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  1. Lifestyle intervention improves cardiometabolic profiles among children with metabolically healthy and metabolically unhealthy obesity
    Wan Mohd Zin RM, Jalaludin MY, Md Zain F, Hong JYH, Ahmad Kamil NZI, Mokhtar AH, et al.
    Diabetol Metab Syndr, 2024 Nov 11;16(1):268.
    PMID: 39523406 DOI: 10.1186/s13098-024-01493-8
    BACKGROUND: In recent years, there has been a surge of interest in the metabolic phenotype among children with obesity characterized by the absence of associated cardiometabolic risk factors (CRFs), known as metabolically healthy obesity (MHO), as opposed to those with metabolically unhealthy obesity (MUO). This study investigated the effect of lifestyle intervention on CRFs among children with MHO and MUO.

    METHODS: A total of 102 school-aged children with obesity (54 girls and 48 boys) aged 8-16 years completed a 16-week school-based lifestyle modification intervention program, MyBFF@school Phase I. The intervention consisted of physical activity, healthy eating promotion, and psychological empowerment. MHO and MUO statuses were defined based on the 2018 consensus-based criteria. Fasting venous blood collection, body composition measurement, clinical assessment and physical fitness testing were conducted at baseline and at the end of week 16.

    RESULTS: After the intervention, the CRFs of the children with MUO improved with significant decreases in systolic (p 

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