OBJECTIVE: This study aims to determine sociodemographic factors associated with the severity of anemia among under-five children in Kut City.
METHODS: A cross-sectional study with a convenience sample (non-probability) was conducted among 264 children admitted to hospitals in Kut City, from September 1st, 2022, to March 1st, 2023. Data were collected via questionnaires, and descriptive and inferential statistics were used to evaluate the data.
RESULTS: The total number of children participating in the study was 264, with 39.0% having mild anemia and 60.0% having moderate anemia, according to the World Health Organization classification of anemia. The results showed that the children most at risk of developing anemia were within 4 years of age and had a lower mean hemoglobin level than the rest of the age groups of the children participating in the study, compared to the mean+standard deviation (SD) (9.46+0.99). Boys are more affected than girls, and those who reside in rural areas have lower hemoglobin (HB) percentages with a mean+SD of (9.21+0.93). Unemployed mothers who read and write had the lowest HB percentage. In contrast, parents with primary education and government jobs have the lowest percentage of HB. Children of married mothers are more affected by anemia. Families with high overcrowding showed the lowest rate of HB. They experienced low socioeconomic status as a result. The degree of anemia was significantly correlated with the child's age, residence, mother's educational level, father's job, and socioeconomic position.
CONCLUSION: This study concludes a significant association between the severity of anemia and sociodemographic factors, both unmodifiable (age) and modifiable (residence, mothers' education, fathers' jobs, and economic and social status). Children with modifiable risk factors need to have their anemia risk constantly evaluated.
OBJECTIVE: This study aims to predict the potential of 17 compounds owned by the vanillin analog to COX-1 receptor using in silico.
METHODS: This research employed a molecular docking analysis using Toshiba hardware and AutoDock Tools version 1.5.7, ChemDraw Professional 16.0, Discovery Studio, UCSF Chimera software, SWISSADME and pKCSM, a native ligand from COX- 1 (PDB ID: 1CQE) was validated.
RESULTS: The validation result indicated that the RMSD was <2 Å. The 4-formyl-2-methoxyphenyl benzoate compound had the lowest binding energy in COX-1 inhibition with a value of -7.70 Å. All vanillin derivatives show good intestinal absorption, and the predicted toxicity indicated that they were non-hepatotoxic. All these compounds have the potential to be effective antithrombotic treatments when consumed orally.
CONCLUSION: In comparison to other vanillin derivative compounds, 4-formyl-2-methoxyphenyl benzoate has the lowest binding energy value; hence, this analog can continue to be synthesized and its potential as an antithrombotic agent might be confirmed by in vivo studies.