MyMedR

Primary peritoneal carcinoma (PPC) is a rare tumor that is histologically and immunohistochemically indistinguishable from epithelial ovarian carcinoma. The diagnosis is usually made after excluding gross ovarian involvement or the ovarian involvement is only confined to the surface. A 68-year-old lady presented with right iliac fossa pain and increasing CA125. The CT scan showed bilateral pelvic adnexal masses with peritoneal deposits within the right side of abdomen. She was initially diagnosed as carcinomatosis peritonei from the omental cake removed after exploratory surgery. She was managed as advanced ovarian tumor with peritoneal metastasis and was then administered six cycles of chemotherapy. Surgical intervention included debulking surgery consisting of total abdominal hysterectomy, bilateral salpingooophorectomy and omentectomy and also with right hemicolectomy. The histopathological findings were of primary peritoneal serous carcinoma with only minimal involvement of the serosal surface of the right ovarian capsule. No microscopic invasion into underlying ovarian cortex and stroma was observed. Multiple tumor deposits were also seen over the right paratubal and paraovarian tissue, both parametrium as well as serosal surface of the terminal ileum and periappendicular tissue. Immunohistochemically, the malignant cells were positive to CA125, focally positive to CK7 and negative to CD20 and Calretinin. PPC is one of important differential diagnosis which needs to be considered in cases of advanced ovarian tumor, although the former can only be ascertained after excluding the ovarian involvement microscopically.

Matched MeSH terms: Ovarian Neoplasms/diagnosis; Peritoneal Neoplasms/diagnosis*

Fulltext Management of colorectal cancer--can we do better?

Gul YA

Med J Malaysia, 2008 Jun;63(2):89-90.

PMID: 18942289

Matched MeSH terms: Colorectal Neoplasms/diagnosis

Fulltext Solid pseudopapillary tumor of the pancreas in a young Malay woman

Ngui NKT

Med J Malaysia, 2004 Oct;59(4):555-7.

PMID: 15779596

Solid pseudopapillary tumors of the pancreas are very rare, low-grade malignant potentially curable neoplasms. Despite having non-specific symptomatology, they have typical features such as being more common in young women, and classically presenting as large abdominal masses. Accurate diagnosis is important because long-term survival hinges on complete resection of the tumor.

Matched MeSH terms: Pancreatic Neoplasms/diagnosis*

Lung cancer: II. Diagnostic methods

Saw Huat Seong, Ashoka Menon M

Med J Malaysia, 1979 Mar;33(3):235-42.

PMID: 522729

Matched MeSH terms: Lung Neoplasms/diagnosis*

Management of the pregnant mother with malignant conditions

Sivanesaratnam V

Curr Opin Obstet Gynecol, 2001 Apr;13(2):121-5.

PMID: 11315864

A malignancy discovered in pregnancy is often difficult to manage; the optimal maternal therapy has to be balanced with the fetal well-being. Generally, the cancer is managed as though the patient is not pregnant. For the various site-specific cancers, surgery is the main modality of treatment; this should be individualized. Chemotherapeutic agents are highly teratogenic in the first trimester, with some adverse effects when used after 12 weeks' gestation. The overall survival rate for pregnancy-associated breast cancer is poor; the reasons for this are discussed. For cervical cancer, delivery by caesarean section appears to be the method of choice, with significantly better survival rates compared with those who deliver vaginally. Other gynaecological and non-gynaecological malignancies are discussed.

Matched MeSH terms: Breast Neoplasms/diagnosis; Uterine Cervical Neoplasms/diagnosis; Ovarian Neoplasms/diagnosis; Uterine Neoplasms/diagnosis; Endometrial Neoplasms/diagnosis

Fulltext Infrasellar craniopharyngioma of the posterior nasal septum: a rare entity

Chiun KC, Tang IP, Tharumalingam V, Nurshaline Pauline HK

Med J Malaysia, 2012 Feb;67(1):131-2.

PMID: 22582569 MyJurnal

To report an unusual location of infrasellar craniopharyngioma in a peadiatric patient.

Matched MeSH terms: Nose Neoplasms/diagnosis*; Pituitary Neoplasms/diagnosis*

Fulltext Commentary: adherence and detection rates in colorectal cancer screening

Hilmi I, Goh KL

Aliment Pharmacol Ther, 2013 Jan;37(1):156-7; discussion 157-8.

PMID: 23205475 DOI: 10.1111/apt.12122

Matched MeSH terms: Neoplasms/diagnosis*; Colorectal Neoplasms/diagnosis*

A rare case of paediatric meningioma masquerading as intra-axial lesion

Tan LY, Tan AP

Med J Malaysia, 2018 12;73(6):439-440.

PMID: 30647227

Meningiomas are neoplasm arising from meningoepithelial cells, most commonly in the fifth to sixth decade of life. Meningiomas are rare in paediatric population, accounting for 0.4-4.1% of all paediatric tumours and less than 3% of paediatric brain tumours. However, meningiomas represent the most common dural based tumours in children. We describe a rare case of paediatric fibroblastic meningioma within the left middle cranial fossa masquerading as an intra-axial mass lesion. Our discussion will be centred on atypical features of paediatric meningiomas and differential diagnosis of extra-axial mass lesion in the paediatric population.

Matched MeSH terms: Meningeal Neoplasms/diagnosis*; Skull Base Neoplasms/diagnosis*

Meigs' syndrome: a case report and review of the literature

Fook CW

Med J Malaya, 1970 Sep;25(1):58-60.

PMID: 4250313

Matched MeSH terms: Abdominal Neoplasms/diagnosis; Pelvic Neoplasms/diagnosis

Strawberry Marks on Lip

Kanneppady SS, Kanneppady SK, Chaubal T, Bapat R, Pandurangappa R, Oo AM, et al.

Am J Med, 2019 04;132(4):e538-e539.

PMID: 30503886 DOI: 10.1016/j.amjmed.2018.11.019

Matched MeSH terms: Lip Neoplasms/diagnosis*

Retroperitoneal teratoma

Mohd Bahari HM, Haron A

Med J Malaysia, 1979 Mar;33(3):226-9.

PMID: 522727

Matched MeSH terms: Retroperitoneal Neoplasms/diagnosis*

Fulltext A rare case of middle mediastinal thymoma mimicking left lower lobe lung tumor

Venayaga K, Ooi JSM, Shabir B

Med J Malaysia, 2005 Oct;60(4):508-10.

PMID: 16570719

Matched MeSH terms: Lung Neoplasms/diagnosis*; Mediastinal Neoplasms/diagnosis*; Thymus Neoplasms/diagnosis*

Fulltext Sino-nasal hemangiopericytoma--a rare tumor

Vikneswaran T, Gendeh BS, Tan VES, Phang KS, Saravanan K

Med J Malaysia, 2005 Oct;60(4):485-8.

PMID: 16570712

Hemangiopericytoma is a very rare angiogenic tumor. In the nasal cavity, it can be considered malignant. It occurs in various parts of the body but those in the nasal cavity account for only 5% of total cases. Less than 200 cases have been reported worldwide involving the nose and paranasal sinuses. Due to its rarity a proper line of management has not been established to tackle this tumour. This article highlights two cases of hemangiopericytoma (HPC), one in an adult and the other in a child, presenting as an intranasal mass.

Matched MeSH terms: Nasopharyngeal Neoplasms/diagnosis*; Nose Neoplasms/diagnosis*; Paranasal Sinus Neoplasms/diagnosis

Fulltext Metastatic disease of the proximal femur

Faisham WI, Zulmi W, Biswal BM

Med J Malaysia, 2003 Mar;58(1):120-4.

PMID: 14556337

Since January 1999, ten patients had undergone surgical treatment for metastatic bony lesions of proximal femur at this centre. Seven of these patients were treated for complete pathological fractures, one for impending fracture and one for revision of internal fixation and loosening of hemiarthroplasty. Primary malignancies were located in breast in four cases, prostate in three and one in lung, thyroid and neurofibrosarcoma. Two patients had died within six months after surgery, four after 1 year while the remaining four were still alive. The mean duration of survival was eleven months. Nine patients had been ambulating pain free and there were no failure of reconstruction.

Matched MeSH terms: Bone Neoplasms/diagnosis; Breast Neoplasms/diagnosis; Lung Neoplasms/diagnosis; Prostatic Neoplasms/diagnosis; Thyroid Neoplasms/diagnosis

Palliative radiotherapy for advanced Cancer: Are we giving it to the right patient at the right time?

Syadwa AS, Anita ZB

Med J Malaysia, 2018 08;73(4):190-196.

PMID: 30121680 MyJurnal

AIM: Symptomatic relief following palliative radiotherapy for advanced cancers may take a few weeks up to a few months to achieve. Thus, accurate prognostication is important to avoid harm to these patients with limited lifespan. We conducted a retrospective cohort study to determine the median survival and 30-day mortality (30-DM) and factors associated with these parameters in our centre.

METHODS: Data from 585 eligible patients who received palliative radiotherapy between January 2012 and December 2014 were analysed. Median overall survival was calculated from the commencement of first fraction of the last course of radiotherapy to date of death or when censored. 30-DM was calculated as the proportion of patients who died within 30 days from treatment start date. Kaplan-Meier survival analysis was used to estimate survival. Chi-square test and logistic regression was used to assess the impact of potential prognostic factors on median survival and 30-DM.

RESULTS: The most common diagnoses were lung and breast cancers and most common irradiated sites were bone and brain. Median survival and 30-DM were 97 days and 22.7% respectively. Primary cancer, age, treatment course, performance status, systemic treatment post radiotherapy and intended radiotherapy treatment completed had an impact on median survival whereas mainly the latter three factors had an impact on 30-DM.

CONCLUSION: Median survival and factors affecting both survival and 30-DM in our study are comparable to others. However, a 30-DM rate of 22.7% is significantly higher compared to the literature. We need to better select patients who will benefit from palliative radiotherapy in our centre.

Matched MeSH terms: Breast Neoplasms/diagnosis; Lung Neoplasms/diagnosis; Neoplasms/diagnosis

Multinodular/plexiform schwannoma of the ulnar nerve

Lim CY, Low TH, Sivanoli R, Teh KK, Thuraisingham R

ANZ J Surg, 2014 Jan-Feb;84(1-2):93-4.

PMID: 24165375 DOI: 10.1111/ans.12231

Matched MeSH terms: Peripheral Nervous System Neoplasms/diagnosis*

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