MyMedR

Fulltext Management of colorectal cancer--can we do better?

Gul YA

Med J Malaysia, 2008 Jun;63(2):89-90.

PMID: 18942289

Matched MeSH terms: Colorectal Neoplasms/therapy*

Alloxan in the treatment of carcinoma of the liver

WILLIS GC, SIANG SC

Med J Malaya, 1960 Mar;14:166-76.

PMID: 13785569

Matched MeSH terms: Liver Neoplasms/therapy*

Fulltext Cutaneous metastases from head and neck squamous cell carcinoma

Poovaneswaran S, Paleri V, Charlton F, Dobrowsky W, Kelly C

Med J Malaysia, 2012 Aug;67(4):430-2.

PMID: 23082459 MyJurnal

The presence of cutaneous metastases in squamous cell carcinomas of the head and neck (SCCHN) is rare and associated with a dismal prognosis. It is vital to distinguish these lesions from direct invasion of the skin by SCCHN or primary cutaneous malignancies as the prognosis is vastly different and so is the management. In this case report, we present four cases of cutaneous metastases and also briefly review the literature pertaining to this phenomenon.

Matched MeSH terms: Hypopharyngeal Neoplasms/therapy; Laryngeal Neoplasms/therapy; Mouth Neoplasms/therapy; Skin Neoplasms/therapy; Tonsillar Neoplasms/therapy

Management of the pregnant mother with malignant conditions

Sivanesaratnam V

Curr Opin Obstet Gynecol, 2001 Apr;13(2):121-5.

PMID: 11315864

A malignancy discovered in pregnancy is often difficult to manage; the optimal maternal therapy has to be balanced with the fetal well-being. Generally, the cancer is managed as though the patient is not pregnant. For the various site-specific cancers, surgery is the main modality of treatment; this should be individualized. Chemotherapeutic agents are highly teratogenic in the first trimester, with some adverse effects when used after 12 weeks' gestation. The overall survival rate for pregnancy-associated breast cancer is poor; the reasons for this are discussed. For cervical cancer, delivery by caesarean section appears to be the method of choice, with significantly better survival rates compared with those who deliver vaginally. Other gynaecological and non-gynaecological malignancies are discussed.

Matched MeSH terms: Breast Neoplasms/therapy; Uterine Cervical Neoplasms/therapy; Ovarian Neoplasms/therapy; Uterine Neoplasms/therapy; Endometrial Neoplasms/therapy

Teratoma in infancy and childhood: a ten-year review at the University Hospital, Kuala Lumpur

Sinniah D, Prathap K, Somasundram K

Cancer, 1980 Aug 01;46(3):630-2.

PMID: 7397629

A ten-year review revealed a similarity in the incidence of teratoma in relation to other childhood tumors in Malaysian as compared with Caucasian children. The most common sites of origin were the sacropcoccygeal, gonadal, and retroperitoneal areas. The reason for the high incidence of retroperitoneal tumor in our series as compared with other countries is not clear. Late presentation and poor followup are associated with poor prognosis.

Matched MeSH terms: Abdominal Neoplasms/therapy; Mediastinal Neoplasms/therapy; Ovarian Neoplasms/therapy; Parotid Neoplasms/therapy; Retroperitoneal Neoplasms/therapy; Testicular Neoplasms/therapy

The management of gestational trophoblastic disease in developing countries such as Malaysia

Sivanesaratnam V

Int J Gynaecol Obstet, 1998 Apr;60 Suppl 1:S105-9.

PMID: 9833622 DOI: 10.1016/S0020-7292(98)80012-X

Gestational trophoblastic disease is a common gynaecological problem in Malaysia. The incidence of molar pregnancy is 2.8 per 1000 deliveries, being more common amongst the Chinese. The preferred method of evacuation is suction curettage; complete evacuation of the uterus was not achieved at the first attempt in 25 per cent of cases. Partial moles in our centre comprised 30 per cent of all moles. This is potentially malignant and needs follow-up for a complete mole. In the management of an invasive mole, chemotherapy should not be withheld in the presence of metastases and failure of regression of hCG. The role of prophylactic hysterectomy and prophylactic chemotherapy in the management of molar pregnancy is discussed "Selective preventive chemotherapy" in patients at "risk" appears appropriate. Chemotherapy remains the main modality of treatment for gestational trophoblastic tumours (GTT). We categorised our patients into low, medium and high-risk groups; survivals were 100, 98, and 61.7 percent respectively. These patients when categorised according to FIGO staging had survivals of 100, 80, 78.6 and 68.2 per cent respectively for stages 1, 2, 3 and 4 respectively. The reasons for the poor survival in the 'high-risk' group are discussed. Colour doppler blood flow studies are now being carried out; its role needs further evaluation. Surgery and radiotherapy have only a limited role in the management of these cases.

Matched MeSH terms: Trophoblastic Neoplasms/therapy*; Uterine Neoplasms/therapy*

Metastatic endodermal sinus tumor of cerebellum and brainstem

Sinniah D, Chee CP, Pathmanathan R, Nuruddin R

Med. Pediatr. Oncol., 1988;16(1):57-61.

PMID: 3340064

Matched MeSH terms: Brain Neoplasms/therapy; Cerebellar Neoplasms/therapy

The anti-idiotype vaccines for immunotherapy

Bhattacharya-Chatterjee M, Chatterjee SK, Foon KA

Curr. Opin. Mol. Ther., 2001 Feb;3(1):63-9.

PMID: 11249733

Certain anti-idiotypic antibodies that bind to the antigen-combining sites of antibodies can effectively mimic the three-dimensional structures and functions of the external antigens and can be used as surrogate antigens for active specific immunotherapy. Extensive studies in animal models have demonstrated the efficacy of these vaccines for triggering the immune system to induce specific and protective immunity against bacterial, viral and parasitic infections as well as tumors. Several monoclonal anti-idiotype antibodies that mimic distinct human tumor-associated antigens have been developed and characterized. Encouraging results have been obtained in recent clinical trials using these anti-idiotype antibodies as vaccines. In this article, we will review the current literature and discuss the potential of this novel therapeutic approach for various human cancers.

Matched MeSH terms: Breast Neoplasms/therapy; Lung Neoplasms/therapy; Neoplasms/therapy*; Colorectal Neoplasms/therapy

Fulltext Cancer in Malaysia--there is light at the end of the tunnel

Lim GCC

Med J Malaysia, 2003 Dec;58(5):632-5.

PMID: 15190645

Matched MeSH terms: Neoplasms/therapy

Indications and outcomes of reduced-toxicity hematopoietic stem cell transplantation in adult patients with hematological malignancies

Wahid SF

Int J Hematol, 2013 May;97(5):581-98.

PMID: 23585244 DOI: 10.1007/s12185-013-1313-0

Hematopoietic stem cell transplantation (HCT) utilizing non-myeloablative (NMA) and reduced-intensity conditioning (RIC) regimens (collectively referred to as reduced-toxicity HCT, RT-HCT) has become a viable therapeutic option for patients with hematological malignancies who are ineligible for standard myeloablative conditioning transplantation (MA-HCT). RT-HCT has been shown to induce stable engraftment with low toxicity, and to produce similar overall and progression-free survival (PFS) when compared to MA-HCT in acute myeloid leukemia and myelodysplastic syndrome. The best results for RT-HCT have been reported for patients with disease that is in remission, indolent and chemosensitive, and with a strong graft-versus-malignancy effect. Chronic graft-versus-host disease seems to correlate with a lower relapse rate and better PFS. RT-HCT is inferior when performed in poor risk or advanced disease, due to high relapse rates. A search for novel strategies that includes the most appropriate conditioning regimens and post-transplant immunomodulation protocols with more intensive anti-malignancy activity but limited toxicity is in progress. This review provides an update on the results of clinical studies of RT-HCT, and discusses possible indications and investigative strategies for improving the clinical outcomes of RT-HCT for the major hematological malignancies.

Matched MeSH terms: Hematologic Neoplasms/therapy*

Fulltext Polymodal therapy for high grade gliomas: a case report of favourable outcomes following intraoperative radiation therapy

Zamzuri I, Rahman GI, Muzaimi M, Jafri AM, Nik Ruzman NI, Lutfi YA, et al.

Med J Malaysia, 2012 Feb;67(1):121-2.

PMID: 22582564 MyJurnal

High grade gliomas, frequently with their infiltrative nature, often make the outcome from neurosurgical intervention alone unsatisfactory. It is recognized that adjuvant radiochemotherapy approaches offer an improved prognosis. For these reasons, we opted for surgical debulking, intraoperative radiation therapy (IORT) in combination with whole brain irradiation therapy and chemotherapy (temozolamide cycles) in the management of a 42 year-old lady with Glioblastoma Multiforme (GBM). Her troublesome symptoms improved after 3 months of this polymodal therapy and remained independently functional for more than two years.

Matched MeSH terms: Brain Neoplasms/therapy*

Qigong in cancer care: a systematic review and construct analysis of effective Qigong therapy

Klein PJ, Schneider R, Rhoads CJ

Support Care Cancer, 2016 07;24(7):3209-22.

PMID: 27044279 DOI: 10.1007/s00520-016-3201-7

PURPOSE: This review (a) assesses the strength of evidence addressing Qigong therapy in supportive cancer care and (b) provides insights for definition of effective Qigong therapy in supportive cancer care.

METHODS: This mixed-methods study includes (a) a systematic review of randomized clinical trials (RCTs) following PRISMA guidelines and (b) a constant-comparative qualitative analysis of effective intervention protocols.

RESULTS: Eleven published randomized clinical trials were reviewed. A total of 831 individuals were studied. Geographic settings include the USA, Australia, China, Hong Kong, and Malaysia. Qigong therapy was found to have positive effects on the cancer-specific QOL, fatigue, immune function, and cortisol levels of individuals with cancer. Qigong therapy protocols varied supporting a plurality of styles. Qualitative analyses identified common programming constructs. Content constructs included exercise (gentle, integrated, repetitious, flowing, weight-bearing movements), breath regulation, mindfulness and meditation, energy cultivation including self-massage, and emphasis on relaxation. Logistic constructs included delivery by qualified instructors, home practice, and accommodation for impaired activity tolerance.

CONCLUSIONS: There is global interest and a growing body of research providing evidence of therapeutic effect of Qigong therapy in supportive cancer care. While Qigong therapy protocols vary in style, construct commonalities do exist. Knowledge of the common constructs among effective programs revealed in this research may be used to guide future research intervention protocol and community programming design and development.

Matched MeSH terms: Neoplasms/therapy*

Fulltext Recent advances in the diagnosis and treatment of lung cancer

Liam CK, Lim KH, Wong MM

Med J Malaysia, 2001 Dec;56(4):514-31; quiz 532.

PMID: 12014776

Matched MeSH terms: Lung Neoplasms/therapy*

Gaining Insights on Nasopharyngeal Carcinoma Treatment Outcome Using Clinical Data Mining Techniques

Ghaibeh AA, Kasem A, Ng XJ, Nair HLK, Hirose J, Thiruchelvam V

Stud Health Technol Inform, 2018;247:386-390.

PMID: 29677988

The analysis of Electronic Health Records (EHRs) is attracting a lot of research attention in the medical informatics domain. Hospitals and medical institutes started to use data mining techniques to gain new insights from the massive amounts of data that can be made available through EHRs. Researchers in the medical field have often used descriptive statistics and classical statistical methods to prove assumed medical hypotheses. However, discovering new insights from large amounts of data solely based on experts' observations is difficult. Using data mining techniques and visualizations, practitioners can find hidden knowledge, identify interesting patterns, or formulate new hypotheses to be further investigated. This paper describes a work in progress on using data mining methods to analyze clinical data of Nasopharyngeal Carcinoma (NPC) cancer patients. NPC is the fifth most common cancer among Malaysians, and the data analyzed in this study was collected from three states in Malaysia (Kuala Lumpur, Sabah and Sarawak), and is considered to be the largest up-to-date dataset of its kind. This research is addressing the issue of cancer recurrence after the completion of radiotherapy and chemotherapy treatment. We describe the procedure, problems, and insights gained during the process.

Matched MeSH terms: Nasopharyngeal Neoplasms/therapy*

Treatment of pituitary adenomas: a study of 66 cases

Arumugasamy N, Lestina FA, Bucy PC

Med J Malaya, 1971 Sep;26(1):3-14.

PMID: 4258574

Matched MeSH terms: Pituitary Neoplasms/therapy*

Development of oncolytic viruses for cancer therapy

Abd-Aziz N, Poh CL

Transl Res, 2021 11;237:98-123.

PMID: 33905949 DOI: 10.1016/j.trsl.2021.04.008

Oncolytic virotherapy is a therapeutic approach that uses replication-competent viruses to kill cancers. The ability of oncolytic viruses to selectively replicate in cancer cells leads to direct cell lysis and induction of anticancer immune response. Like other anticancer therapies, oncolytic virotherapy has several limitations such as viral delivery to the target, penetration into the tumor mass, and antiviral immune responses. This review provides an insight into the different characteristics of oncolytic viruses (natural and genetically modified) that contribute to effective applications of oncolytic virotherapy in preclinical and clinical trials, and strategies to overcome the limitations. The potential of oncolytic virotherapy combining with other conventional treatments or cancer immunotherapies involving immune checkpoint inhibitors and CAR-T therapy could form part of future multimodality treatment strategies.

Matched MeSH terms: Neoplasms/therapy*

Fulltext Exploring the link between human papilloma virus and oral and oropharyngeal cancers

Khode SR, Dwivedi RC, Rhys-Evans P, Kazi R

J Cancer Res Ther, 2014 Jul-Sep;10(3):492-8.

PMID: 25313727 DOI: 10.4103/0973-1482.138213

Squamous cell carcinoma involving the oral cavity (OC) and oropharynx regions are a major cause of morbidity and mortality world-wide. The recent discovery of a strong association between human papilloma virus (HPV) infection and OC and oropharyngeal (OP) cancer has prompted world-wide research into the exact etiology and pathogenesis of these cancers in relation to the HPV. HPV-positive OC/OP cancers generally present at a relatively advanced stage (by virtue of cervical nodal involvement) and are more commonly seen in younger patients without significant exposure to alcohol or tobacco. These factors are implicated in prognosis, regardless of HPV association. In this article, we review the biology and epidemiology, risk factors, association, molecular analyses, treatment response and prognosis of HPV-related cancers. Role of HPV vaccination in HPV-related OC/OP cancers has also been discussed.

Matched MeSH terms: Mouth Neoplasms/therapy; Oropharyngeal Neoplasms/therapy

Fulltext Asian Society of Gynecologic Oncology International Workshop 2014

Park JY, Ngan HY, Park W, Cao Z, Wu X, Ju W, et al.

J Gynecol Oncol, 2015 Jan;26(1):68-74.

PMID: 25609163 DOI: 10.3802/jgo.2015.26.1.68

The Asian Society of Gynecologic Oncology International Workshop 2014 on gynecologic oncology was held in Asan Medical Center, Seoul, Korea on the 23rd to 24th August 2014. A total of 179 participants from 17 countries participated in the workshop, and the up-to-date findings on the management of gynecologic cancers were presented and discussed. This meeting focused on the new trends in the management of cervical cancer, fertility-sparing management of gynecologic cancers, surgical management of gynecologic cancers, and recent advances in translational research on gynecologic cancers.

Matched MeSH terms: Uterine Cervical Neoplasms/therapy; Ovarian Neoplasms/therapy

Cardiac metastasis: a rare involvement of primitive neuroectodermal tumour of the lung

Ngow HA, Wan Khairina WM

Pathol Oncol Res, 2011 Sep;17(3):771-4.

PMID: 21213128 DOI: 10.1007/s12253-010-9328-9

A 15 year-old adolescent was referred with 2 month history of worsening of breathlessness and haemoptysis. He also reported constitutional symptoms of fever, poor appetite and weight loss. The chest roentgenogram showed a massive right pleural effusion with apparent cardiomegaly. The cardiac silhouette over the right heart border was obliterated and the mediastinum was widened. Computed tomogram of the thorax showed a bulky heterogeneous mass in the right lung with extension to the heart. Subsequent CT guided lung biopsy revealed Primitive Neuroectodermal tumour (PNET). Here, we illustrate the clinical course of an aggressive pulmonary PNET with lethal cardiac metastasis.

Matched MeSH terms: Heart Neoplasms/therapy; Lung Neoplasms/therapy

Fulltext Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines

Ghashm AA, Othman NH, Khattak MN, Ismail NM, Saini R

BMC Complement Altern Med, 2010;10:49.

PMID: 20840769 DOI: 10.1186/1472-6882-10-49

The treatment of oral squamous cell carcinomas (OSCC) and human osteosarcoma (HOS) includes surgery and/or radiotherapy which often lead to reduced quality of life. This study was aimed to study the antiproliferative activity of local honey (Tualang) on OSCC and HOS cell lines.

Matched MeSH terms: Bone Neoplasms/therapy*; Mouth Neoplasms/therapy*

Displaying publications 1 - 20 of 357 in total