involved in the transcription factors regulating the "foetal cardiac gene programme" which triggered the hypertrophic cascade, confirming previous reports. These findings suggest that multiple, individually rare copy number variants altering genes may contribute to the pathogenesis of hypertension-related LVH. In summary, we have provided further supporting evidence that rare CNV could potentially impact this common and complex disease susceptibility with lower heritability.
    Matched MeSH terms: Hypertrophy, Left Ventricular/etiology; Hypertrophy, Left Ventricular/genetics*
  13. Fulltext Femoral Shaft Cortical Pathology associated with longterm Alendronate Therapy: A New Classification
    Kwan M, Chan C, Ng W, Merican A, Chung W, Chan S
    Malays Orthop J, 2013 Jul;7(2):12-7.
    PMID: 25722819 MyJurnal DOI: 10.5704/MOJ.1307.008
    There are reported cases of cortical reaction over the tension side of the normal femoral shafts in patients on long term treatment with alendronate, leading to subsequent femoral shaft fractures. We performed a retrospective review of patients with low-energy femoral shaft fracture on alendronate, admitted to our institution during the period 2004 to May 2009. The presence of radiological changes of cortical hypertrophy with or without Looser's zone over the tension side of the femoral bone (normal limb) was determined and correlated with clinical symptoms. Thirteen patients were identified. Average duration of alendronate use was 6.5 ± 3.3 years (ranges, two to 10 years). These radiological changes were noted in four patients. Average duration of alendronate usage in these four patients was 6.5 ± 2.4 years (ranges, 5 to10 years). Prodromal thigh pain was present in a patient, who had cortical hypertrophy with the presence of a Looser's zone traversing the cortex on the femoral shaft. One patient had Looser's zone limited at the lateral hypertrophied cortex without prodromal pain. The interobserver kappa coefficient was 0.96. A femoral radiograph should be performed in all patients who are on long-term alendronate therapy who present with thigh pain. We propose a new grading system based on our observation of the radiological features in these four cases. This new grading of the radiological spectrum of femoral shaft cortical pathology has the potential to stratify the risk of low energy femoral fracture for patients treated with long-term alendronate therapy.
    Matched MeSH terms: Hypertrophy
  14. Fulltext Bilateral neonatal breast abscess in a well-appearing neonate
    Muhammad Yusoff Mohd Ramdzan, Jamil Aiman Mohd Baharuddin, Nordiyana Azmi, Noraida Ramli, Nor Rosidah Ibrahim, Rostenberghe, Hans Van
    Malaysian Journal of Paediatrics and Child Health, 2019;25(1):27-29.
    MyJurnal
    Neonatal mastitis and abscess are rare and most often unilateral. Neonatal breast massage for physiological breast hypertrophy is suspected to be a predisposing factor in the case reported here: a 14-day-old neonate with bilateral neonatal breast abscess, treated effectively with intravenous cloxacillin and surgical aspiration.
    Matched MeSH terms: Hypertrophy
  15. The cause of pyloric stenosis of infancy: A hyperacidity pathogenesis
    Rogers IM
    Med Hypotheses, 2020 Aug;141:108116.
    PMID: 26654484 DOI: 10.1016/j.mehy.2015.11.023
    The cause of pyloric stenosis of infancy (PS) is at present unknown. A theory of causation is proposed which is consistent with all the known clinical features of this condition. It is based on the knowledge that PS babies are hypersecretors of acid which pre-dates the development of PS and is an inherited constitutional feature. This acidity will become temporarily and dangerously high due to an insensitivity of the negative feed-back between gastrin and gastric acidy within the first few weeks of life. Normal babies who have inherited normal acidity will also experience peak acid secretions at that time but will be much less acid than babies destined to develop PS. Acid entering the duodenum causes contraction of the pyloric sphincter. Hyperacidity will naturally lead to repeated pyloric sphincter contractions and sphincter hypertrophy. Inappropriate repeated feeding of the vomiting PS baby by a first-time overanxious mother to her ever hungry baby, by provoking feed related sphincter contraction is considered to play a significant part in pathogenesis. Should the baby with PS survive beyond the age of around 6weeks, the matured negative feed-back between gastrin and acid will ensure that dangerous hyperacidity is kept in check. This coupled with the natural pyloric canal widening with age, will lead then to an long lasting cure. This theory explains satisfactorily all the known and hitherto unexplained features of this condition.
    Matched MeSH terms: Hypertrophy
  16. Fulltext Revisiting asthma phenotype in children
    Fahisham Taib
    Malaysian Journal of Paediatrics and Child Health, 2011;17(1):0-0.
    MyJurnal
    Asthma is considered as heterogeneous multidimensional disorder due to variable phenotypic presentation. Phenotype is defined as a cluster of either clinical or pathologic features, which tends to be associated with the understanding the mechanisms of the disease. Asthma is typically characterized by airway inflammation, variable airway obstruction, bronchial hyper-reactivity, smooth muscle hypertrophy and apparent reversible airflow obstruction by bronchodilators. ‘Asthma syndrome’ is a term to describe complex pathophysiology of the condition which is not exclusive to allergen triggered episodes. Diagnosing childhood asthma is difficult, due to the similarity of symptoms and overlapping with other wheezing conditions. The precise mechanism for asthma exacerbation, for each individual phenotype is not fully understood. However, it is influenced by genetic interaction with variety of external environmental stimuli. The current understanding on asthma phenotypes were interpreted based on age of onset, associated triggers, clinical aspects, physiologic parameters and type of inflammation (Table 1). Due to the illdefined of the current phenotypic definition and disagreement among the respirologists, it is becoming a challenge to label specific phenotype with certainty. Accurate definition of each phenotype should therefore be helpful to provide better understanding of different mechanistic pathways and focusing on targeted therapy for individual phenotype. (Copied from article).
    Matched MeSH terms: Hypertrophy
  17. Fulltext Juvenile Breast Hypertrophy: A Successful Breast Reduction of 14.9% Body Weight without Recurrence in a 5-Year Follow-Up
    Hisham A, Abd Latib M, Basiron N
    Case Rep Surg, 2017;2017:3491012.
    PMID: 28255494 DOI: 10.1155/2017/3491012
    Juvenile hypertrophy of the breast (JHB) is a rare and relentless disease affecting women in the peripubertal period. We present a 13-year-old girl with massive bilateral JHB, successfully treated with a breast reduction and free nipple graft technique. A total of 7300 grams of breast tissue had been removed, accounting for 14.9% of the patient's total body weight. Prophylactic hormonal therapy was not commenced. During the 5-year follow-up period, there was no recurrence and the patient remains satisfied with the aesthetic outcome. A recent meta-analysis study indicates that subcutaneous mastectomy is associated with reduced risk of recurrence, but it is more deforming and the aesthetic result is inferior to a reduction mammaplasty. In patients treated with the latter technique, some evidence exists suggesting that the use of a free nipple graft is associated with a less frequent risk of recurrence than a pedicle technique. This present case is unique as it demonstrates the clinical course of this patient at a considerably longer follow-up period than most reported studies. We adhered to the limited available evidence and highlight the long-term reliability of breast reduction with free nipple grafting as the first line surgical option in JHB, eliminating the need for repeated surgeries.
    Matched MeSH terms: Hypertrophy
  18. Fulltext The expert says........ current concept in gingival overgrowth
    Ahmad Sharifuddin Mohd Asari
    Malaysian Dental Journal, 2007;28(2):107-111.
    MyJurnal
    Gingival overgrowth (gingival hyperplasia, gingival fibromatosis) can be caused by underlying factors such as taking certain medications or genetic in origin. The extent of the enlargement varies in different individuals and also within the same individuals. Aesthetics and effective plaque control is compromised and part of the objectives of treatment is to help in these aspects. (Copied from article).
    Matched MeSH terms: Hypertrophy
  19. Fulltext The effects of plyometric training on the muscle physical changes among long jumpers
    Prabhu Ragawan, Ruaibah Yazani Tengah
    Jurnal Sains Sukan & Pendidikan Jasmani, 2018;7(1):62-70.
    MyJurnal
    This study aim to examine the effectiveness of plyometric training on muscle physical changes. 24 long jumpers under 12 year old from Cameron Highland were involved in this study. 12 participants were in the control group and another 12 were assigned into treatment group. The training program was conducted twice a week for six weeks. Girth of thigh and calf muscles measurement were conducted during pre-test and post-test. The data were analyzed using descriptive analysis and two-way ANOVA test to determine the mean differences between groups, trial period and interaction of group and trial period. The findings showed that calf and thigh circumference show an improvement for both treatment and control group, in which the treatment group had gained significantly higher achievement. The two-way ANOVA test showed significant differences in enlargement of thigh muscle and calf muscle diameter between groups and trial period. As a conclusion, the plyometric exercises increased circumference of the thigh muscles and calf muscles among long jumpers. The implication of the study is that the proper plyometric training with an appropriate load for primary school athletes need to be implemented to achieve peak performance.
    Matched MeSH terms: Hypertrophy
  20. Essential thrombocytopenia
    Haridas G
    Journal of the Malaya Branch of the British Medical Association, 1940;4:198-204.
    Matched MeSH terms: Gingival Hypertrophy
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