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Fulltext Multilevel analysis of site, implant, and patient-level factors with peri-implant bleeding on probing: a cross sectional study

Nettemu SK, Nettem S, Singh VP, William SS, Gunasekaran SS, Krisnan M, et al.

Int J Implant Dent, 2021 06 10;7(1):77.
PMID: 34109477 DOI: 10.1186/s40729-021-00315-0

AIM: This study was to evaluate the association between peri-implant bleeding on probing in peri-implant diseases and its association with multilevel factors (site specific factors, implant factors, and patient level factors).
METHODOLOGY: A cross-sectional study involved consented adult patients with ≥ 1 dental implant. Two calibrated operators examined the patients. BoP was outcome variable and peri-implant gingival biotype was principal predictor variable. The effects of site, implant, and patient level factors on BoP were assessed using a multilevel logistic regression model.
RESULTS: Eighty patients for a total of 119 implants and 714 sites were included in the study. Bleeding on probing was observed in 42 implants (35.29%) with a significant higher risk observed in presence of gingival recession, thin peri-implant gingival biotype, duration of implant placement, smokers, and male patients.
CONCLUSION: Peri-implant bleeding on probing was associated with site specific, implant, and patient level factors.
Electrospun nanofibers of collagen and chitosan for tissue engineering and drug delivery applications: A review

Ramakrishnan P, Ramprasath R, Jalaludeen AM, Jayakumar R, Jolius G, Balu R, et al.

Int J Biol Macromol, 2025 Mar;296:139663.
PMID: 39793786 DOI: 10.1016/j.ijbiomac.2025.139663

Tissue engineering plays a vital role in the medical field that addresses the repair, regeneration, and replacement of damaged tissues or organs. The development of drug-eluting electrospun nanofiber composed of biological macromolecules plays a key role in providing localized drug delivery and structural support. This review examines the recent development and impact of electrospun nanofibers in the field of tissue engineering and explores their potential applications. This review also investigates into the fabrication techniques of nanofibers, highlighting the use of biopolymers like collagen and chitosan, chiefly, focuses on understanding the mechanisms of drug-releasing features of these nanofibers. Studies concerning the medical applications of these nanofibers, such as wound healing, skin regeneration, bone tissue engineering, and neural repair, were also reviewed. Beyond the application in tissue regeneration, this review also explores the potential efficacy of nanofibres in cancer therapy, antibacterial activity, enzyme immobilization, and biosensing applications. This study provides an up-to-date critical insight into the applications of electrospun nanofiber application and key scalable production processes, underscoring the potential economic impacts of advanced wound care technologies. While outlining current challenges, this paper also offers future perspectives on the design, application, and potential expansion of drug-eluting electrospun fibers in medical sciences, ultimately showcasing their pivotal role in advancing therapeutic outcomes.

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