METHODS: A comparative analysis of the four AI platforms was conducted using structured questions and clinical case scenarios on varicella and measles. Responses were evaluated for alignment with CDC guidelines. Platform accessibility was tested from Canada, Malaysia, and the United Kingdom, and regional variations were analyzed.
RESULTS: All platforms provided generally accurate information, but discrepancies were noted. ChatGPT and Meta AI mostly aligned with CDC guidelines, while OpenEvidence and Copilot omitted key epidemiological criteria. Meta AI lacked a full explanation of varicella laboratory criteria and was inaccessible in Malaysia. Regional differences in measles postexposure prophylaxis (PEP) were observed, particularly in Copilot and OpenEvidence. Response consistency varied between platforms.
CONCLUSIONS: AI platforms show promise in supporting infection control but exhibit regional variability. Continued refinement of AI tools is essential to ensure their global applicability and accuracy. Consultation with an infection prevention and control (IPAC) physician remains vital for complex cases.