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  1. Hajjar T, Meng GY, Rajion MA, Vidyadaran S, Othman F, Farjam AS, et al.
    BMC Neurosci, 2012;13:109.
    PMID: 22989138 DOI: 10.1186/1471-2202-13-109
    This study examined the effects of dietary polyunsaturated fatty acids (PUFA) as different n-6: n-3 ratios on spatial learning and gene expression of peroxisome- proliferator-activated receptors (PPARs) in the hippocampus of rats. Thirty male Sprague-Dawley rats were randomly allotted into 3 groups of ten animals each and received experimental diets with different n-6: n-3 PUFA ratios of either 65:1, 22:1 or 4.5:1. After 10 weeks, the spatial memory of the animals was assessed using the Morris Water Maze test. The expression of PPARα and PPARγ genes were determined using real-time PCR.
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