Displaying publications 1 - 20 of 106 in total

  1. Ibrahim N
    Bull Environ Contam Toxicol, 1993 Aug;51(2):199-202.
    PMID: 8353382
    Matched MeSH terms: Trace Elements/analysis*
  2. Harun HH, Kasim MRM, Nurhidayu S, Ash'aari ZH, Kusin FM, Karim MKA
    PMID: 33923119 DOI: 10.3390/ijerph18094562
    The aim of this study was to propose a groundwater quality index (GWQI) that presents water quality data as a single number and represents the water quality level. The development of the GWQI in agricultural areas is vital as the groundwater considered as an alternative water source for domestic purposes. The insufficiency of the groundwater quality standard in Malaysia revealed the importance of the GWQI development in determining the quality of groundwater. Groundwater samples were collected from thirteen groundwater wells in the Northern Kuala Langat and the Southern Kuala Langat regions from February 2018 to January 2019. Thirty-four parameters that embodied physicochemical characteristics, aggregate indicator, major ions, and trace elements were considered in the development of the GWQI. Multivariate analysis has been used to finalize the important parameters by using principal component analysis (PCA). Notably, seven parameters-electrical conductivity, chemical oxygen demand (COD), magnesium, calcium, potassium, sodium, and chloride were chosen to evaluate the quality of groundwater. The GWQI was then verified by comparing the groundwater quality in Kota Bharu, Kelantan. A sensitivity analysis was performed on this index to verify its reliability. The sensitivity GWQI has been analyzed and showed high sensitivity to any changes of the pollutant parameters. The development of GWQI should be beneficial to the public, practitioners, and industries. From another angle, this index can help to detect any form of pollution which ultimately could be minimized by controlling the sources of pollutants.
    Matched MeSH terms: Trace Elements*
  3. Shazia Q, Mohammad ZH, Rahman T, Shekhar HU
    Anemia, 2012;2012:270923.
    PMID: 22645668 DOI: 10.1155/2012/270923
    Beta thalassemia major is an inherited disease resulting from reduction or total lack of beta globin chains. Patients with this disease need repeated blood transfusion for survival. This may cause oxidative stress and tissue injury due to iron overload, altered antioxidant enzymes, and other essential trace element levels. The aim of this review is to scrutinize the relationship between oxidative stress and serum trace elements, degree of damage caused by oxidative stress, and the role of antioxidant enzymes in beta thalassemia major patients. The findings indicate that oxidative stress in patients with beta thalassemia major is mainly caused by tissue injury due to over production of free radical by secondary iron overload, alteration in serum trace elements and antioxidant enzymes level. The role of trace elements like selenium, copper, iron, and zinc in beta thalassemia major patients reveals a significant change of these trace elements. Studies published on the status of antioxidant enzymes like catalase, superoxide dismutase, glutathione, and glutathione S-transferase in beta thalassemia patients also showed variable results. The administration of selective antioxidants along with essential trace elements and minerals to reduce the extent of oxidative damage and related complications in beta thalassemia major still need further evaluation.
    Matched MeSH terms: Trace Elements*
  4. Khan N, Choi JY, Nho EY, Jamila N, Habte G, Hong JH, et al.
    Food Chem, 2014 Sep 1;158:200-6.
    PMID: 24731332 DOI: 10.1016/j.foodchem.2014.02.103
    This study aimed at analyzing the concentrations of 23 minor and trace elements in aromatic spices by inductively coupled plasma-mass spectrometry (ICP-MS), after wet digestion by microwave system. The analytical method was validated by linearity, detection limits, precision, accuracy and recovery experiments, obtaining satisfactory values in all cases. Results indicated the presence of variable amounts of both minor and trace elements in the selected aromatic spices. Manganese was high in cinnamon (879.8 μg/g) followed by cardamom (758.1 μg/g) and clove (649.9 μg/g), strontium and zinc were high in ajwain (489.9 μg/g and 84.95 μg/g, respectively), while copper was high in mango powder (77.68 μg/g). On the whole some of the minor and essential trace elements were found to have good nutritional contribution in accordance to RDA. The levels of toxic trace elements, including As, Cd, and Pb were very low and did not found to pose any threat to consumers.
    Matched MeSH terms: Trace Elements/analysis; Trace Elements/chemistry*
  5. Qamar Z, Haji Abdul Rahim ZB, Chew HP, Fatima T
    J Pak Med Assoc, 2017 Jan;67(1):116-120.
    PMID: 28065967
    Dental enamel, an avascular, irreparable, outermost and protective layer of the human clinical crown has a potential to withstand the physico-chemical effects and forces. These properties are being regulated by a unique association among elements occurring in the crystallites setup of human dental enamel. Calcium and phosphate are the major components (hydroxyapatite) in addition to some trace elements which have a profound effect on enamel. The current review was planned to determine the aptitude of various trace elements to substitute and their influence on human dental enamel in terms of physical and chemical properties.
    Matched MeSH terms: Trace Elements/analysis; Trace Elements/chemistry
  6. Prabakaran K, Nagarajan R, Eswaramoorthi S, Anandkumar A, Franco FM
    Chemosphere, 2019 Mar;219:933-953.
    PMID: 30572242 DOI: 10.1016/j.chemosphere.2018.11.158
    The geochemistry and distribution of major, trace and rare earth elements (REE's) was studied in the surface sediments of the Lower Baram River during two seasons: the Monsoon (MON) and Post - monsoon (POM). The major geochemical processes controlling the distribution and mobility of major, trace and REE's in the Lower Baram River surface sediments was revealed through factor analysis. The risk assessment of major and trace element levels was studied at three specific levels; i.e. the enrichment level [Contamination Factor (Cf), with the geo-accumulation index (Igeo)], the availability level [metals bound to different fractions, risk assessment code (RAC)], and the biological toxicity level [effect range low (ERL) and effect range medium (ERM)]. The results of all the indices indicate that Cu is the element of concern in the Lower Baram River sediments. The geochemical fractionation of major and trace elements were studied through sequential extraction and the results indicated a higher concentration of Mn in the exchangeable fraction. The element of concern, Cu, was found to be highly associated in the organic bound (F4) fraction during both seasons and a change in the redox, possibly due to storms or dredging activities may stimulate the release of Cu into the overlying waters of the Lower Baram River.
    Matched MeSH terms: Trace Elements/chemistry*
  7. Krishnankutty N, Idris M, Hamzah FM, Manan Y
    Environ Sci Pollut Res Int, 2019 Aug;26(24):25046-25056.
    PMID: 31250391 DOI: 10.1007/s11356-019-05680-3
    Bauxite and iron ore mining is the major contributor to metal pollution in Tasik Chini, Malaysia. Deforestation of the protected zone of reserve forest exacerbates the problem. The current study is to understand the speciation of metals spatially in sediment to analyse the risk associated in terms of its mobility and bioavailability. The samples of sediment are collected from Sungai Jemberau, Laut Jemberau, and Laut Gumum of Tasik Chini. Four samplings were conducted for a year, by collecting the surface sediment. Sequential extraction method was followed for speciation of sediment and classified it into exchangeable, reducible, Fe-Mn oxides, organic and residual fractions. The results were also analyzed using principal component analysis (PCA) and cluster analysis (CA). The result reveals that Fe, Al, Mn, Zn, and Pb are the primary constituents of sediment contributing to about 98% of residual fraction. Co, Cd, Cr, As, and Ni are found in trace metal concentration and are identified to be mainly released from anthropogenic sources nearby. Although the individual proportion is less than major metals in exchangeable and carbonate fraction, they possess geochemically significant concentration above the permissible limit. More than 70-80% of all its total concentration proportion is hence found in mobile and bioavailable state. These possess toxic and have chronic effects to aquatic life and public health even in trace elemental concentration. Hence, these metals are the most toxic and bioavailable metals pausing risk for aquatic and public health. PCA analysis highlights that the enrichment of heavy metals in bioavailable fraction is mostly contributed from anthropogenic sources. The same results are emphasized by cluster analysis.
    Matched MeSH terms: Trace Elements/analysis*
  8. Ariano A, Musco N, Severino L, De Maio A, Tramice A, Tommonaro G, et al.
    Biomolecules, 2021 05 29;11(6).
    PMID: 34072325 DOI: 10.3390/biom11060804
    The use of seaweeds as additives in animal nutrition may be a valid option to traditional feed as they represent a rich source of minerals, carbohydrates and antioxidants. The aim of this study was to analyze the chemical composition and in vitro antioxidant capacity of two tropical eucheumatoids, Kappaphycus alvarezii and Kappaphycus striatus, in Malaysian wild offshore waters. The chemical analysis was performed via inductively coupled plasma-optical emission spectroscopy for evaluating the concentration of toxic (Cd, Pb, Hg, As) and essential elements (Mn, Fe, Cu, Ni, Zn, Se); NMR spectroscopy was used for carrageenans investigation. Furthermore, the soluble and fat-soluble antioxidant capacities were determined by FRAP, DPPH and ABTS assays. The chemical analysis revealed a higher content of trace elements in K. alvarezii as compared to K. striatus, and both exhibited a high mineral content. No significant differences in metal concentrations were found between the two species. Both samples showed a mixture of prevailing κ- and t-carrageenans. Finally, the levels of soluble and fat-soluble antioxidants in K. alvarezii were significantly higher than in K. striatus. Our findings suggest that K. alvarezii could be used as a potential feed additive because of its favorable chemical and nutritional features.
    Matched MeSH terms: Trace Elements/analysis*
  9. M. Jayaprakash, R. Nagarajan, P. M. Velmurugan, L. Giridharan, girilogu@yahoo.com, B. Urban
    The composite nature of Ennore Creek, receiving polluted waters from Buckingham canal, River Kortalaiyar, and the presence of numerous industries rapidly degrade the coastal environment. In this study, multivariate statistical technique was used to assess the nature of pollution and to identify the factors responsible for the enrichment of trace metals in the creek sediments. Forty samples were collected during pre- and post-monsoon periods to evaluate the seasonal variations on the concentration of trace metals in the sediments. The results indicate that not much seasonal variation exists in the concentration of trace metals in the sediments of Ennore creek. Results of the cluster analysis illustrate that the enrichment of trace metals was mainly from anthropogenic sources. Meanwhile, correlation coefficient among the metals reveals that some of the metals (Fe and Al) derived were of natural origin. The complex data matrix of the sediment were interpreted after reduction to three factors and the results illustrate the extent of the influence of anthropogenic activities. The spatial distribution diagrams demonstrate and demarcate the region of enrichment of metals in the sediments of Ennore creek.
    Matched MeSH terms: Trace Elements
  10. Lim KK, Siti Rohana D, Zawiah A, Wan Nazaimoon WM
    Trop Biomed, 2006 Dec;23(2):172-8.
    PMID: 17322819 MyJurnal
    This is a cross-sectional study conducted from January to September 2004 in a group of school children aged 8 -10 years old. The schools and study subjects were selected using stratified systematic sampling technique. A total of 44 schools and 1100 subjects were selected from schools with iodinator and schools without iodinator. Samples collected were spot urine and drinking water. Dietary and iodised water consumption data were obtained from interviews. A total of 931 subjects (84.6%) responded; 558 (50.7%) from schools with iodinator and 373 (33.9%) from schools without iodinator. Results showed that in more than half (53.8%) of the schools with iodinators, mean water iodine level was below 25 microg/L. The study population in Terengganu was found to be mildly iodine deficient with an overall median urine iodine concentration (uIC) of 74 microg/L. Based on WHO criteria, 4.1% with uIC <20 microg/L (severe), 19.5% with uIC between 20-49 microg/L (moderate), 49.2% with uIC between 50-99 microg/L (mild) and 27.2% was iodine sufficient with uIC >100 microg/L. Majority of the study subjects were found to have high seafood intake (> 90%) and low in goitrogen food intake. This study suggests water iodinator system may not be a suitable method of supplying iodine and an alternative is needed in order to eradicate the iodine deficiency problem seen in some parts of Malaysia.
    Matched MeSH terms: Trace Elements/administration & dosage*; Trace Elements/deficiency*; Trace Elements/chemistry
  11. Moniruzzaman M, Chowdhury MA, Rahman MA, Sulaiman SA, Gan SH
    Biomed Res Int, 2014;2014:359890.
    PMID: 24982869 DOI: 10.1155/2014/359890
    The present study was undertaken to determine the content of six minerals, five trace elements, and ten pesticide residues in honeys originating from different regions of Malaysia. Calcium (Ca), magnesium (Mg), iron (Fe), and zinc (Zn) were analyzed by flame atomic absorption spectrometry (FAAS), while sodium (Na) and potassium (K) were analyzed by flame emission spectrometry (FAES). Trace elements such as arsenic (As), lead (Pb), cadmium (Cd), copper (Cu), and cobalt (Co) were analyzed by graphite furnace atomic absorption spectrometry (GFAAS) following the microwave digestion of honey. High mineral contents were observed in the investigated honeys with K, Na, Ca, and Fe being the most abundant elements (mean concentrations of 1349.34, 236.80, 183.67, and 162.31 mg/kg, resp.). The concentrations of the trace elements were within the recommended limits, indicating that the honeys were of good quality. Principal component analysis reveals good discrimination between the different honey samples. The pesticide analysis for the presence of organophosphorus and carbamates was performed by high performance liquid chromatography (HPLC). No pesticide residues were detected in any of the investigated honey samples, indicating that the honeys were pure. Our study reveals that Malaysian honeys are rich sources of minerals with trace elements present within permissible limits and that they are free from pesticide contamination.
    Matched MeSH terms: Trace Elements/analysis*
  12. Chua LS, Abdul-Rahman N, Rosidi B, Lee CT
    Nat Prod Res, 2013 Mar;27(4-5):314-8.
    PMID: 22468741 DOI: 10.1080/14786419.2012.676552
    A water extraction method has been used to extract plant proteins from the roots of Eurycoma longifolia harvested from Perak and Pahang, Malaysia. On the basis of the spectroscopic Bradford assay, Tongkat Ali Perak and Pahang contained 0.3868 and 0.9573 mg mL(-1) of crude protein, respectively. The crude proteins were separated by one dimensional 15% sodium dodecyl sulphate polyacrylamide gel electrophoresis into two (49.8 and 5.5 kD) and four (49.8, 24.7, 21.1 and 5.5 kD) protein spots for Tongkat Ali Perak and Pahang, respectively. Isoleucine was present in the highest concentration significantly. Both plant samples showed differences in the mineral and trace element profiles, but the minerals calcium, magnesium and potassium were present in the highest concentration. The highly concerned toxic metals such as arsenic and lead were not detected.
    Matched MeSH terms: Trace Elements/analysis*
  13. Prakash A, Dhaliwal GK, Kumar P, Majeed AB
    Int J Neurosci, 2017 Feb;127(2):99-108.
    PMID: 27044501
    Alzheimer's disease (AD) is the most common form of dementia. Several hypotheses have been put forward to explain the basis of disease onset and progression. A complicated array of molecular events has been implicated in the pathogenesis of AD. It is attributed to a variety of pathological conditions that share similar critical processes, such as oxidative stress, proteinaceous aggregations, mitochondrial dysfunctions and energy failure. There is increasing evidence suggesting that metal homeostasis is dysregulated in the pathology of AD. Biometals play an important role in the normal body functioning but AD may be mediated or triggered by disproportion of metal ions leading to changes in critical biological systems and initiating a cascade of events finally leading to neurodegeneration and cell death. The link is multifactorial, and although the source of the shift in oxidative homeostasis is still unclear, current evidence points to changes in the balance of redox transition metals, especially iron, copper (Cu) and other trace metals. Their levels in the brain are found to be elevated in AD. In other neurodegenerative disorders, Cu, zinc, aluminum and manganese are involved. This paper is a review of recent advances of the role of metals in the pathogenesis and pathophysiology of AD and related neurodegenerative diseases.
    Matched MeSH terms: Trace Elements/metabolism*
  14. Fry B, Carter JF, Tinggi U, Arman A, Kamal M, Metian M, et al.
    Isotopes Environ Health Stud, 2016 Dec;52(6):619-32.
    PMID: 26982881 DOI: 10.1080/10256016.2016.1149481
    To assess coastal ecosystem status and pollution baselines, prawns were collected from the commercial catches of eight Asia-Pacific countries (Australia, Bangladesh, Indonesia, Myanmar, Philippines, Pakistan, Sri Lanka and Thailand). Samples collected from 21 sites along regional coastlines were analysed for trace metal and stable isotopic compositions of H, C, N, O and S. A combination of simple averaging and multivariate analyses was used to evaluate the data. Sites could be assigned to easily recognise polluted and unpolluted groups based on the prawn results. Some filter-feeding clams were also collected and analysed together with the benthic-feeding prawns, and the prawns generally had lower trace metal burdens. Climate change effects were not strongly evident at this time, but altered ocean circulation and watershed run-off patterns accompanying future climate change are expected to change chemical patterns recorded by prawns along these and other coastlines. Stable isotopes, especially (15)N, can help to distinguish between relatively polluted and unpolluted sites.
    Matched MeSH terms: Trace Elements/analysis*
  15. Latif MT, Ngah SA, Dominick D, Razak IS, Guo X, Srithawirat T, et al.
    J Environ Sci (China), 2015 Jul 1;33:143-55.
    PMID: 26141887 DOI: 10.1016/j.jes.2015.02.002
    The aim of this study was to determine the source apportionment of dust fall around Lake Chini, Malaysia. Samples were collected monthly between December 2012 and March 2013 at seven sampling stations located around Lake Chini. The samples were filtered to separate the dissolved and undissolved solids. The ionic compositions (NO3-, SO4(2-), Cl- and NH4+) were determined using ion chromatography (IC) while major elements (K, Na, Ca and Mg) and trace metals (Zn, Fe, Al, Ni, Mn, Cr, Pb and Cd) were determined using inductively coupled plasma mass spectrometry (ICP-MS). The results showed that the average concentration of total solids around Lake Chini was 93.49±16.16 mg/(m2·day). SO4(2-), Na and Zn dominated the dissolved portion of the dust fall. The enrichment factors (EF) revealed that the source of the trace metals and major elements in the rain water was anthropogenic, except for Fe. Hierarchical agglomerative cluster analysis (HACA) classified the seven monitoring stations and 16 variables into five groups and three groups respectively. A coupled receptor model, principal component analysis multiple linear regression (PCA-MLR), revealed that the sources of dust fall in Lake Chini were dominated by agricultural and biomass burning (42%), followed by the earth's crust (28%), sea spray (16%) and a mixture of soil dust and vehicle emissions (14%).
    Matched MeSH terms: Trace Elements/chemistry
  16. Ng KH, Bradley DA, Looi LM, Mahmood CS, Wood AK
    Appl Radiat Isot, 1993 Mar;44(3):511-6.
    PMID: 8472024
    Multi-elemental quantitative analyses of 15 paired samples of normal and malignant human breast tissue by instrumental neutron activation analysis are reported. The elements, Al, Br, Ca, Cl, Co, Cs, Fe, K, Na, Rb, Zn were detected. Significantly elevated concentration levels were found for Al, Br, Ca, Cl, Cs, K, Na, Zn in malignant compared to normal tissue. Although the role of elemental composition in breast cancer is unclear, this finding may be of importance as another parameter for differentiating normal from malignant tissue.
    Matched MeSH terms: Trace Elements/analysis*
  17. Ong MC, Gan SL
    Mar Pollut Bull, 2017 Nov 30;124(2):1001-1005.
    PMID: 28807418 DOI: 10.1016/j.marpolbul.2017.08.019
    A study had been carried out to determine Cu, Zn, Cd, Hg and Pb concentrations in the muscle and fins of four elasmobranchs species namely spot-tail sharks, milk sharks, whitespotted bamboo sharks and whitespotted guitarfish from Pulau Kambing LKIM Fishery Complex, Kuala Terengganu, Malaysia. Zinc level was found to have the highest concentration whereas Cd had the lowest concentration in both organs. By comparing both organs, metals concentrations in fins of all elasmobranchs species were higher than muscle. Result obtained was compared with the guidelines set by Malaysian Food Regulation and the provisional tolerable weekly intake was also determined. Current study recommends that the muscle of whitespotted bamboo shark from Kuala Terengganu Waters is likely not to be consumed due to it exceeded the allowable consumption guideline. Finding of this paper is very useful as it provides the baseline data on the pollution status of elasmobranchs in Kuala Terengganu Waters.
    Matched MeSH terms: Trace Elements/analysis*
  18. Usman UA, Yusoff I, Raoov M, Hodgkinson J
    Environ Geochem Health, 2020 Oct;42(10):3079-3099.
    PMID: 32180058 DOI: 10.1007/s10653-020-00543-0
    The research study was carried out to evaluate trace metals (Pb, Cd, Se, Al, Mn, Cu, Zn, Fe, As, Ni, Cr, and Ag) concentrations in groundwater of Lorong Serai 4, Hulu Langat, Selangor, Malaysia. Additionally, the research study focused on determining non-carcinogenic and carcinogenic health risks, sources of the contaminants, and effective remediation methods. The results show that the concentration levels of Pb, Cd, Se, Al, Cu, Zn, Ni, Cr, and Ag are lower than their corresponding permissible limits, while Fe, Mn, and As concentrations exceed their acceptable limit. The hazard index of the groundwater in the area exceeded the acceptable limit, showing the rate of carcinogenic and non-carcinogenic health effects associated with the water. The findings also indicate that the lifetime cancer risk is high compared to the maximum limits of lifetime cancer risk from the drinking water (10-6 to 10-4). The groundwater geochemical data of the area are used in establishing the source of Fe, Mn, and As metal ions. Evaluation of Fe2+/Fe3+ and S2-/SO42- redox couples and thermodynamic modelling indicates that the groundwater of the area is in redox disequilibrium. The groundwater samples contain aqueous iron sulphate, which is supersaturated, ferrous carbonate and aluminium sulphate that are saturated. The main state of redox disequilibrium is governed by mineral precipitation and dissolution. Aqueous arsenic and manganese are possibly derived from the dissolution of pyrite (arsenopyrite) and amorphous oxide-hydroxides, respectively. The high concentration of iron in the shallow groundwater in the area is primarily the result of silicate rock weathering of ferroan igneous and metamorphic minerals with a minor contribution from the oxidation of iron sulphides. Magnetite coated with graphene oxide (Fe3O4-GO) nanoparticles (NPs) was synthesized and characterized, and the adsorption preliminary experiments were carried out; and the Fe3O4-GO NPs show enhanced removal (Fe > As > Mn) capacity over graphene oxide (GO).
    Matched MeSH terms: Trace Elements/analysis*
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