MyMedR

Soft-tissue sarcomas in the Asia-Pacific region: a systematic review

Ngan R, Wang E, Porter D, Desai J, Prayogo N, Devi B, et al.

Asian Pac J Cancer Prev, 2013;14(11):6821-32.

BACKGROUND: Soft-tissue sarcomas require tailored and multidisciplinary treatment and management. However, little is known about how sarcomas are treated and managed throughout the Asia-Pacific region.

MATERIALS AND METHODS: MEDLINE was systematically searched using prespecified criteria. Publications (previous 10 years) that reported tumour characteristics, treatment patterns, survival outcomes, and/or safety outcomes of patients with soft-tissue sarcoma were selected. Exclusion criteria were studies of patients <18 years of age; ≤ 10 patients; countries other than Australia, Hong Kong, Indonesia, Korea, Malaysia, New Zealand, Philippines, Singapore, Taiwan, or Thailand; >20% benign tumours; sarcomas located in bones or joints; gastrointestinal stromal tumour; Kaposi's sarcoma; or not reporting relevant outcomes.

RESULTS: Of the 1,822 publications retrieved, 35 (32 studies) were included. Nearly all patients (98%, 1,992/2,024; 31 studies) were treated with surgery, and more studies used adjuvant radiotherapy than chemotherapy (24 vs 17 studies). Survival outcomes and recurrence rates varied among the studies because of the different histotypes, sites, and disease stages assessed. Only 5 studies reported safety findings.

CONCLUSIONS: These findings highlight the lack of specific data available about soft-tissue sarcomas in the Asia-Pacific region. Better efforts to understand how the sarcoma is managed and treated will help improve patient outcomes in the region.

Matched MeSH terms: Sarcoma/diagnosis; Sarcoma/epidemiology; Sarcoma/prevention & control*

Infratemporal Fossa Synovial Sarcoma In A 3-Month-Old Infant: An Extremely Rare Tumour In Infancy

Lamry NA, Misron K, Tengku Kamalden TMI, Mohamad S

Gulf J Oncolog, 2021 Sep;1(37):91-94.

PMID: 35152201

Soft tissue sarcoma, especially synovial sarcoma is extremely rare in infancy. Only few cases were reported, and challenges lies in disease eradication and subsequent adjuvant therapy. Due to particularly small size of head and neck region with important structures are in intimate location with each other, surgical resection is very challenging, in order to ensure total disease resection as well as maintaining function and cosmetic outcome post-operatively. We present an uncommon case of synovial sarcoma of infratemporal fossa diagnosed in a 3-month-old infant. Due to extreme age, it poses difficulty to the managing team with regards to surgical intervention and oncological regimes. Keywords : Synovial sarcoma; infratemporal fossa; infant.

Matched MeSH terms: Sarcoma*

Fulltext Synovial Sarcoma of the Extremities. A Diagnosis that is Easily Missed.

Pan, K.L., Prem, S.S., Chan, W.H., Haniza S.

Malays Orthop J, 2009;3(2):12-15.

MyJurnal

Synovial sarcoma of the extremities is an uncommon type of soft tissue sarcoma occuring predominantly in young adults at the para-articular regions. We present a series of 10 patients with an average age of 44 years and include a follow-up of 39 months. Eight patients had a surgical procedure for a mistaken benign lesion. In contrast to other soft tissue sarcomas, the swellings were associated with pain and most were fixed to the underlying structures. Five patients had a local reccurence after many years, stressing the necessity for close and long-term follow-up in these patients.

Matched MeSH terms: Sarcoma; Sarcoma, Synovial

Some neuropathologic aspects of intracranial sarcomas

Arumugasamy N

Med J Malaya, 1969 Mar;23(3):169-73.

PMID: 4240068

Matched MeSH terms: Sarcoma/pathology*

Fulltext Parapharyngeal space synovial sarcoma

Lina LC, Rosalind S, Philip R, Ann CP

Med J Malaysia, 2011 Oct;66(4):379-80.

PMID: 22299567 MyJurnal

Synovial sarcoma is a rare soft tissue sarcoma that commonly involves the lower extremities and occurs predominantly in young adults. It very rarely occurs in the head and neck region and carries a poor prognosis. The tumor demonstrates both a loco-regional and a systemic pattern of spread that makes management challenging. Combined modality therapy of this aggressive tumor yields better results. Herein, we described a 58 years old lady presented with left parapharyngeal synovial sarcoma. This is to demonstrate the aggressiveness of the disease despite complete surgical excision followed by post operative radiotherapy. Local regional control was difficult and recurrence of disease was seen in this particular patient.

Matched MeSH terms: Sarcoma, Synovial/pathology; Sarcoma, Synovial/therapy*

Fulltext Ewing's sarcoma of the talus in a four-year-old child

Rasit AH, Sharaf I, Rahman HA

Med J Malaysia, 2001 Jun;56 Suppl C:86-8.

PMID: 11814259

Ewing's sarcoma is a rare malignant tumor of the foot in children. We report a case of Ewing's sarcoma of the talus in a four-year-old Chinese girl to highlight the initial difficulty in diagnosis and the clinical course of the disease. She was initially diagnosed as osteomyelitis of the talus and died eight months after presentation with pleural and spinal metastases. To the best of our knowledge, Ewing's sarcoma of the talus in a young child has never been reported in Malaysia.

Matched MeSH terms: Sarcoma, Ewing/pathology*; Sarcoma, Ewing/radiography*

Fulltext A report of two non-AIDS associated Kaposi's sarcoma in Malaysia

Choon SE, Khoo JJ

Med J Malaysia, 1997 Dec;52(4):437-40.

PMID: 10968124

Kaposi's sarcoma is an uncommon cutaneous neoplasm seen classically in elderly males of East European or Jewish extract. It has been known to be endemic in sub-Saharan Africa for many years. Numerous cases had been described in patients on long-term immunosuppressive therapy and in patients living with acquired immunodeficiency syndrome (AIDS). In spite of the increasing number of organ transplant recipients and people living with AIDS. Kaposi's sarcoma remains rare in Asia. We report two cases seen in Johor, Malaysia.

Matched MeSH terms: Sarcoma, Kaposi/etiology*; Sarcoma, Kaposi/therapy

Transducer-like enhancer of split 1 (TLE1) expression as a diagnostic immunohistochemical marker for synovial sarcoma and its association with morphological features

Bakrin IH, Hussain FA, Tuan Sharif SE

Malays J Pathol, 2016 Aug;38(2):117-22.

PMID: 27568668 MyJurnal

Synovial sarcoma (SS) is a malignant soft tissue tumour of uncertain histogenesis which is defined by the translocation t(X;18) that produces the fusion oncogenes SYT-SSX. The emergence of transducer-like enhancer of split 1 (TLE1) as a new immunohistochemical (IHC) marker for SS has offered an alternative to pathologists in differentiating SS from other histological mimics, especially in the setting of limited molecular facilities. We investigated the utility of IHC TLE1 expression against histomorphological features and other IHC markers in SS and non-SS tumours. Twenty-six cases of histologically diagnosed SS and 7 non-SS (for which SS was in the differential diagnosis) were subjected to TLE1 IHC staining, which was graded from 0 to 3+. Of the 26 SS cases, 12 each were biphasic and monophasic types and 2 were poorly-differentiated. TLE1 was expressed in 22/26 (84.6%) SS cases, of which 11/12 (91.7%) were biphasic, 10/12 (83.3%) monophasic and 1/2 (50%) poorly-differentiated tumours. Two of 7 (28.6%) non-SS cases were positive for TLE1. Immunopositivity of SS and non-SS cases for EMA were 20/26 (76.9%) and 2/7 (28.6%) respectively and for CK7 were 7/26 (26.9%) and 0/7 (0%) respectively. All cases were negative for CD34. Consistent histomorphological features for SS included mild nuclear pleomorphism, alternating tumour cellularity, fascicular growth pattern and thick ropy stromal collagen. In conclusion, TLE1 is not a stand-alone diagnostic IHC marker for SS. However, in the absence of molecular studies, it can contribute added diagnostic value in combination with morphological evaluation and other IHC markers such as EMA and CD34.

Matched MeSH terms: Sarcoma, Synovial/diagnosis*; Sarcoma, Synovial/pathology

Fulltext Kaposi's sarcoma: case report and treatment options

Tan WC, Chan LC

Med J Malaysia, 2011 Oct;66(4):383-4.

PMID: 22299569

Kaposi's sarcoma (KS) is strongly associated with Human Herpes Virus 8 (HHV8) and Human Immunodeficiency Virus infection (HIV). It was the first malignancy to be linked with Acquired Immunodeficiency Syndrome (AIDS). We report a case of Kaposi's sarcoma in a newly diagnosed retroviral homosexual patient with CD4 count of 21. He had multiple firm discrete violaceous plaques and nodules scattered over the face, scalp, hard palate, trunk and genitalia. Biopsy of a skin nodule over the trunk and a biopsy of a lesion from the gastric mucosa confirmed Kaposi's sarcoma. He was started on Highly Active Antiretroviral Therapy (HAART) and cryotherapy (liquid nitrogen) was given for the lesions over the skin. He responded well to treatment. Liquid nitrogen is a useful adjuvant treatment for Kaposi's sarcoma.

Matched MeSH terms: Sarcoma, Kaposi/therapy*

Thoracic sarcoma case series in Hospital Kuala Lumpur, Malaysia

Yurkdes AS, Narasimman S

Med J Malaysia, 2019 Jun;74(3):237-239.

PMID: 31256182

Thoracic sarcomas (TS) are rare neoplasms that may present with non-specific pulmonary symptoms. Chest radiographs and computed tomography of the thorax are the investigations of choice, while pre-operative minimally invasive biopsies may not be entirely helpful with the diagnosis. The commonly identified variants of thoracic sarcomas include liposarcomas, leiomyosarcomas and synovial sarcomas. Complete excision of the tumour with clear margins remain the sole definite form of management and there is limited role with adjuvant chemotherapy and radiotherapy. In the present case series, we explore our experience with three patients who presented with TS and the management decisions that was made.

Matched MeSH terms: Leiomyosarcoma; Liposarcoma; Sarcoma; Sarcoma, Synovial

Alveolar soft part sarcoma: a case report

Sengupta S, Murugasu R

Med J Malaya, 1970 Sep;25(1):70-2.

PMID: 4249502

Matched MeSH terms: Sarcoma/pathology*

Growth of Toxoplasma gondii in sarcoma 180 mouse ascites tumor cells

Zaman V

Med J Malaya, 1968 Mar;22(3):195-7.

PMID: 4234355

Matched MeSH terms: Sarcoma 180*

Two diseases in the same patient

CHIA M

Med J Malaya, 1957 Mar;11(3):247-9.

PMID: 13477003

Matched MeSH terms: Sarcoma*; Osteosarcoma*

Fulltext Gastrointestinal bleeding caused by epitheloid sarcoma: A case report

Lee FY, Lim L, Gee T

Med J Malaysia, 2016 Aug;71(4):215-216.

PMID: 27770126 MyJurnal

Epithelioid sarcoma (ES) of the small bowel is a rare gastrointestinal tumour. We report a case of gastrointestinal bleeding secondary to small bowel ES in a 55-year-old gentleman. After gastroscopy and colonoscopy failed to identify the source of bleeding, we proceeded with computed tomography angiogram of the mesentery, which revealed intraluminal blood clot in the distal jejunum with features of obstruction. This is a rare cause of obscure gastrointestinal bleeding and emphasises the need for additional evaluation in the presence of negative endoscopic findings.

Matched MeSH terms: Sarcoma*

Synovial sarcoma of the ethmoidal sinus

Wong HT, Ho CY, Nazarina AR, Prepageran N

J Laryngol Otol, 2014 Nov;128(11):1022-3.

PMID: 25274107 DOI: 10.1017/S0022215114002151

Synovial sarcoma is a high-grade, soft tissue, malignant disease associated with poor outcome. Typically, synovial sarcoma involves the extremities, with less than 10 per cent of cases occurring in the head and neck region. Synovial sarcoma of the paranasal sinuses is a rare entity. This paper presents a case of an elderly patient with synovial sarcoma of the ethmoidal sinus.

Matched MeSH terms: Sarcoma, Synovial/pathology*; Sarcoma, Synovial/radiotherapy; Sarcoma, Synovial/surgery

Fulltext The outcome of pleomorphic sarcoma at University Malaya Medical Center--a fifteen-year review

Chan CYW, Janarthan N, Vivek AS, Jayalakshmi P

Med J Malaysia, 2008 Oct;63(4):311-4.

PMID: 19385491

Pleomorphic sarcoma is the most common sarcoma. Reports of outcome as well as evaluation of prognostic factors in the literature show great variation. We looked at our experience in treating this tumour at University Malaya Medical Center. This is a review of patients diagnosed with Pleomorphic Sarcoma from January 1990 to December 2005 at University Malaya Medical Center. Outcome measures studied are the overall survival, disease free survival and local recurrence of disease. Prognostic factors for survival and local recurrence which were studied are the tumour size, depth, stage, type of surgery, adjuvant therapy, and surgical margin. There were fifty four patients available for analysis of demographics. The mean age at presentation was 52.3 +/- 16.7 years. There were thirty male patients (56%) and twenty four female patients (44%) in the study population. The patients were predominantly Malay (44.4%) and Chinese (42.6%). There were two Indian patients (3.7%) and five patients from other races (9.3%). Thirty patients had disease affecting the extremities while six patients had disease affecting the trunk. Patients with tumour affecting the trunk had 100% mortality. In patients with tumour affecting the extremity, 46.7% presented with Stage 3 disease. The overall median survival was 39 months. The overall survival rate at 3 years was 53.3% and the 5 years was 30.0%. The disease free survival rate at five years was 27.6%. However, if patients who presented with metastasis were excluded, the 5 year survival rate was 60% while the disease free survival was 53.3%. Recurrence rate was 33.3%. Factors affecting survival was stage, size and location of tumour. No factors were found to correlate with higher local recurrence rate. In conclusion, Pleomorphic Sarcoma is a heterogenous disease with variable outcome. In our centre, late presentation with advanced disease significantly affects the overall outcome of this condition. Tumour size and location are important prognostic factors. Inherent tumour behavior and aggressiveness probably outweigh current treatment modalities as the most important prognostic factor in the management of Pleomorphic Sarcoma.

Matched MeSH terms: Sarcoma/mortality*; Sarcoma/pathology; Sarcoma/therapy

Fulltext Can a chronic expanding haematoma mimic a soft tissue sarcoma?

Muniandy M, Singh VA

BMJ Case Rep, 2009;2009.

PMID: 21686602 DOI: 10.1136/bcr.09.2008.0846

A 68-year-old woman presented with a gradually increasing left gluteal swelling that she had first noted 2 years previously. The results of both clinical and radiological examinations were consistent with soft tissue sarcoma, but the final diagnosis after resection was haematoma.

Matched MeSH terms: Sarcoma

Aleukemic bcr-abl positive granulocytic sarcoma

Kuan JW, Pathmanathan R, Chang KM, Tan SM

Leuk. Res., 2009 Nov;33(11):1574-7.

PMID: 19215983 DOI: 10.1016/j.leukres.2009.01.016

Granulocytic sarcoma (GS) can occur de novo or in association with intramedullary myeloid disorders. With the advent of sophisticated molecular detection techniques to detect diagnostic genes such as bcr-abl, PML-RARA and CBFB/MYH11 in bone marrow or peripheral blood, many cases of the so called 'primary' GS are questionable. We report a case of primary GS where the tumor mass bcr-abl translocation was demonstrated by fluorescent in situ hybridization in which there was no evidence of chronic myeloid leukemia (CML). This is an important finding as it highlights the possibility that CML may present as a sole extramedullary form, and illustrates potential treatment by tyrosine kinase inhibitor.

Matched MeSH terms: Sarcoma, Myeloid/diagnosis*; Sarcoma, Myeloid/drug therapy; Sarcoma, Myeloid/genetics

Clear cell sarcoma of kidney: a clinicopathological study of eight cases from Malaysia

Cheah PL, Looi LM, Lin HP

Histopathology, 1992 Oct;21(4):365-9.

PMID: 1328018

Eight cases of clear cell sarcoma of kidney were seen in the Department of Pathology, University Hospital, Kuala Lumpur, Malaysia over the 16-year period from 1973 to 1989. Five of the patients were males. Six patients were Malay, one Chinese and one Indian. The patients' ages ranged from 8 months to 3 years. Clear cell sarcoma was the original diagnosis in two patients while six were diagnosed as blastemal-predominant Wilms' tumours at presentation. Metastases developed in five patients. Metastatic sites included the thoracic vertebra, skull, orbit, humerus, radius, ulna, shoulder, lung and liver. The prolonged survival, of 9 years and 9 months, seen in one patient despite omission of Adriamycin (doxorubicin) from the chemotherapeutic protocol is highlighted. We also emphasise the histological factors which are of help in differentiating clear cell sarcoma from Wilms' tumour.

Matched MeSH terms: Sarcoma/pathology*; Sarcoma/secondary; Sarcoma/therapy

Fulltext Apoptotic activities in soft tissue sarcoma: immunohistochemical study and their association with tumour characteristics

Win TT, Yusuf Y, Jaafar H

Malays J Med Sci, 2013 Mar;20(2):10-6.

PMID: 23983572 MyJurnal

Many studies on the role of apoptosis in cancer development and management have been undertaken. Apoptotic activity depends partly on the balance between anti-apoptotic (Bcl-2) and pro-apoptotic (Bax) activities. This study compared Bcl-2 and Bax expression in the tumour cells and endothelial cells of tumour blood vessels in soft tissue sarcoma, and examined the association of these with tumour characteristics.

Matched MeSH terms: Sarcoma

Displaying publications 1 - 20 of 109 in total