MyMedR

Fulltext A benign presentation of primary ductal adenocarcinoma of lacrimal gland: A rare malignancy

Lau LL, Lung CK, Ahmad SS

Indian J Ophthalmol, 2015 Nov;63(11):856-8.

PMID: 26669339 DOI: 10.4103/0301-4738.171969

A 34-year-old patient with a swelling over the upper eyelid for nearly 1 year was seen in our clinic. The history, examination and investigations were suggestive of a benign lacrimal gland tumor. The tumor and lacrimal gland were resected. Subsequent histopathological examination revealed the tumor was a primary ductal adenocarcinoma of the lacrimal gland. This is a very rare tumor with less than half a dozen cases reported so far. This case report is being presented to highlight an unusual presentation of this rare malignancy.

Matched MeSH terms: Lacrimal Apparatus Diseases

Fulltext Intra-cranial metastatic lacrimal gland tumour

Wahab NA, Ramasamy U, George J, Madhavan M, Arif AR, Abdullah J

Med J Malaysia, 2006 Dec;61(5):641-3.

PMID: 17623971 MyJurnal

We report a case of an adult who presented with progressive swelling in the right eye with suggestive of intracranial lesion on imaging. Histopathological revealed a lacrimal gland malignant mixed tumour.

Matched MeSH terms: Lacrimal Apparatus Diseases/diagnosis; Lacrimal Apparatus Diseases/pathology; Lacrimal Apparatus Diseases/surgery*

Fulltext Radical resection for naso-lacrimal duct tumour

Vickers PG, Shue CL, Ahmad H

Med J Malaysia, 1999 Jun;54(2):277-9.

PMID: 10972044

Naso-lacrimal duct tumours are uncommon and present with epiphora and swelling. Since the naso-lacrimal duct is embedded in bone for the majority of its anatomical length, the late presentation of proptosis is due to orbital extension of the tumour. Radical surgical treatment is necessary to establish clear margins and facilitate reconstruction.

Matched MeSH terms: Lacrimal Apparatus Diseases/surgery*

Fulltext Lacrimal gland carcinoma

Sivanesan S, Chandran S

Med J Malaysia, 1982 Sep;37(3):257-60.

PMID: 6294490

Three consecutive cases of lacrimal gland carcinoma seen at the University Hospital during a twelve-year period are presented. One case was unusual, presenting at the age of sixteen years and developing metastases to the lungs. Adenoid cystic carcinoma is the commonest type of lacrimal malignancy and its clinico-pathological features and surgical management are discussed.

Matched MeSH terms: Lacrimal Apparatus Diseases/pathology*

Fulltext Primary lacrimal sac lymphoma with recurrence: a case report

Chai CK, Tang IP, Tan TY

Med J Malaysia, 2013 Jun;68(3):269-70.

PMID: 23749022 MyJurnal

Primary lacrimal sac lymphoma is rare. The common clinical features are epiphora and medial canthal swelling which mimic nasolacrimal duct obstruction. Histological examination is therefore important to avoid delay in diagnosis and treatment. We report a case of primary lacrimal sac lymphoma in a 72-year-old female who developed a metachronous tumour at the hard palate one year after excision of the lacrimal sac tumour.

Matched MeSH terms: Lacrimal Apparatus Diseases

Fulltext Investigation on the flexural properties and glass transition temperature of kenaf/epoxy composite filled with mesoporous silica for wind turbine applications

Chai Hua, T., Norkhairunnisa, M.

Pertanika Journal of Science & Technology, 2017;25(4):1261-1274.

MyJurnal

This research investigates the strength of kenaf or epoxy composite filled with mesoporous silica and
studies the hybrid effects between mesoporous silica or kenaf in epoxy matrix. The volume of kenaf
woven mat is maintained constantly at 7.2vol%, whereas proportion of epoxy is varied with inclusion of
mesoporous silica and silicon, keeping constant the volume of the composite at 67.5cm3. The proportion
of mesoporous silica is altered from 0.5vol%, 1.0vol%, 3.0vol% and 5.0vol%, while silicon is kept
constant at 3.0vol%. A total of 11 specimens were produced, each with its distinctive composition and
mechanical strengths. Variation of fillers composition affects the mechanical strengths of the composite.
SEM analysis shows that epoxy bonds well with silicon, kenaf and mesoporous silica. Some de-bonding
among the components is observed within the composite although there is also some tearing of fibres and
impregnation of epoxy within fibre, proving that the components have good interaction and do not act
individually. Flexural test shows that mesoporous silica improves the flexural strength of the composite,
where the highest value is 35.14MPa, obtained at 5.0vol% Mesoporous Silica in Kenaf/Epoxy (SiaK/
Ep). It also improves the flexural modulus, where the highest value is 1569.48MPa, obtained at 3.0vol%
SiaK/Ep. DMA result reveals that adding mesoporous silica increases the Tg of the composite produced.
Highest Tg is obtained at 0.5vol% Mesoporous Silica in Kenaf/Epoxy modofied Silicon (SiaK/Ep-Si)
with the value of 87.54°C.

Matched MeSH terms: Lacrimal Apparatus Diseases

Pleomorphic adenoma in the palpebral lobe of the lacrimal gland misdiagnosed as chalazion

Ramlee N, Ramli N, Tajudin LS

Orbit, 2007 Jun;26(2):137-9.

PMID: 17613864

We reported a case of pleomorphic adenoma of the lacrimal gland involving the palpebral lobe in young teenage girl of Asian origin. The presentation at young age group is rare, which initially misdiagnosed as a large chalazion. The benign tumor with its intact pseudocapsule was removed through lateral orbitotomy together with the suspicious looking orbital lobe.

Matched MeSH terms: Lacrimal Apparatus Diseases/diagnosis*; Lacrimal Apparatus Diseases/surgery

A recurrent nasopharyngeal carcinoma with lacrimal sac involvement: a case report

Tang IP, Periyannan P, Prepageran N, Shashinder S, Singh A, Bhagubhai PN

Eur J Cancer Care (Engl), 2011 Jan;20(1):93-5.

PMID: 20088917 DOI: 10.1111/j.1365-2354.2009.01147.x

We report a very rare case of recurrent nasopharyngeal carcinoma with local involvement of lacrimal sac. The patient was treated with chemotherapy and there was no recurrence noted after 1 year of follow-up.

Matched MeSH terms: Lacrimal Apparatus Diseases/pathology*; Lacrimal Apparatus Diseases/therapy

Primary non-Hodgkins lymphoma of the lacrimal sac: mortality-related epiphora

Maharajah KR, Hussein A, Mohamad H, Khan SA, At LS

Orbit, 2009;28(5):306-8.

PMID: 19874126 DOI: 10.3109/01676830903044346

We report a case of primary non-Hodgkins lymphoma of the lacrimal sac in a 60-year-old Asian lady, who presented with persistent epiphora and recurrent medial canthal swelling. Primary lymphoma of the lacrimal sac is rare and it can be easily misdiagnosed. Delayed in diagnosis may be related to mortality. To minimize the risk of overlooking specific pathology it is important to assess the appearance of the lacrimal sac and its surrounding structures intraoperatively. Biopsy of the lacrimal sac is required in cases where specific pathology is suspected.

Matched MeSH terms: Lacrimal Apparatus Diseases/etiology; Lacrimal Apparatus Diseases/mortality*

Dermoid cyst simulating recurrent dacryocystitis in a toddler

Tengku-Fatishah A, Abdullah B, Sanjeevan N, Nurul-Shuhada AH, Sharifah-Emilia TS, Haron J, et al.

Can J Ophthalmol, 2019 08;54(4):e196-e199.

PMID: 31358169 DOI: 10.1016/j.jcjo.2018.10.006

Matched MeSH terms: Lacrimal Apparatus Diseases/diagnosis*; Lacrimal Apparatus Diseases/surgery

Fulltext Extrapulmonary sarcoidosis: unusual cause of epiphora

Ramlee N, Ramli N, Liza-Sharmini AT

Singapore Med J, 2007 Jun;48(6):e168-70.

PMID: 17538739

Sarcoidosis is a multisystemic granulomatous disease of unknown aetiology mainly affecting African-Americans, Scandinavians, and the Irish. However, individuals of other races and ethnicities are still not immune. The clinical presentations vary widely with most patients having some respiratory problems. Though extrapulmonary sarcoidosis is no longer rare, sarcoidosis involving the lacrimal sac is an infrequently-reported problem. We present a case of sarcoidosis involving the lacrimal sac in a 42-year-old Malay woman who presented with epiphora. She was successfully treated with steroids and dacryocystorhinostomy. There was no evidence of systemic involvement. It is suggested that in an unusual presentation of sarcoidosis, a thorough search should be made for localisation of other sites, lungs in particular, even in the absence of respiratory complaints.

Matched MeSH terms: Lacrimal Apparatus Diseases/etiology*; Lacrimal Apparatus Diseases/pathology

Clinical and Imaging Features of Lacrimal Gland Involvement in Granulomatosis with Polyangiitis

Tan LT, Davagnanam I, Isa H, Rose GE, Verity DH, Pusey CD, et al.

Ophthalmology, 2015 Oct;122(10):2125-9.

PMID: 26233627 DOI: 10.1016/j.ophtha.2015.06.026

Lacrimal gland involvement in granulomatosis with polyangiitis (GPA) commonly accompanies orbital disease, but occasionally may be the sole presentation preceding any other organ manifestation or systemic disease. Diagnosis of orbital GPA, especially in patients with lacrimal involvement as the initial presentation, can be difficult because of nonspecific clinical features and lack of diagnostic specificity on histologic and antineutrophilic cytoplasmic antibody (ANCA) testing. Orbital GPA can be associated with a high morbidity from potential visual loss or rapid progression of latent systemic disease, making early diagnosis important. The purpose of this study was to describe the clinical and imaging features of patients with lacrimal gland involvement secondary to GPA and to compare them with those of other orbital inflammatory conditions in the lacrimal gland fossa.

Matched MeSH terms: Lacrimal Apparatus Diseases/diagnosis*; Lacrimal Apparatus Diseases/etiology; Lacrimal Apparatus Diseases/pathology

Fulltext Epiphora as the primary initial presentation for a huge sino-nasal osteoma: a rare presentation

Nadia Yaacob, Adil Hussein

Journal of Biomedical and Clinical Sciences, 2018;3(2):26-28.

MyJurnal

Sino-nasal osteoma is a common benign tumour of paranasal
sinuses and usually asymptomatic. Here, we presented a case of a huge sinonasal osteoma. Despite the large size of the tumour, the only presentation
was epiphora. There were no headache, facial pain or diplopia. Nasal
obstruction only occurred after involvement of the nasal cavity. In diagnosing
aetiology of the epiphora, sino-nasal pathology needed to be ruled out after
excluding ocular causes. Multidisciplinary approach between otolaryngology
(ORL) team and ophthalmology team was essential in managing the case.
The tumour was successfully removed surgically via endoscopic approach;
and dacryocystorhinostomy (DCR) was performed to alleviate the epiphora.

Matched MeSH terms: Lacrimal Apparatus Diseases

Fulltext The changes of meibomian glands, tear films, crystalline lens among early stage diabetes mellitus

Shanisha Rubiny A/P Vardi Veloo, Subhadeep Das

Journal of Optometry, Eye and Health Research, 2020;2(1):57-61.

MyJurnal

Diabetes mellitus is a condition of increase glucose concentration in blood plasma. Complication of diabetes mellitus are progressive and leads to several changes on ocular surface. Lack of data focusing on changes in ocular surface among early detect diabetes. Therefore, the aim of the study is to focus on the prevalence of changes in Meibomian glands, tear films and crystalline lens among early detect diabetes type 2. A descriptive cross sectional study was conducted to assess the grading of Meibomian glands, number of expressible glands, Tear-break up time (TBUT), schirmer’s test I , and crystalline lens in 100 eyes of 50 patients who has type 2 diabetes less than 5 years. Demographic information , medical and ocular history was recorded. Data was entered on SPSS version 25- descriptive analysis. The mean ± standard deviation for age was 51.08 ± 8.708 and the years of diabetes was 3.14 ± 1.498. The results stated, more people has MGD grade 1 with percentage of 39% . Besides, TBUT test has mean ± SD of 4.74 ± 1.404 and tear production with mean of 15.1± 8.650. There were 54% more patients has no changes on crystalline lens. Approximately, high prevalence in changes of Meibomian gland, and tear film while low prevalence on changes of crystalline lens among shorter duration diabetic patients.

Matched MeSH terms: Lacrimal Apparatus Diseases

Fulltext Inferior canaliculi punctal granuloma of the lacrimal system: a case report

Nur Aqilah S, Farizal A, Othmaliza O

Journal of Surgical Academia, 2016;6(1):39-42.

MyJurnal

Pyogenic granuloma of the eyes usually occurs after ocular surgery or inflammation related to the eyes, itself. This lesion is commonly related to procedures associated with chalazia, strabismus, or even enucleation. However, the incidence of pyogenic granuloma that arises directly from the lower canaliculi of the nasolacrimal system is rare and not being extensively reported. We report a case of an elderly lady who presented with pyogenic granuloma post EDCR with silicone stenting for left nasolacrimal duct obstruction. She presented with persistent left eye epiphora following procedure. The unusual site for pyogenic granuloma and it occurrence after EDCR raise the possibility that the condition is related to previous procedure and the material being used.

Matched MeSH terms: Lacrimal Apparatus Diseases

Fulltext Canaliculitis in supernumerary puncta and canaliculi

Yong KC, Kah TA, Annuar FH

Clin Pract, 2011 Jul 01;1(3):e59.

PMID: 24765320 DOI: 10.4081/cp.2011.e59

We report the first case of supernumerary puncta and canaliculi presented with canaliculitis. A-59 year-old gentleman presented with painful swelling of the left lower lid for a week, which was associated with epiphora. The swelling was confined to the nasal aspect of the left lower lid (0.5×0.5 mm) with inflamed overlying skin. Two puncta (0.5 mm apart) were noted. The outer punctum at the normal anatomical position was a cul-de-sac while the inner punctum it the caruncle was patent. We described the embryology leading to supernumerary puncta and canaliculi to explain the paradoxical patency of the abnormally located punctum as well as the pathomechanism leading to canaliculitis. The patient was treated with oral cloxacillin 500 mg, 6 hourly for 5 days; the cellulitis subsided after three days.

Matched MeSH terms: Lacrimal Apparatus Diseases

Nasolacrimal relapse of nasopharyngeal carcinoma

Sia KJ, Tang IP, Kong CK, Tan TY

J Laryngol Otol, 2012 Aug;126(8):847-50.

PMID: 22804860 DOI: 10.1017/S0022215112001272

To describe three rare cases of nasolacrimal relapse of nasopharyngeal carcinoma, and to discuss the route of tumour spread from nasopharynx to lacrimal system as well as the relevant computed tomography findings.

Matched MeSH terms: Lacrimal Apparatus Diseases/pathology*

Fulltext Powered endoscopic dacryocystorhinostomy with mucosal flaps without stenting

Harvinder S, Rosalind S, Philip R, Mallina S, Gurdeep S

Med J Malaysia, 2008 Aug;63(3):237-8.

PMID: 19248697 MyJurnal

Dacrycystorhinostomy (DCR) is a procedure performed to drain the lacrimal sac in cases of nasolacrimal duct obstruction or in chronic dacryocystitis. It can be performed externally or endoscopically. This is a prospective, nonrandomized study involving twenty-two consecutive patients (16 Females and 6 Males; mean age 45.54 y; range 18-74 y) who presented to the DCR clinic with epiphora secondary to nasolacrimal duct obstruction and recurrent infection. All patients underwent primary powered endoscopic DCR. A total of 24 procedures were performed using a standardized surgical technique. Post-operatively, symptom evaluation and endoscopic assessment of the newly created lacrimal ostium were done. Twenty-two of the 24 DCR's were patent after a mean follow-up of 21.5 months, yielding a success rate of 91.66%. Patency was assessed by symptomatic evaluation and endoscopic visualization at each post-operative visit. Two patients had complications, one orbital fat exposure and the other secondary haemmorhage. The two failures were due to synechiae formation. Therefore, powered endoscopic DCR with mucosal flaps without stenting has a success rate comparable to that achieved with stents and external DCR.

Matched MeSH terms: Lacrimal Apparatus Diseases/surgery*

Fulltext Evaluation of Ocular Surface Disease in Asian Patients with Primary Angle Closure

Ling TE, Othman K, Yan OP, Rashid RA, Tet CM, Yaakob A, et al.

Open Ophthalmol J, 2017;11:31-39.

PMID: 28400889 DOI: 10.2174/1874364101711010031

OBJECTIVE: To evaluate the incidence of ocular surface disease (OSD) and to determine the effects of topical pressure-lowering drugs on ocular surface disease in primary angle closure patients.

METHODS: This was a cross-sectional comparative study comparing primary angle closure glaucoma (PACG) patients (Group A) with primary angle closure and primary angle closure suspect (Group B). Group A was treated with topical pressure-lowering drugs; Group B was not. Data on ocular diagnosis and details of treatment were obtained from medical records. Ocular surface disease incidence was assessed using the Ocular Surface Disease Index (OSDI) questionnaire and from clinical signs using Schirmer's test, tear break-up time and corneal fluorescein stain. Predictive Analytic Software 20 and STATA analysis software were used for statistical analyses.

RESULTS: Group A demonstrated a higher rate of OSD (OSDI 52.3%, Schirmer's test 70.5%, tear break-up time (TBUT) 75%, corneal staining 77.3%) compared to Group B (OSDI 39.0%, Schirmer's test 73.2%, TBUT 58.5% and cornea staining 14.6%) except for Schirmer's test. There was a significant difference in mean score of OSDI (p=0.004), TBUT (p=0.008) and cornea staining (p<0.001) between two groups. Primary angle closure glaucoma treated with more than two medications and for more than three years had worse ocular surface disease parameters but without statistical significant difference.

CONCLUSION: Ocular surface disease is common in PACG patients treated with topical pressure-lowering drugs. Topical pressure-lowering drugs caused significant OSD symptoms and signs except for tear production in PACG patients. Thorough evaluation of ocular surface disease is important to ensure appropriate treatment and intervention in PACG patients.

Matched MeSH terms: Lacrimal Apparatus Diseases

Fulltext What lurks beneath: lacrimal gland adenocarcinoma dedifferentiation to sarcomatoid carcinoma

Farrah-Hani Imran, Muthukumaran, Guhan, Enda, Kelly, Jegan Thanabalan, Farizal Fadzil, Faridah Hanum

Journal of Surgical Academia, 2015;5(2):66-69.

MyJurnal

This was a case of a young lady presenting with 10 year history of a mass in the right eye. It was found to be an adenocarcinoma of the lacrimal gland from histopathological biopsy. She underwent wide excision, orbital exenteration and reconstruction with a free rectus abdominis flap. Unfortunately, she had a tumour recurrence which was not controlled by radiotherapy and a second excision. The behavior of the tumour was aggressive, resulting in widespread metastases. She passed away within a year of her presentation. Of note, the histopathology report from the second excision turned out to be sarcomatoid carcinoma. This is described in the literature as dedifferentiation, or high grade transformation (HGT). Occurrence of dedifferentiation in salivary gland tumours is well-established, but not as well-described in lacrimal gland tumours. In this case, there was a severely delayed presentation of a lacrimal gland adenocarcinoma in a young person, which underwent dedifferentiation into a sarcomatoid carcinoma. This phenomena is associated with aggressive tumour biology behavior and poor prognosis, despite surgery and radiotherapy.

Matched MeSH terms: Lacrimal Apparatus Diseases

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