MyMedR

Evidence of an interaction between nifedipine and nafcillin in humans

Lang CC, Jamal SK, Mohamed Z, Mustafa MR, Mustafa AM, Lee TC

Br J Clin Pharmacol, 2003 Jun;55(6):588-90.

AIMS: Nafcillin (Wyeth Laboratories, Philadelphia, PA, USA) has been reported to induce the metabolism of cyclosporin and warfarin, which are known substrates of cytochrome P-450 (CYP). However, there has not been any report to date on its possible interaction with nifedipine, an index substrate of the enzyme, CYP3A4.

METHODS: Nine healthy normotensive subjects participated in this randomized placebo-controlled two-way crossover study examining the effects of 5 days' pretreatment of nafcillin 500 mg or placebo four times daily on the pharmacokinetics of an oral dose of nifedipine 10 mg. Plasma nifedipine concentrations were measured by gas chromatography-mass spectro.

RESULTS: The area under the plasma nifedipine concentration-time curve (AUC0-alpha) in nafcillin-pretreated subjects (80.9 +/- 32.9 micro g l-1 h-1) was significantly decreased compared with subjects who received only nifedipine (216.4 +/- 93.2 micro g l-1 h-1) (P < 0.001). Total plasma clearance of nifedipine (CL/F) was significantly increased with nafcillin pretreatment (138.5 +/- 42.0 l h-1 vs 56.5 +/- 32.0 l h-1) (P < 0.002).

CONCLUSIONS: The results show that nafcillin pretreatment markedly increased the clearance of nifedipine and suggest that nafcillin is a potent inducer of CYP enzyme.

Matched MeSH terms: Penicillins/blood; Penicillins/pharmacokinetics*

Fulltext Diphtheria: experience in a general hospital

Tee LK

Med J Malaysia, 1989 Mar;44(1):41-4.

PMID: 2516602

A review of patients with diphtheria seen in the Paediatric Unit, Alor Star General Hospital, from January 1985-March 1987 is reported. Their clinical presentation, diagnosis, treatment and outcome were analysed and discussed. Clinical awareness regarding the diagnosis of diphtheria is emphasised.

Matched MeSH terms: Penicillins/therapeutic use

Penicillin in the treatment of 84 cases of leptospirosis in Malaya

MACKAY-DICK J, ROBINSON JF

J R Army Med Corps, 1957 Oct;103(4):186-97.

PMID: 13481991

Matched MeSH terms: Penicillins/therapeutic use*

[Combinational Overexpression of Foxa3 and Hnf4α Enhance the Proliferation and Prolong the Functional Maintenance of Primary Hepatocytes]

Fan JY, Dama G, Liu YL, Guo WY, Lin JT

Mol Biol (Mosk), 2023;57(4):668-670.

PMID: 37528786

In an in vitro culture system, primary hepatocytes usually display a low proliferation capacity, accompanied with a decrease of viability and a loss of hepatocyte-specific functions. Previous studies have demonstrated that the combination introductions of certain hepatocyte-specific transcription factors are able to convert fibroblasts into functional hepatocyte-like cells. However, such combinational usage of transcription factors in primary hepatocytes culture has not yet sufficiently studied. The forkhead box protein A3 (FoxA3) and hepatocyte nuclear factor 4α (Hnf4α) are liver-enriched transcription factors that play vital roles in the differentiation, and maintenance of hepatocytes. Thus, we simultaneously overexpressed the two genes, Foxa3 and Hnf4α, in rat hepatocytes and observed that the combinational augmentation of these two transcription factors have enhanced the proliferation and stabilized the hepatocyte-specific functions of primary hepatocytes over a long-term culture period.

Matched MeSH terms: Penicillins/metabolism

Tumor-responsive dynamic nanoassemblies for targeted imaging, therapy and microenvironment manipulation

Low LE, Wu J, Lee J, Tey BT, Goh BH, Gao J, et al.

J Control Release, 2020 Aug 10;324:69-103.

PMID: 32423874 DOI: 10.1016/j.jconrel.2020.05.014

The recent designs of dynamic nanoassemblies exploiting the tumor-targeting properties have received increasing attention for tumor imaging and therapy due to their tumor-specific delivery and enhanced antitumor efficacy. However, these designs are mainly focused on the macroscopic tumor therapeutic effect, while the nano-bio interactions in the tumor microenvironment (TME) remain poorly understood. This review aims to provide an overview of the development of tumor-responsive nanoassemblies towards the imaging, therapy and TME modulation in the tumor site. The tumor biology leading to TME formation and the potential TME properties for the practicable design of tumor-targeting nanoassemblies has been outlined. Furthermore, the various approaches for TME modification and the realization via dynamic nanoassemblies for enhanced tumor therapy were reviewed. Lastly, the prospects of these methods were briefly discussed. These strategies may inspire the development of new combinational cancer therapeutics.

Matched MeSH terms: Penicillins

Severe leptospirosis with unusual manifestation

Othman N, Intan HI, Yip CW, Alias M, Amran F

J Trop Pediatr, 2007 Feb;53(1):55-8.

PMID: 17237115

We report a case of an 8-year-old aborigine boy referred to our hospital for respiratory insufficiency with skin eruptions over the trunk and limbs. The skin condition was diagnosed as acquired ichthyosis. He also had a non-bleeding form of disseminated intravascular coagulopathy. Radiograph of the lungs showed bilateral perihilar opacities with bilateral pleural effusion. The diagnosis of leptospirosis was confirmed by a 4-fold rise in microagglutinating titre and polymerase chain reaction assay.

Matched MeSH terms: Penicillins/therapeutic use

Fulltext The Jarisch-Herxheimer reaction in ocular syphilis

Fathilah J, Choo MM

Med J Malaysia, 2003 Aug;58(3):437-9.

PMID: 14750386

A patient with ocular syphilis is presented. She experienced deterioration in vision following the commencement of treatment due to a Jarisch-Herxheimer reaction. This is a transient febrile illness that can occur in patients after the first adequate dose of an anti-microbial drug to treat infectious diseases such as syphilis, Lyme disease and relapsing fever. However, a Jarisch-Herxheimer reaction occurring in a patient receiving treatment for ocular syphilis can be serious, resulting in the rapid loss of vision.

Matched MeSH terms: Penicillins/adverse effects*

A case of madura foot successfully treated with large doses of intravenous crystalline penicillin

Geh GS

Med J Malaya, 1969 Dec;24(2):147-50.

PMID: 4244141

Matched MeSH terms: Penicillins/therapeutic use*

Purulent meningitis in childhood

Lee EI, Khoo BH, Puthucheary SD, Thong ML

Med J Malaysia, 1977 Dec;32(2):114-9.

PMID: 26858

Matched MeSH terms: Penicillins/therapeutic use

MELIOIDOSIS: REPORT ON A FATAL CASE IN A BRITISH SOLDIER

MONTGOMERY R

J R Army Med Corps, 1963;109:223-7.

PMID: 14078072

Matched MeSH terms: Penicillins*

Management of infective endocarditis in pregnancy

Jeyamalar R, Sivanesaratnam V

Aust N Z J Obstet Gynaecol, 1991 May;31(2):123-4.

PMID: 1930032

Matched MeSH terms: Penicillins/administration & dosage; Penicillins/therapeutic use*

Fulltext In vitro properties of designed antimicrobial peptides that exhibit potent antipneumococcal activity and produces synergism in combination with penicillin

Le CF, Yusof MY, Hassan H, Sekaran SD

Sci Rep, 2015;5:9761.

PMID: 25985150 DOI: 10.1038/srep09761

Antimicrobial peptides (AMPs) represent a promising class of novel antimicrobial agents owing to their potent antimicrobial activity. In this study, two lead peptides from unrelated classes of AMPs were systematically hybridized into a series of five hybrid peptides (DM1-DM5) with conserved N- and C-termini. This approach allows sequence bridging of two highly dissimilar AMPs and enables sequence-activity relationship be detailed down to single amino acid level. Presence of specific amino acids and physicochemical properties were used to describe the antipneumococcal activity of these hybrids. Results obtained suggested that cell wall and/or membrane targeting could be the principal mechanism exerted by the hybrids leading to microbial cell killing. Moreover, the pneumocidal rate was greater than penicillin (PEN). Combination treatment with both DMs and PEN produced synergism. The hybrids were also broad spectrum against multiple common clinical bacteria. Sequence analysis showed that presence of specific residues has a major role in affecting the antimicrobial and cell toxicity of the hybrids than physicochemical properties. Future studies should continue to investigate the mechanisms of actions, in vivo therapeutic potential, and improve rational peptide design based on the current strategy.

Matched MeSH terms: Penicillins

Draft Genome Sequence of a Highly Resistant Streptococcus pneumoniae Serotype 15A Strain Isolated from Blood

Arushothy R, Ahmad N, Amran F, Hashim R, Samsuddin N, Che Azih CR

Genome Announc, 2018 Apr 19;6(16).

PMID: 29674530 DOI: 10.1128/genomeA.00167-18

After the introduction of the pneumococcal conjugate vaccine in Malaysia in recent years, the emergence of nonvaccine serotypes is of concern, particularly the antibiotic-resistant strains, with an increase specifically in serotype 15A. Here, we report the draft genome sequence of Streptococcus pneumoniae strain SS40_16, isolated from the blood sample of a 19-month-old female in 2016. SS40_16 is a multidrug-resistant strain with resistance to penicillin (MIC, ≥2 µg/ml), tetracycline, and trimethoprim-sulfamethoxazole. The strain belongs to serotype 15A and sequence type 1591 (ST1591).

Matched MeSH terms: Penicillins

Fulltext Lemierre syndrome

Lim AL, Pua KC

Med J Malaysia, 2012 Jun;67(3):340-1.

PMID: 23082433 MyJurnal

Lemierre syndrome is an uncommon disease which commonly arise from acute bacterial oropharyngeal infection. This disease was first described in 1900 by Courmont and Cade Lemierre. It is commonly caused by Fusobacterium necrophorum. Lemierre syndrome has been reported to be serious and potentially fatal in the preantibiotic era. It is characterized by an oropharyngeal infection leading to secondary septic thrombophlebitis of the internal jugular vein with embolization to the lungs and other organs. The incidence has become relatively rare at present and is usually only diagnosed when unsuspected culture results are available. We report a case of Lemierre syndrome which was recently diagnosed in our centre.

Matched MeSH terms: Penicillins/therapeutic use*

Rectal microscopy in men - expensive, time consuming and inappropriate

Waters L, Worthen E, O'mahony C

Int J STD AIDS, 2006 Oct;17(10):710.

PMID: 17059644

Matched MeSH terms: Penicillins/pharmacology*

Fulltext Actinomyces infection of the mastoid: a rare entity

Subha ST, Raman R, Cheah PL, Soo Hoo TS

Med J Malaysia, 2004 Dec;59(5):680-1.

PMID: 15889574

A rare case of mastoid infection caused by actinomyces israelii is presented. This patient underwent exploratory mastoidectomy followed by long term oral pencillin. She responded well to the treatment and has been asymptomatic on follow up to date.

Matched MeSH terms: Penicillins/therapeutic use

The patient who had a picnic at a waterfall and presented with haemoptysis and renal failure

Thiruventhiran T, Tan SY

Nephrol Dial Transplant, 2000 May;15(5):727-8.

PMID: 10809822

Matched MeSH terms: Penicillins/therapeutic use

Antimicrobial resistance in Streptococcus pneumoniae: an overview

Appelbaum PC

Clin Infect Dis, 1992 Jul;15(1):77-83.

PMID: 1617076

Clinical resistance to penicillin in Streptococcus pneumoniae was first reported by researchers in Boston in 1965; subsequently, this phenomenon was reported from Australia (1967) and South Africa (1977). Since these early reports, penicillin resistance has been encountered with increasing frequency in strains of S. pneumoniae from around the world. In South Africa strains resistant to penicillin and chloramphenicol as well as multiresistant strains have been isolated. Similar patterns of resistance have been reported from Spain. Preliminary evidence points to a high prevalence of resistant pneumococci in Hungary, other countries of Eastern Europe, and some countries in other areas of Europe, notably France. In the United States most reports of resistant pneumococci come from Alaska and the South, but resistance is increasing in other states and in Canada. Pneumococcal resistance has also been described in Zambia, Japan, Malaysia, Pakistan, Bangladesh, Chile, and Brazil; information from other African, Asian, and South American countries is not available. The rising prevalence of penicillin-resistant pneumococci worldwide mandates selective susceptibility testing and epidemiological investigations during outbreaks.

Matched MeSH terms: Penicillins/history

Fulltext A case of empyema thoracis caused by actinomycosis

Hooi LN, Na BS, Sin KS

Med J Malaysia, 1992 Dec;47(4):311-5.

PMID: 1303486

A female patient who presented with left empyema thoracis caused by Actinomyces odontolyticus is reported. She responded to treatment with penicillin and metronidazole but after 3 weeks developed leucopenia complicated by gram-negative septicaemia. Leucopenia improved rapidly on withdrawal of metronidazole. Treatment was continued with a prolonged course of penicillin and she made an uneventful recovery.

Matched MeSH terms: Penicillins/therapeutic use

Actinomycetic corneal ulcer

Singh M, Kaur B

Eye (Lond), 1989;3 ( Pt 4):460-2.

PMID: 2606221

A rare case of keratoactinomycosis developing in the absence of any known ocular trauma is described. It showed a dramatic response to penicillin therapy. Steroids should be cautiously used in the presence of active corneal disease. This case highlights the importance of repeated examination of corneal scrapings.

Matched MeSH terms: Penicillins/therapeutic use

Displaying publications 1 - 20 of 93 in total