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  1. Treatment of chronic urticaria with thyroxine in an euthyroid patient with thyroglobulin and microsomal antibodies
    Koh CK, Hew FL, Chiu CL
    Ann Acad Med Singap, 2000 Jul;29(4):528-30.
    PMID: 11056786
    INTRODUCTION: The association of chronic urticaria and thyroid autoimmunity is not well recognised and the potential use of thyroxine in the treatment of chronic urticaria in patients with thyroid autoimmunity is even less well known.

    CLINICAL PICTURE: We report a case of chronic urticaria in an euthyroid patient with evidence of significantly elevated levels of thyroglobulin and microsomal antibodies.

    TREATMENT AND OUTCOME: Treatment with thyroxine has brought about clinical remission of the chronic urticaria but no change in the thyroid antibody levels could be demonstrated.

    CONCLUSION: Patients with chronic urticaria should be screened for evidence of thyroid autoimmunity. A closely monitored trial of thyroxine therapy for those who have thyroid autoimmunity can be rewarding.

    Matched MeSH terms: Thyroiditis, Autoimmune/immunology
  2. Usefulness and limitations of thyrotropin measurements as a first-line test for follow-up of Graves' patients
    Ng ML, Tan TT, Roslan BA, Rajna A, Khalid BA
    Ann Acad Med Singap, 1993 Jul;22(4):569-72.
    PMID: 7504901
    We evaluated the usefulness of sensitive thyrotrophin hormone (TSH) measurements in determining the thyroid status in the follow-up of Graves' patients undergoing medical treatment with thionamides. Out of a total of 186 serum samples tested, TSH levels were suppressed in 123 (66.1%), normal in 32 (17.2%) and elevated in 31 (16.7%) cases. Total T4, or T3 or both were elevated only in 97 (74.8%) cases of TSH-suppressed patients, indicating that TSH is less discriminatory as a first-line test for patients under treatment due to the hypothalamic-pituitary lag period. No comparisons with free T4 or free T3 were done in this study. Both total T4 (120 +/- 28 nmol/l) and TBII (23 +/- 21%) levels were significantly greater (p < 0.02) in the euthyroid group with suppressed TSH. This may suggest that persistence of a thyrotoxic state may still be present.
    Matched MeSH terms: Thyroiditis, Autoimmune/immunology
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