MyMedR

Fulltext Genetic association in myocardial infarction. Ethnicity; ABO, Rh, Le, Xg blood groups; G6PD deficiency; and abnormal haemoglobins

Saha N, Toh CC, Ghosh MB

J Med Genet, 1973 Dec;10(4):340-5.

PMID: 4204387

Fulltext Socio-demographic Factors of Geriatric Depression

Barua A, Ghosh MK, Kar N, Basilio MA

Indian J Psychol Med, 2010 Jul;32(2):87-92.

PMID: 21716860 DOI: 10.4103/0253-7176.78503

Depression is a common mental health problem in geriatric population and the overall prevalence rate of depression in this age group varies between 10 and 20%.

Fulltext Retraction Note: Weather indicators and improving air quality in association with COVID-19 pandemic in India

Chakrabortty R, Pal SC, Ghosh M, Arabameri A, Saha A, Roy P, et al.

Soft comput, 2023 May 29.

PMID: 37362259 DOI: 10.1007/s00500-023-08596-w

[This retracts the article DOI: 10.1007/s00500-021-06012-9.].

Fulltext Weather indicators and improving air quality in association with COVID-19 pandemic in India

Chakrabortty R, Pal SC, Ghosh M, Arabameri A, Saha A, Roy P, et al.

Soft comput, 2023;27(6):3367-3388.

PMID: 34276248 DOI: 10.1007/s00500-021-06012-9

The COVID-19 pandemic enforced nationwide lockdown, which has restricted human activities from March 24 to May 3, 2020, resulted in an improved air quality across India. The present research investigates the connection between COVID-19 pandemic-imposed lockdown and its relation to the present air quality in India; besides, relationship between climate variables and daily new affected cases of Coronavirus and mortality in India during the this period has also been examined. The selected seven air quality pollutant parameters (PM10, PM2.5, CO, NO2, SO2, NH3, and O3) at 223 monitoring stations and temperature recorded in New Delhi were used to investigate the spatial pattern of air quality throughout the lockdown. The results showed that the air quality has improved across the country and average temperature and maximum temperature were connected to the outbreak of the COVID-19 pandemic. This outcomes indicates that there is no such relation between climatic parameters and outbreak and its associated mortality. This study will assist the policy maker, researcher, urban planner, and health expert to make suitable strategies against the spreading of COVID-19 in India and abroad.

SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00500-021-06012-9.

Fulltext Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.

Autophagy, 2021 Jan;17(1):1-382.

PMID: 33634751 DOI: 10.1080/15548627.2020.1797280

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.

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