The Generation End Game (GEG) policy plan represents a groundbreaking initiative by the Malaysian government aimed at creating a smoke-free generation. This cross-sectional study aims to explore the factors influencing knowledge, attitude and perception of Malaysian adolescents towards the policy. A quantitative pre- and post-test survey was conducted among 731 adolescents born in 2007 and above across Malaysia, following a brief informational introduction to the GEG policy. This study utilized ANCOVA and binomial logistic regression to assess the association between various sociodemographic factors with knowledge, attitude and perceptions of the GEG. The results reveal that gender, tobacco-related experiences, peer influences, and health-related beliefs significantly impacted perception outcomes (p