Displaying publications 1 - 20 of 31 in total

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  1. Abdul Hadi MFR, Abdullah AN, Hashikin NAA, Ying CK, Yeong CH, Yoon TL, et al.
    Med Phys, 2022 Dec;49(12):7742-7753.
    PMID: 36098271 DOI: 10.1002/mp.15980
    PURPOSE: Monte Carlo (MC) simulation is an important technique that can help design advanced and challenging experimental setups. GATE (Geant4 application for tomographic emission) is a useful simulation toolkit for applications in nuclear medicine. Transarterial radioembolization is a treatment for liver cancer, where microspheres embedded with yttrium-90 (90 Y) are administered intra-arterially to the tumor. Personalized dosimetry for this treatment may provide higher dosimetry accuracy compared to the conventional partition model (PM) calculation. However, incorporation of three-dimensional tomographic input data into MC simulation is an intricate process. In this article, 3D Slicer, free and open-source software, was utilized for the incorporation of patient tomographic images into GATE to demonstrate the feasibility of personalized dosimetry in hepatic radioembolization with 90 Y.

    METHODS: In this article, the steps involved in importing, segmenting, and registering tomographic images using 3D Slicer were thoroughly described, before importing them into GATE for MC simulation. The absorbed doses estimated using GATE were then compared with that of PM. SlicerRT, a 3D Slicer extension, was then used to visualize the isodose from the MC simulation.

    RESULTS: A workflow diagram consisting of all the steps taken in the utilization of 3D Slicer for personalized dosimetry in 90 Y radioembolization has been presented in this article. In comparison to the MC simulation, the absorbed doses to the tumor and normal liver were overestimated by PM by 105.55% and 20.23%, respectively, whereas for lungs, the absorbed dose estimated by PM was underestimated by 25.32%. These values were supported by the isodose distribution obtained via SlicerRT, suggesting the presence of beta particles outside the volumes of interest. These findings demonstrate the importance of personalized dosimetry for a more accurate absorbed dose estimation compared to PM.

    CONCLUSION: The methodology provided in this study can assist users (especially students or researchers who are new to MC simulation) in navigating intricate steps required in the importation of tomographic data for MC simulation. These steps can also be utilized for other radiation therapy related applications, not necessarily limited to internal dosimetry.

    Matched MeSH terms: Radiometry/methods
  2. Banjade DP, Tajuddin AA, Shukri A
    Appl Radiat Isot, 2001 Sep;55(3):297-302.
    PMID: 11515650
    Previous scattering and depth-dose investigations involving use of the Malaysian hardwood Rhizophora spp have shown this medium to produce good agreement with measurements made in water. Present study extends the comparison, now including measurements of percentage depth-dose made for photons at 6MV and 5 and 12MeV electron beams. For the 6 MV photon and 5 MeV electron beams, discrepancies between percentage depth-dose for Rhizophora spp and water, at all depths, are found to be within 2.6 and 2.4% respectively. At 12 MeV electron energies, measured percentage depth-doses in Rhizophora spp beyond 3.5cm depth are found to be in significant discord with those for water. The absorbed dose in water measured in Rhizophora spp at d(max) for all three beams produces discrepancies of no more than 1.1% when compared with measurements made in water.
    Matched MeSH terms: Radiometry/methods*
  3. Wahib NB, Abdul Sani SF, Ramli A, Ismail SS, Abdul Jabar MH, Khandaker MU, et al.
    Radiat Environ Biophys, 2020 08;59(3):523-537.
    PMID: 32462382 DOI: 10.1007/s00411-020-00846-x
    Accidents resulting in widespread dispersal of radioactive materials have given rise to a need for materials that are convenient in allowing individual dose assessment. The present study examines natural Dead Sea salt adopted as a model thermoluminescence dosimetry system. Samples were prepared in two different forms, loose-raw and loose-ground, subsequently exposed to 60Co gamma-rays, delivering doses in the range 2-10 Gy. Key thermoluminescence (TL) properties were examined, including glow curves, dose response, sensitivity, reproducibility and fading. Glow curves shapes were found to be independent of given dose, prominent TL peaks for the raw and ground samples appearing in the temperature ranges 361-385 ºC and 366-401 ºC, respectively. The deconvolution of glow curves has been undertaken using GlowFit, resulting in ten overlapping first-order kinetic glow peaks. For both sample forms, the integrated TL yield displays linearity of response with dose, the loose-raw salt showing some 2.5 × the sensitivity of the ground salt. The samples showed similar degrees of fading, with respective residual signals 28 days post-irradiation of 66% and 62% for the ground and raw forms respectively; conversely, confronted by light-induced fading the respective signal losses were 62% and 80%. The effective atomic number of the Dead Sea salt of 16.3 is comparable to that of TLD-200 (Zeff 16.3), suitable as an environmental radiation monitor in accident situations but requiring careful calibration in the reconstruction of soft tissue dose (soft tissue Zeff 7.2). Sample luminescence studies were carried out via Raman and Photoluminescence spectroscopy as well as X-ray diffraction, ionizing radiation dependent variation in lattice structure being found to influence TL response.
    Matched MeSH terms: Radiometry/methods*
  4. Wahib NB, Khandaker MU, Aqilah Binti Mohamad Ramli N, Sani SFA, Bradley DA
    Appl Radiat Isot, 2019 Jun;148:218-224.
    PMID: 31003071 DOI: 10.1016/j.apradiso.2019.04.001
    Study has been made of the thermoluminescence (TL) yield of various glass-based commercial kitchenware (Reko-China, Skoja-France, Godis-China, Glass Tum-Malaysia, Lodrat-France). Interest focuses on their potential for retrospective dosimetry. Use was made of a60Co gamma-ray irradiator, delivering doses in the range 2-10 Gy. Results for the various media show all the glassware brands to yield linearity of response against dose, with a lower limit of detection of ∼0.06 and ∼0.08 Gy for loose and compact powdered samples. Among all of the brands under study, the Lodrat glassware provides the greatest sensitivity, at 6.0 E+02 nC g-1 Gy-1 and 1.5E+03 nC g-1 Gy-1 for compact- and loose-powdered forms respectively. This is sufficiently sensitive to allow its use as a TL material for accident dosimetry (2 Gy being the threshold dose for the onset of a number of deterministic biological effects, including skin erythema and sterility). Energy Dispersive X-ray (EDX) analyses have been conducted, showing the presence of a number of impurities (including C, O, Na, Mg, Al, Si, Ca and Br). Fading of the irradiated glasses show the amount of better than 3% and 5% of the stored energy for both loose and compact powdered samples within 9 days post irradiation. As such, commercial kitchenware glass has the potential to act as relatively good TL material for gamma radiation dosimetry at accident levels. This is the first endeavour reporting the TL properties of low cost commercial kitchenware glasses for gamma-ray doses in the few Gy range, literature existing for doses from 8 Gy to 200 Gy.
    Matched MeSH terms: Radiometry/methods*
  5. Hashim AK, Hatif AR, Ahmed NM, Wadi IA, Al Qaaod AA
    Appl Radiat Isot, 2021 Jan;167:109410.
    PMID: 33065401 DOI: 10.1016/j.apradiso.2020.109410
    Radon and progeny concentration measurements in various drink samples are intrinsically important for assessing the health risks resulting from daily consumption of these drinks. In this study the comparison between two Solid State Nuclear Track Detectors (SSNTDs), the CR-39 and the CN-85 has been conducted for the purpose of evaluating the radon concentration, annual effective dose, the rate of exhalation of radon and the effective radium content in thirty-two different samples of soft drink, water, and milk available in the local Iraq markets. The results showed that there are significant differences in the measurement results for the two detectors. The annual effective dose of the investigated samples is still below the limit of International Commission on Radiological Protection (ICRP) recommendation in the measurements of both detectors.
    Matched MeSH terms: Radiometry/methods
  6. Samson DO, Aziz MZA, Shukri A, Mat Jafri MZ, Hashim R, Zuber SH, et al.
    Health Phys, 2023 Aug 01;125(2):77-91.
    PMID: 36826380 DOI: 10.1097/HP.0000000000001688
    The current study was undertaken to investigate the radiological and dosimetric parameters of natural product-based composite (SPI/NaOH/IA-PAE/ Rhizophora spp .) phantoms. The radiological properties of the phantoms were measured at different gamma energies from Compton scatter of photons through angles of 0, 30, 45, 60, 75, and 90 degrees. Ionization chamber (IC) and Gafchromic EBT3 film dosimeters were employed to evaluate the dosimetric characteristics for photons (6-10 MV) and electrons (6-15 MeV). Radiological property results of the composite phantoms were consistent with good quality compared to those of solid water phantoms and theoretical values of water. Photon beam quality index of the SPI15 phantom with p-values of 0.071 and 0.073 exhibited insignificant changes. In addition, good agreement was found between PDD curves measured with IC and Gafchromic EBT3 film for both photons and electrons. The computed therapeutic and half-value depth ranges matched within the limits and are similar to those of water and solid water phantoms. Therefore, the radiological and dosimetric parameters of the studied composite phantom permit its use in the selection of convenient tissue- and water-equivalent phantom material for medical applications.
    Matched MeSH terms: Radiometry/methods
  7. Shakhreet BZ, Bauk S, Tajuddin AA, Shukri A
    Radiat Prot Dosimetry, 2009 Jul;135(1):47-53.
    PMID: 19482883 DOI: 10.1093/rpd/ncp096
    The mass attenuation coefficients (mu/rho) of Rhizophora spp. were determined for photons in the energy range of 15.77-25.27 keV. This was carried out by studying the attenuation of X-ray fluorescent photons from zirconium, molybdenum, palladium, silver, indium and tin targets. The results were compared with theoretical values for average breast tissues in young-age, middle-age and old-age groups calculated using photon cross section database (XCOM), the well-known code for calculating attenuation coefficients and interaction cross-sections. The measured mass attenuation coefficients were found to be very close to the calculated XCOM values in breasts of young-age group.
    Matched MeSH terms: Radiometry/methods*
  8. Lee KH, Kandaiya S
    Appl Radiat Isot, 1996 Mar;47(3):361-3.
    PMID: 8935969
    Matched MeSH terms: Radiometry/methods*
  9. Oresegun A, Tarif ZH, Ghassan L, Zin H, Abdul-Rashid HA, Bradley DA
    Appl Radiat Isot, 2021 Oct;176:109812.
    PMID: 34166948 DOI: 10.1016/j.apradiso.2021.109812
    Investigation has been made of the radioluminescence dose response of Ge-doped silica flat and cylindrical fibers subjected to 6 and 10 MV photon beams. The fibers have been custom fabricated, obtaining Ge dopant concentrations of 6 and 10 mol%, subsequently cut into 20 mm lengths. Each sample has been exposed under a set of similar conditions, with use made of a fixed field size and source to surface distance (SSD). Investigation of dosimetric performance has involved radioluminescence linearity, dose-rate dependence, energy dependence, and reproducibility. Mass for mass, the 6 mol% Ge-doped samples provided the greater radioluminescence yield, with both flat and cylindrical fibers responding linearly to the absorbed dose. Further found has been that the cylindrical fibers provided a yield some 38% greater than that of the flat fibers. At 6 MV, the cylindrical fibers were also found to exhibit repeatability variation of <1%, superior to that of the flat fibers, offering strong potential for use in real-time dosimetry applications.
    Matched MeSH terms: Radiometry/methods*
  10. Al Kafi MA, Arib M, Al Moussa A, Alzorkany F, Shehadeh M, Mohd Yusof MF, et al.
    Appl Radiat Isot, 2023 Feb;192:110576.
    PMID: 36473319 DOI: 10.1016/j.apradiso.2022.110576
    The dosimetry of small fields has become tremendously important with the advent of intensity-modulated radiation therapy (IMRT) and stereotactic radiosurgery, where small field segments or very small fields are used to treat tumors. With high dose gradients in the stereotactic radiosurgery or radiotherapy treatment, small field dosimetry becomes challenging due to the lack of lateral electronic equilibrium in the field, x-ray source occlusion, and detector volume averaging. Small volume and tissue-equivalent detectors are recommended to overcome the challenges. With the lack of a perfect radiation detector, studies on available detectors are ongoing with reasonable disagreement and uncertainties. The joint IAEA and AAPM international code of practice (CoP) for small field dosimetry, TRS 483 (Alfonso et al., 2017) provides guidelines and recommendations for the dosimetry of small static fields in external beam radiotherapy. The CoP provides a methodology for field output factor (FOF) measurements and use of field output correction factors for a series of small field detectors and strongly recommends additional measurements, data collection and verification for CyberKnife (CK) robotic stereotactic radiotherapy/radiosurgery system using the listed detectors and more new detectors so that the FOFs can be implemented clinically. The present investigation is focused on using 3D gel along with some other commercially available detectors for the measurement and verification of field output factors (FOFs) for the small fields available in the CK system. The FOF verification was performed through a comparison with published data and Monte Carlo simulation. The results of this study have proved the suitability of an in-house developed 3D polymer gel dosimeter, several commercially available detectors, and Gafchromic films as a part of small field dosimetric measurements for the CK system.
    Matched MeSH terms: Radiometry/methods
  11. Othman N, Kamarudin SK, Takriff MS, Rosli MI, Engku Chik EM, Adnan MA
    ScientificWorldJournal, 2014;2014:242658.
    PMID: 24741344 DOI: 10.1155/2014/242658
    Radiotracer experiments are carried out in order to determine the mean residence time (MRT) as well as percentage of dead zone, V dead (%), in an integrated mixer consisting of Rushton and pitched blade turbine (PBT). Conventionally, optimization was performed by varying one parameter and others were held constant (OFAT) which lead to enormous number of experiments. Thus, in this study, a 4-factor 3-level Taguchi L9 orthogonal array was introduced to obtain an accurate optimization of mixing efficiency with minimal number of experiments. This paper describes the optimal conditions of four process parameters, namely, impeller speed, impeller clearance, type of impeller, and sampling time, in obtaining MRT and V dead (%) using radiotracer experiments. The optimum conditions for the experiments were 100 rpm impeller speed, 50 mm impeller clearance, Type A mixer, and 900 s sampling time to reach optimization.
    Matched MeSH terms: Radiometry/methods*
  12. Salehi Z, Yusoff AL
    Radiat Prot Dosimetry, 2013;154(3):396-9.
    PMID: 23012482 DOI: 10.1093/rpd/ncs239
    A femur phantom made of wax and a real human bone was used to study the dose during radiographical procedures. The depth dose inside the phantom was determined using DOSXYZnrc, a Monte Carlo simulation software. The results were verified with measurements using TLD-100H. It was found that for 2.5 mm aluminium filtered 84-kVp X-rays, the radiation dose in the bone reached 57 % higher than the surface dose, i.e. 3.23 mGy as opposed to 2.06 mGy at the surface. The use of real bone introduces variations in the bone density in the DOSXYZnrc model, resulting in a lower attenuation effect than expected from solid bone tissues.
    Matched MeSH terms: Radiometry/methods*
  13. Muhammad BG, Jaafar MS, Azhar AR, Akpa TC
    Radiat Prot Dosimetry, 2012 Apr;149(3):340-6.
    PMID: 21642647 DOI: 10.1093/rpd/ncr230
    Measurements of (222)Rn activity concentration were carried out in 39 samples collected from the domestic and drinking water sources used in the island and mainland of Penang, northern peninsular, Malaysia. The measured activity concentrations ranged from 7.49 to 26.25 Bq l(-1), 0.49 to 9.72 Bq l(-1) and 0.58 to 2.54 Bq l(-1) in the raw, treated and bottled water samples collected, respectively. This indicated relatively high radon concentrations compared with that from other parts of the world, which still falls below the WHO recommended treatment level of 100 Bq l(-1). From this data, the age-dependent associated committed effective doses due to the ingestion of (222)Rn as a consequence of direct consumption of drinking water were calculated. The committed effective doses from (222)Rn resulting from 1 y's consumption of these water were estimated to range from 0.003 to 0.048, 0.001 to 0.018 and 0.002 to 0.023 mSv y(-1), for age groups 0-1, 2-16 and >16 y, respectively.
    Matched MeSH terms: Radiometry/methods*
  14. Rodzi M, Zhumadilov K, Ohtaki M, Ivannikov A, Bhattacharjee D, Fukumura A, et al.
    Radiat Environ Biophys, 2011 Aug;50(3):451-8.
    PMID: 21404066 DOI: 10.1007/s00411-011-0358-9
    Background radiation dose is used in dosimetry for estimating occupational doses of radiation workers or determining radiation dose of an individual following accidental exposure. In the present study, the absorbed dose and the background radiation level are determined using the electron spin resonance (ESR) method on tooth samples. The effect of using different tooth surfaces and teeth exposed with single medical X-rays on the absorbed dose are also evaluated. A total of 48 molars of position 6-8 were collected from 13 district hospitals in Peninsular Malaysia. Thirty-six teeth had not been exposed to any excessive radiation, and 12 teeth had been directly exposed to a single X-ray dose during medical treatment prior to extraction. There was no significant effect of tooth surfaces and exposure with single X-rays on the measured absorbed dose of an individual. The mean measured absorbed dose of the population is 34 ± 6.2 mGy, with an average tooth enamel age of 39 years. From the slope of a regression line, the estimated annual background dose for Peninsular Malaysia is 0.6 ± 0.3 mGy y(-1). This value is slightly lower than the yearly background dose for Malaysia, and the radiation background dose is established by ESR tooth measurements on samples from India and Russia.
    Matched MeSH terms: Radiometry/methods*
  15. Mod Ali N
    Radiat Prot Dosimetry, 2011 Mar;144(1-4):90-4.
    PMID: 21147789 DOI: 10.1093/rpd/ncq454
    As a laboratory certified to ISO 9001:2008 and accredited to ISO/IEC 17025, the Secondary Standard Dosimetry Laboratory (SSDL)-Nuclear Malaysia has incorporated an overall comprehensive system for technical and quality management in promoting a reliable individual monitoring service (IMS). Faster identification and resolution of issues regarding dosemeter preparation and issuing of reports, personnel enhancement, improved customer satisfaction and overall efficiency of laboratory activities are all results of the implementation of an effective quality system. Review of these measures and responses to observed trends provide continuous improvement of the system. By having these mechanisms, reliability of the IMS can be assured in the promotion of safe behaviour at all levels of the workforce utilising ionising radiation facilities. Upgradation of in the reporting program through a web-based e-SSDL marks a major improvement in Nuclear Malaysia's IMS reliability on the whole. The system is a vital step in providing a user friendly and effective occupational exposure evaluation program in the country. It provides a higher level of confidence in the results generated for occupational dose monitoring of the IMS, thus, enhances the status of the radiation protection framework of the country.
    Matched MeSH terms: Radiometry/methods
  16. Al-jarrah AM, Abdul Rahman A, Shahrim I, Razak NN, Ababneh B, Tousi ET
    Phys Med, 2016 Jan;32(1):36-41.
    PMID: 26494156 DOI: 10.1016/j.ejmp.2015.09.003
    Genipin gel dosimeters are hydrogels infused with a radiation-sensitive material which yield dosimetric information in three dimensions (3D). The effect of inorganic salts and glucose on the visible absorption dose-response, melting points and mass density of genipin gel dosimeters has been experimentally evaluated using 6-MV LINAC photons. As a result, the addition of glucose with optimum concentration of 10% (w/w) was found to improve the thermal stability of the genipin gel and increase its melting point (Tm) by 6 °C accompanied by a slight decrease of dose-response. Furthermore, glucose helps to adjust the gel mass density to obtain the desired tissue-equivalent properties. A drop of Tm was observed when salts were used as additives. As the salt concentration increased, gel Tm decreased. The mass density and melting point of the genipin gel could be adjusted using different amounts of glucose that improved the genipin gel suitability for 3D dose measurements without introducing additional toxicity to the final gel.
    Matched MeSH terms: Radiometry/methods*
  17. Safari MJ, Wong JH, Ng KH, Jong WL, Cutajar DL, Rosenfeld AB
    Med Phys, 2015 May;42(5):2550-8.
    PMID: 25979047 DOI: 10.1118/1.4918576
    The MOSkin is a MOSFET detector designed especially for skin dose measurements. This detector has been characterized for various factors affecting its response for megavoltage photon beams and has been used for patient dose measurements during radiotherapy procedures. However, the characteristics of this detector in kilovoltage photon beams and low dose ranges have not been studied. The purpose of this study was to characterize the MOSkin detector to determine its suitability for in vivo entrance skin dose measurements during interventional radiology procedures.
    Matched MeSH terms: Radiometry/methods*
  18. Samat SB, Evans CJ, Kadni T, Dolah MT
    Br J Radiol, 2000 Aug;73(872):867-77.
    PMID: 11026863
    A cylindrical gamma-ray 60Co source of activity alpha is predicted to produce an exposure rate X at a distance d in vacuum, given by X = gamma(T)(alpha/d2), where gamma(T) is the specific gamma-ray constant. It has been documented that this formula may be used to approximate X with an accuracy of 1% from a source of length l, provided that d/l > or = 5. It is shown that the formula is accurate to 0.1% under these conditions, provided that the distance is measured from the centre of the source. When absorption in the source and scattering in the collimator are considered, the position of the origin d = 0 can shift by a distance of the order of centimetres. Absorption in air between the source and the ionization chamber adds an exponential factor to the formula. It is shown that even when these modifications are included the discrepancy in the results, although generally less than 1%, is still large compared with the measurement errors. Some suggestions are made for the origin of this discrepancy.
    Matched MeSH terms: Radiometry/methods
  19. Banjade DP, Tajuddin AA, Shukri A
    Appl Radiat Isot, 2001 Aug;55(2):235-43.
    PMID: 11393765
    Protocols developed for high-energy dosimetry IAEA (Technical Reports Series No. 277, 1997), AAPM (Med. Phys. 10 (1983) 741: Med. Phys. 18 (1991) 73: Med. Phys. 21 (1994) 1251), IPEMB (Phys. Med. Biol. 41 (1996) 2557), and HPA (Phys. Med. Biol. 28 (1983) 1097) have continued to enhance precision in dose measurements and the optimization of radiotherapy procedures. While recent dosimetry protocols, including those due to the IAEA and IPEMB, have made a number of improvements compared with previous protocols, it is further desirable to develop absolute dosimetry methods of dose measurements. Measurements based on careful implementation of procedures contained within the various protocols have been carried out in an effort to determine the extent to which discrepancies exist among the protocols. Dose in water at dmax was measured using cylindrical and parallel-plate ionization chambers for 6 MV photon beams and 5 and 12 MeV electron beams. Results obtained from the use of the AAPM and HPA protocols for 6 MV photon beams were found to be 0.9% larger and 0.1% smaller, respectively, than those measured following the IAEA protocol. Calibration dose measurements for 5 and 12 MeV electron beams in water phantoms were found to agree to within 1%, this being well within recommendations from the ICRU and other sources regarding the accuracy of dose delivery.
    Matched MeSH terms: Radiometry/methods*
  20. Samat SB, Evans CJ
    Radiat Prot Dosimetry, 2003;103(4):341-7.
    PMID: 12797557
    For the specific absorbed dose constant for 60Co photons, three values quoted directly in the literature and two derived indirectly from published information are reported. The three publications giving the direct values mentioned no medium of absorption, whereas the other two specify tissue. A database of the specific absorbed dose constant is generated for each of 14 media namely air, water, bone and 11 types of soft tissue. These values are consistent with the three directly quoted values plus one of the indirectly obtained values. Air is found to be unlikely as the medium for the first three; and appropriate media for these are suggested. For the other two values, the generated database suggests that one is too small to be accurate; while the other is correct for tissue (as stated in the publication). An apparent error of 10(3) is identified in one of the values directly quoted.
    Matched MeSH terms: Radiometry/methods*
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