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  1. Surohedin IH, Ganes T, Yee A, Abd Rashid R, Lim PK
    J Ethn Subst Abuse, 2025 Feb 16.
    PMID: 39955636 DOI: 10.1080/15332640.2025.2457618
    BACKGROUND: The use of non-medical opioids has reached 60 million in 2021. Methadone-assisted treatment (MAT) is a widely used harm-reduction strategy for opioid addiction. However, methadone can cause cognitive impairment, which can impede treatment.

    METHODS: This cross-sectional study was conducted between July 1st and July 31, 2023. A total of 114 participants, comprising 76 MAT patients and 38 healthy subjects (controls), were recruited. Sociodemographic questionnaire, DSM-5 and neuropsychiatric cognitive (NUCOG) assessments were used. A general linear model was used to examine cognitive function between the MMT and control groups while controlling for all possible confounders.

    RESULTS: The MAT group performed significantly lower on the NUCOG total score (p 

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