MyMedR

Fulltext Adenoid Cystic Carcinoma of the Nasopharynx: A Case Series

Ng BHK, Tang IP

Indian J Otolaryngol Head Neck Surg, 2019 Oct;71(Suppl 1):731-733.

PMID: 31742052 DOI: 10.1007/s12070-018-1523-0

Adenoid cystic carcinomas are tumors that are more commonly seen in the salivary glands than in the nasopharynx. Nasopharyngeal adenoid cystic carcinomas are rare and cases that are reported in the literatures are few. Treatment is mainly by surgical resection. Here, we report 2 cases of nasopharyngeal adenoid cystic carcinoma.

Matched MeSH terms: Salivary Glands

The distinctive features of the tumours of the salivary glands in Malaya

MARSDEN AT

Br. J. Cancer, 1951 Dec;5(4):375-81.

PMID: 14904833

Matched MeSH terms: Salivary Gland Neoplasms*; Salivary Glands*

Fulltext Transient unilateral pneumoparotid following upper endoscopy

Pillay Y, Goh KL

JUMMEC, 2014;17(2):12-13.

MyJurnal

Salivary gland swelling is a rare complication of upper endoscopy with less than twelve cases reported in the literature. The swelling is usually transient in nature, with complete resolution in a few hours .While all the major paired salivary glands have been implicated, the exact aetiology remains obscure. In this case report, a sixty one year old female presents with unilateral swelling of the right parotid gland immediately following an upper endoscopy. There was complete resolution of the pneumoparotid with no neurological sequelae.

Matched MeSH terms: Salivary Glands

Fulltext Giant Submandibular Calculus Eroding Oral Cavity Mucosa

Lim EH, Nadarajah S, Mohamad I

Oman Med J, 2017 Sep;32(5):432-435.

PMID: 29026477 DOI: 10.5001/omj.2017.81

Sialolithiasis is the formation of calculi or sialoliths in the salivary gland. It is the most common benign condition of the salivary gland. Sialolithiasis can occur in all salivary glands. The submandibular gland is most commonly affected followed by the parotid gland. Calculi commonly measure less than 10 mm. Calculi of more than 15 mm are termed giant salivary gland calculi and are infrequently reported in the literature. Here, we report a case of unusually large submandibular gland calculus of 5 cm in greatest dimension which caused erosion of the oral cavity.

Matched MeSH terms: Salivary Glands

Partial superficial parotidectomy for pleomorphic adenoma of the parotid gland

Bhattacharya A, Singh M, Shah A, Varghese LL

BMJ Case Rep, 2021 Jun 14;14(6).

PMID: 34127499 DOI: 10.1136/bcr-2020-238759

Pleomorphic adenoma, otherwise called as benign mixed tumour, is the most common salivary gland tumour which accounts for 60% of all benign salivary gland tumours. The clinical, radiological and histopathological presentations are varied. The tumour occurs in diverse anatomical sites and can consist of epithelial and mesenchymal components. In this case report, the patient reported with an asymptomatic swelling on the face. CT scan with contrast was advised. The clinical, roentgenographic findings and Fine Needle Aspiration Cytology were indicative of pleomorphic adenoma of the parotid gland. Treatment included partial superficial parotidectomy under general anaesthesia using the modified Blair's incision. The facial nerve was not involved. Part of the gland along with the tumour was resected completely superficial to the facial nerve with a margin of normal tissue all around. Histopathologic examination of tissue specimen confirmed the lesion as pleomorphic adenoma. The patient was asymptomatic at 6-month follow-up.

Matched MeSH terms: Salivary Glands

Hyalinizing clear cell carcinoma of minor salivary gland: case report

Manoharan M, Othman NH, Samsudin AR

Braz Dent J, 2002;13(1):66-9.

PMID: 11870967

Hyalinizing clear cell carcinoma is a low-grade neoplasm of the minor salivary gland composed exclusively of epithelial cells and not myoepithelial cells. It predominantly affects the oral cavity of adult females. It is microscopically characterized by hyalinizing stroma and clear cells, which are typically positive for cytokeratin markers and negative for S 100 and smooth muscle actin (SMA). Cystic degeneration can also be present. Pathologists should be aware of this new entity so as not to misdiagnose otherwise. To our knowledge, this is the first case report of its kind from Malaysia.

Matched MeSH terms: Salivary Glands, Minor/pathology*

Fulltext Xerostomia and COVID-19: Unleashing Pandora's Box

Saniasiaya J

Ear Nose Throat J, 2021 Apr;100(2_suppl):139S.

PMID: 32955342 DOI: 10.1177/0145561320960353

Matched MeSH terms: Salivary Glands/metabolism

Fulltext De novo transcriptome analysis shows differential expression of genes in salivary glands of edible bird's nest producing swiftlets

Looi QH, Amin H, Aini I, Zuki M, Omar AR

BMC Genomics, 2017 07 03;18(1):504.

PMID: 28673247 DOI: 10.1186/s12864-017-3861-9

BACKGROUND: Edible bird's nest (EBN), produced from solidified saliva secretions of specific swiftlet species during the breeding season, is one of the most valuable animal by-products in the world. The composition and medicinal benefits of EBN have been extensively studied, however, genomic and transcriptomic studies of the salivary glands of these birds have not been conducted.

RESULTS: The study described the transcriptomes of salivary glands from three swiftlet species (28 samples) generated by RNASeq. A total of 14,835 annotated genes and 428 unmapped genes were cataloged. The current study investigated the genes and pathways that are associated with the development of salivary gland and EBN composition. Differential expression and pathway enrichment analysis indicated that the expression of CREB3L2 and several signaling pathways involved in salivary gland development, namely, the EGFR, BMP, and MAPK signaling pathways, were up-regulated in swiftlets producing white EBN (Aerodramus fuciphagus) and black EBN (Aerodramus maximus) compared with non-EBN-producing swiftlets (Apus affinis). Furthermore, MGAT, an essential gene for the biosynthesis of N-acetylneuraminic acid (sialic acid), was highly expressed in both white- and black-nest swiftlets compared to non-EBN-producing swiftlets. Interspecies comparison between Aerodramus fuciphagus and Aerodramus maximus indicated that the genes involved in N-acetylneuraminic and fatty acid synthesis were up-regulated in Aerodramus fuciphagus, while alanine and aspartate synthesis pathways were up-regulated in Aerodramus maximus. Furthermore, gender-based analysis revealed that N-glycan trimming pathway was significantly up-regulated in male Aerodramus fuciphagus from its natural habitat (cave) compared to their female counterpart.

CONCLUSIONS: Transcriptomic analysis of salivary glands of different swiftlet species reveal differential expressions of candidate genes that are involved in salivary gland development and in the biosynthesis of various bioactive compounds found in EBN.

Matched MeSH terms: Salivary Glands/metabolism*

Fulltext Unusual Presentation of Primary Squamous Cell Carcinoma of Mandible

Shanmugasundaram K, Subramanian S, Vedam V, Kumar V

Case Rep Pathol, 2016;2016:9154309.

PMID: 28078158 DOI: 10.1155/2016/9154309

Carcinoma arising primarily from the jaw is a locally aggressive lesion with poor prognosis. Primary intraosseous carcinoma (PIOC) lesion develops either de novo remnants of odontogenic epithelium, odontogenic cyst/tumor, epithelium remnants, or/and salivary gland residues. We describe very interesting case of primary intraosseous carcinoma of mandible. This extensive lesion was sent for oncological opinion and further management. Due to the uncertainty of diagnostic criteria of PIOC, only few cases of this lesion with a typical presentation have been reported. This article presents a case of primary intraosseous carcinoma with a unique appearance and detailed review stating its clinicopathological correlation.

Matched MeSH terms: Salivary Glands

Fulltext Stingless Bee-Collected Pollen (Bee Bread): Chemical and Microbiology Properties and Health Benefits

Mohammad SM, Mahmud-Ab-Rashid NK, Zawawi N

Molecules, 2021 Feb 11;26(4).

PMID: 33670262 DOI: 10.3390/molecules26040957

Stingless bee-collected pollen (bee bread) is a mixture of bee pollen, bee salivary enzymes, and regurgitated honey, fermented by indigenous microbes during storage in the cerumen pot. Current literature data for bee bread is overshadowed by bee pollen, particularly of honeybee Apis. In regions such as South America, Australia, and Southeast Asia, information on stingless bee bee bread is mainly sought to promote the meliponiculture industry for socioeconomic development. This review aims to highlight the physicochemical properties and health benefits of bee bread from the stingless bee. In addition, it describes the current progress on identification of beneficial microbes associated with bee bread and its relation to the bee gut. This review provides the basis for promoting research on stingless bee bee bread, its nutrients, and microbes for application in the food and pharmaceutical industries.

Matched MeSH terms: Salivary Glands/metabolism; Salivary Glands/chemistry*

Evaluation of irradiated salivary gland function in patients with head and neck tumours treated with radiotherapy

Baharudin A, Khairuddin A, Nizam A, Samsuddin AR

J Laryngol Otol, 2009 Jan;123(1):108-13.

PMID: 18452635 DOI: 10.1017/S0022215108002466

Radiotherapy is an important treatment modality for head and neck tumours. One of its major drawbacks is post-treatment salivary gland hypofunction. This study was performed to objectively evaluate the salivary gland function in post-irradiated head and neck tumour patients.

Matched MeSH terms: Salivary Glands/radiation effects*; Salivary Glands/secretion

Ulcerated bleeding palisaded encapsulated neuroma of the tongue

Dhanuka S, Rodrigues G, Carnello S

Malays J Pathol, 2019 Aug;41(2):229-232.

PMID: 31427561

INTRODUCTION: Palisaded encapsulated neuroma (PEN) is a benign lesion of Schwann cells and its occurrence in the oral mucosa especially the tongue is very rare.

CASE REPORT: This article describes a case of a 41-year-old male, a chronic smoker with an actively bleeding, ulcerated, solitary, firm lesion on the lateral border of the tongue which had bled thrice before. A differential diagnosis of pyogenic granuloma, haemangioma, fibroma, nerve sheath tumour, salivary gland tumour and malignancy was made and surgically excised. Histopathology of the excised specimen revealed a well-circumscribed lesion with spindle-shaped cells arranged in interlacing fascicles and with the help of immunohistochemical markers confirmed it to be a PEN.

DISCUSSION: To our knowledge, this is the first description of an ulcerated PEN presented with an active bleed.

Matched MeSH terms: Salivary Glands

Fulltext Preliminary Study On Saliva From Diabetic And Non-Diabetic Individuals By Polyacrylamide Gel Electrophoresis

Hoe, S.Z., Pendek, R., Lam, S.K., Rahim, Z.H.A.

Ann Dent, 1997;4(1):-.

MyJurnal

Human saliva contains a large number of proteins which can be separated using polyacrylamide gel electrophoresis (PAGE). In this study the protein profiles of whole saliva of diabetic and non-diabetic were compared. Considerable variations between individuals in the protein profiles were observed. The saliva from diabetic patients appeared to have more of proline-rich protein bands in the molecular weight region below 56 KOa. Further investigations using individual gland saliva should be carried out.

Matched MeSH terms: Salivary Glands

Fulltext Adenoid cystic carcinoma – a case report and review of literature

Kanneppady, Sham Kishor, Sakri, Santosh B., Chatra, Laxmikanth, Prashanth, Shenoy K.

Malaysian Dental Journal, 2010;31(2):79-83.

MyJurnal

Adenoid cystic carcinoma (ACC) is a rare malignant tumor that arises within secretary glands, most commonly the major and minor salivary glands. It has a tendency for a prolonged clinical course, perineural invasion, with local recurrences and distant metastases. The three recognized histopathologic pattern of ACC are cribriform, tubular, and solid with the cribriform being most common. Standard treatment for salivary gland ACC is surgery and postoperative radiotherapy. We report a case of ACC of palate in a 30-year-old female and review the literature.

Matched MeSH terms: Salivary Glands, Minor

Fulltext A retrospective clinico-statistical analysis of lip mucoceles occurrence in children below 16 years seen at a government hospital based paediatric dental clinic

Sockalingam, G.

Malaysian Dental Journal, 2007;28(1):41-44.

MyJurnal

The objective of this study is to report the occurrence, demographic and clinical findings of lip mucoceles in children. A restrospective study was conducted at the paediatric dental clinic situated at Hospital Sultanah Aminah, Johor Bahru. The period of study was 3 years beginning 2003 to 2005. Out of 1407 new cases seen over the period of study 17 (1.2%) patients presented with lip mucoceles. All lesions occurred in the lower lip. There was no sex or racial predilection. The average duration of the lesion prior to seeking treatment was 2.8 ± 2.8 months. Most patients (76.5%) first saw a medical practitioner for the problem. No spontaneous resolution of the lesions in any of the patients was noted. The preferred method of treatment of lower lip mucoceles in children is surgical excision of the involved minor salivary glands. Salivary gland mucoceles in children predominantly involve the lower lip and can be treated successfully by complete removal of the involved and associated minor salivary glands.

Matched MeSH terms: Salivary Glands, Minor

Fulltext The effect of beverages on the release of calcium from the enamel surface

Fathilah, A.R., Rahim, Z.H.A.

Ann Dent, 2008;15(1):1-4.

MyJurnal

In this study, the effect of beverages (Coke TM, Sprite™, Ribena™, Chrysanthemum tea and mineral water) on the demineralisation of the enamel surface was investigated. Demineralisation was determined by the rate of calcium released from the enamel surface on exposure to the beverages. Calcium was determined using the EDTA titration method. The pH of these beverages was measured using a pH meter and found to be in the acidic range (2.43 to 5.79) while mineral water which served as a control has a pH of 7.00. Ii was found that the rate of calcium released from Coke™(0.76 J..lg/min) showed a significant mean difference from Sprite™ (0.38 J..lg/min), Chrysanthemum tea (0.10 J..lg/min) and mineral water (0.00 J..lg/min)at p< .05, but was however not significantly different from Ribena™. Likewise, Chrysanthemum tea and mineral water also showed statistically no significant mean difference in the released of calcium during the study period. The results obtained in this study indicated that beverages with low pH may pose detrimental effect on the enamel surface which could have clinical implication, especially in people with salivary gland dysfunction or low salivary flow.

Matched MeSH terms: Salivary Glands

Fulltext Management of a Rare Lymphoepithelial Carcinoma of the Submandibular Gland in Elderly

Sairin ME, Yahya N, Kuan CY, Yunus MRM, Abdullah MK

Indian J Otolaryngol Head Neck Surg, 2019 Oct;71(Suppl 1):18-20.

PMID: 31741921 DOI: 10.1007/s12070-015-0940-6

Lymphoepithelial carcinoma (LEC) of salivary glands is a rare malignant salivary gland tumour and demonstrates genetic and regional distribution. It commonly occurs in major salivary gland especially parotid gland. We report a case of LEC of submandibular gland occurring in a 70 year-old lady.

Matched MeSH terms: Salivary Glands

Evaluation of fine needle aspiration cytology of salivary glands: an analysis of 141 cases

Jayaram G, Dashini M

Malays J Pathol, 2001 Dec;23(2):93-100.

PMID: 12166598

141 salivary gland lesions that were subjected to fine needle aspiration (FNA) cytology at the University Hospital, Kuala Lumpur, from January 1993 to October 2000 were reviewed with a view to assess the sensitivity and utility of cytological diagnosis in diseases of salivary glands. The highest number of cases was seen in the sixth decade of life. There was no gender preponderance in salivary gland neoplasms except in Warthin's tumours that occurred predominantly in males. The parotid gland was the most frequent salivary gland needled. Seven cases (5%) presented with bilateral salivary gland enlargement. Cytological study yielded a neoplastic diagnosis in 74.5% cases. Of the neoplastic lesions, 71.4% could be definitely designated as benign and 25.7% as clearly malignant. Pleomorphic adenoma and acinic cell carcinoma were the most common benign and malignant neoplasms diagnosed respectively. 53 cases had histological correlation; of these, 49 (92.5%) were neoplastic. The overall diagnostic accuracy of FNA cytological diagnosis in salivary gland lesions was found to be 73.6%.

Matched MeSH terms: Salivary Glands/pathology*

Glycogen-rich clear cell carcinoma in the tongue

Rajab E, Akmal SN, Nasir AM

J Laryngol Otol, 1994 Aug;108(8):716-8.

PMID: 7930932

The case of a minor salivary gland tumour, arising from the tongue, with nodal metastasis is presented. Biopsy of the tumour and fine-needle aspiration cytology of the neck swelling showed the presence of a clear cell carcinoma with evidence of nodal metastases. A commando operation was performed and the defect was reconstructed using a local tongue flap. The literature review indicated that the neoplasm was rare and its site of occurrence rather unusual.

Matched MeSH terms: Salivary Glands, Minor/pathology

Fulltext Salivary Amylase as a Marker of Salivary Gland Function in Patients Undergoing Radiotherapy for Oral Cancer

Vedam VKV, Boaz K, Natarajan S, Ganapathy S

J Clin Lab Anal, 2017 May;31(3).

PMID: 27637993 DOI: 10.1002/jcla.22048

BACKGROUND: The aim of this study was to evaluate salivary amylase in patients with primary oral cancer undergoing radiotherapy as the main modality of treatment.

MATERIALS/METHODS: The study was conducted on ten histologically proven cases of oral cancer undergoing radiotherapy. Stimulated whole saliva was collected at three stages of radiotherapy-0, 3, and 6 weeks. Salivary amylase was estimated using Henry-Chiamori method and comparison was made with appropriate age- and gender-matched controls.

RESULTS: Salivary amylase levels showed significant decrease in healthy subjects when compared to oral cancer patients (P < 0.001). The latter group also showed changing trend with initial decrease from 0 to 3 weeks followed by increase from 3 to 6 weeks following radiotherapy (P < 0.0528).

CONCLUSIONS: The trend in changes in the levels of salivary amylase could be used as a surrogate marker of salivary gland function in patients with oral cancer undergoing radiotherapy as primary treatment.

Matched MeSH terms: Salivary Glands/metabolism*

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