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  1. Fulltext Towards global consensus on core outcomes for hidradenitis suppurativa research: an update from the HISTORIC consensus meetings I and II
    Thorlacius L, Garg A, Ingram JR, Villumsen B, Theut Riis P, Gottlieb AB, et al.
    Br J Dermatol, 2018 03;178(3):715-721.
    PMID: 29080368 DOI: 10.1111/bjd.16093
    BACKGROUND: A core outcomes set (COS) is an agreed minimum set of outcomes that should be measured and reported in all clinical trials for a specific condition. Hidradenitis suppurativa (HS) has no agreed-upon COS. A central aspect in the COS development process is to identify a set of candidate outcome domains from a long list of items. Our long list had been developed from patient interviews, a systematic review of the literature and a healthcare professional survey, and initial votes had been cast in two e-Delphi surveys. In this manuscript, we describe two in-person consensus meetings of Delphi participants designed to ensure an inclusive approach to generation of domains from related items.

    OBJECTIVES: To consider which items from a long list of candidate items to exclude and which to cluster into outcome domains.

    METHODS: The study used an international and multistakeholder approach, involving patients, dermatologists, surgeons, the pharmaceutical industry and medical regulators. The study format was a combination of formal presentations, small group work based on nominal group theory and a subsequent online confirmation survey.

    RESULTS: Forty-one individuals from 13 countries and four continents participated. Nine items were excluded and there was consensus to propose seven domains: disease course, physical signs, HS-specific quality of life, satisfaction, symptoms, pain and global assessments.

    CONCLUSIONS: The HISTORIC consensus meetings I and II will be followed by further e-Delphi rounds to finalize the core domain set, building on the work of the in-person consensus meetings.

  2. The Cost-Of-Living Crisis and Suicide Rates
    Pirkis J, Shin S, Roberts L, Arya V, Agrest M, Aguilar PA, et al.
    Crisis, 2026 Oct 27.
    PMID: 42935141 DOI: 10.1027/0227-5910/a001077
    Background: The cost-of-living crisis may be contributing to suicide rates, but this has not been adequately tested. Aims: We aimed to determine whether the cost-of-living crisis is associated with suicide rates in multiple countries and areas-within-countries. Method: We sourced country- and area-within-country-level monthly suicide data at a minimum from January 1, 2019, to December 31, 2022 (and at a maximum from January 1, 2016, to June 30, 2023), and population denominator and monthly headline consumer price index (CPI) data. We calculated the yearly change in inflation as the percentage change in CPI for one month versus the equivalent month in the previous year. We estimated associations between yearly change in inflation (lagged by one month) and suicide rates for each country and area-within-country, using autoregressive negative binomial regression. We summarized results using weighted means. Results: We obtained data on 1,372,994 suicides from 54 countries. At the country-level, for every 1.0% increase in yearly inflation in the previous month, there was an average 0.2% increase in suicide rates. The association was strongest in those aged 30-49 and 50-69; for every 1.0% increase in yearly inflation in the previous month, there were 0.3% and 0.6% increases in suicide rates for these age-groups, respectively. This pattern held for males in these age-groups, with increases of the same magnitude, and for females aged 50-69, with a 0.8% increase. At the area-within-country-level, the picture was even starker. Limitations: Study limitations include: the ecological design; the single measure of inflation; potential variations in suicide data quality; lack of representation by low-and-middle-income countries (LMICS); lack of availability of sex, age and sex/age breakdowns for some countries and areas-within-countries; and potential issues with multiple testing. Conclusions: There is an association between the cost-of-living crisis and suicide rates internationally. Public and social policies that improve people's circumstances are critical.
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