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  1. Borromeo AS, Villanueva A, Torres J, Rayray BM, Darilag A, Wider W
    Asian Nurs Res (Korean Soc Nurs Sci), 2026 Oct;20(4):357-367.
    PMID: 42142579 DOI: 10.1016/j.anr.2026.05.001
    PURPOSE: This study mapped the global intellectual and thematic structure of nursing leadership research by integrating three often separate domains: governance, succession, and equity. It examined how these domains are connected in the literature across nursing education and practice.

    METHODS: We conducted a bibliometric analysis of Web of Science Core Collection records (1970-2025) using a tri-lens search strategy, yielding 315 peer-reviewed articles. We then performed co-citation and co-word network analyses in VOSviewer (version 1.6.20; Centre for Science and Technology Studies, Leiden University, Leiden, The Netherlands) using association-strength normalization. Thematic mapping was conducted in Biblioshiny, the web interface of the bibliometrix R package (version 5.0; developed by Aria and Cuccurullo, Naples, Italy), using Louvain clustering and Callon's centrality and density matrix to classify themes as motor, basic, niche, or emerging/declining.

    RESULTS: The data set accrued 4402 citations (H-index = 31), with publication growth accelerating after 2015. Co-citation analysis identified four intellectual pillars: (1) leadership capacity building, (2) equity-focused leadership, (3) transition and workforce development, and (4) policy-driven leadership preparation. Co-word analysis also produced four thematic clusters: academic leadership, simulation-based preparation, equity/racism in leadership, and staff development across education-practice-research contexts. Across both maps, governance-, succession-, and equity-related topics were adjacent but largely concentrated in separate cluster communities, with limited cross-cluster connectors.

    CONCLUSION: Nursing leadership research is expanding but remains structurally fragmented across governance, succession, and equity domains. The key contribution of this study is the tri-lens evidence that these domains are conceptually related yet weakly integrated in empirical knowledge structures. Findings support the need to align governance design, leadership pipeline development, and equity mechanisms in nursing education and leadership planning.

  2. Marques Da Costa ME, Zaidi S, Scoazec JY, Droit R, Lim WC, Marchais A, et al.
    Commun Biol, 2023 Sep 18;6(1):949.
    PMID: 37723198 DOI: 10.1038/s42003-023-05320-0
    Pediatric patients with recurrent and refractory cancers are in most need for new treatments. This study developed patient-derived-xenograft (PDX) models within the European MAPPYACTS cancer precision medicine trial (NCT02613962). To date, 131 PDX models were established following heterotopical and/or orthotopical implantation in immunocompromised mice: 76 sarcomas, 25 other solid tumors, 12 central nervous system tumors, 15 acute leukemias, and 3 lymphomas. PDX establishment rate was 43%. Histology, whole exome and RNA sequencing revealed a high concordance with the primary patient's tumor profile, human leukocyte-antigen characteristics and specific metabolic pathway signatures. A detailed patient molecular characterization, including specific mutations prioritized in the clinical molecular tumor boards are provided. Ninety models were shared with the IMI2 ITCC Pediatric Preclinical Proof-of-concept Platform (IMI2 ITCC-P4) for further exploitation. This PDX biobank of unique recurrent childhood cancers provides an essential support for basic and translational research and treatments development in advanced pediatric malignancies.
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