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  1. Chandrasekaran R, Madheswaran T, Tharmalingam N, Bose RJ, Park H, Ha DH
    Drug Discov Today, 2021 01;26(1):94-105.
    PMID: 33130336 DOI: 10.1016/j.drudis.2020.10.020
    Gold nanoparticles (AuNPs) have garnered much attention as contrast agents for computerized tomography (CT) because of their facile synthesis and surface functionalization, in addition to their significant X-ray attenuation and minimal cytotoxicity. Cell labeling using AuNPs and tracking of the labeled cells using CT has become a time-efficient and cost-effective method. Actively targeted AuNPs can enhance CT contrast and sensitivity, and further reduce the radiation dosage needed during CT imaging. In this review, we summarize the state-of-the-art use of AuNPs in CT for cell tracking, including the precautionary steps necessary for their use and the difficulty in translating the process into clinical use.
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