Displaying all 5 publications

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  1. Han YL, Wan Sulaiman WS, Ahmad Badayai AR, Abdullah Mohd Nor H
    PMID: 39816895 DOI: 10.3389/frcha.2023.1221933
    INTRODUCTION: The Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-CHAT-R/F) is a two-stage parent-reported tool for screening autism spectrum disorder (ASD). Early detection of ASD is highly associated with improved social communication and reduced restricted and repetitive behaviors associated with ASD. However, there is limited availability of ASD screening tools in Malaysia and there are no relevant validation studies published. The process of modifying a screening instrument to align with the cultural and linguistic characteristics of the target population is a crucial component in establishing the instrument's validity.

    METHODS: Therefore, this study translates and culturally adapts the M-CHAT-R/F into Malay and verifies its psychometric properties among the Malaysian population. 500 Malaysian toddlers aged between 18 and 48 months were recruited from different settings. The parents of the toddlers were asked to complete the Malaysian M-CHAT-R/F. The reliability of the screening tool was verified using Cronbach's alpha.

    RESULTS: By comparing the screening outcomes of the Malaysian M-CHAT-R/F and clinical evaluation results, the prevalence of ASD was determined as 6.6% in the sample. High values of sensitivity (96.6%) and specificity (93.2%) and a satisfactory positive predictive value (47.5%) supported the validity of the Malaysian M-CHAT-R/F. Furthermore, the receiver operating characteristic analysis yielded three as the optimal cut-off score of the Malaysian M-CHAT-R/F.

    DISCUSSION: These results suggest that the Malaysian M-CHAT-R/F is an effective screening tool reliable for use in clinical practice. Further investigation using a representative sample of the whole country is recommended given the high prevalence rate obtained in the current sample.

  2. Han YL, Wang S, Zhang X, Li Y, Huang G, Qi H, et al.
    Drug Discov Today, 2014 Jun;19(6):763-73.
    PMID: 24508818 DOI: 10.1016/j.drudis.2014.01.015
    Regenerative medicine has rapidly evolved over the past decade owing to its potential applications to improve human health. Targeted differentiations of stem cells promise to regenerate a variety of tissues and/or organs despite significant challenges. Recent studies have demonstrated the vital role of the physical microenvironment in regulating stem cell fate and improving differentiation efficiency. In this review, we summarize the main physical cues that are crucial for controlling stem cell differentiation. Recent advances in the technologies for the construction of physical microenvironment and their implications in controlling stem cell fate are also highlighted.
  3. Huo Y, Lee SW, Sawhney JP, Kim HS, Krittayaphong R, Nhan VT, et al.
    Clin Cardiol, 2015 Sep;38(9):511-9.
    PMID: 26206158 DOI: 10.1002/clc.22431
    BACKGROUND: In-hospital and postdischarge mortality for acute coronary syndromes (ACS) vary across Asia and remain generally poorer than globally. The relationship between real-life antithrombotic management patterns (AMPs) and ACS-related outcomes in Asia is unclear.

    METHODS: EPICOR Asia (Long-tErm follow-uP of antithrombotic management patterns In acute CORonary syndrome patients in Asia) (NCT01361386) is a prospective, multinational, observational study of patients discharged after hospitalization for an ACS, with 2-year follow-up. The aim is to describe short- and long-term (up to 2 years post-index event) AMPs in patients hospitalized for ACS and to record clinical outcomes, healthcare resource use, and self-reported health status. Pre- and in-hospital management, AMPs, and associated outcomes, with particular focus on ischemic and bleeding events, will be recorded during the 2-year follow up.

    RESULTS: Between June 2011 and May 2012, 13 005 patients were enrolled. From these, 12 922 patients surviving an ACS (6616 with STEMI, 2570 with NSTEMI, and 3736 with UA) were eligible for inclusion from 219 hospitals across 8 countries and regions in Asia: China (n = 8214), Hong Kong (n = 177), India (n = 2468), Malaysia (n = 100), Singapore (n = 93), South Korea (n = 705), Thailand (n = 957), and Vietnam (n = 208).

    CONCLUSIONS: EPICOR Asia will provide information regarding clinical management and AMPs for ACS patients in Asia. Impact of AMPs on clinical outcomes, healthcare resource use, and self-reported health status both during hospitalization and up to 2 years after discharge will also be described.

  4. Tan JWC, Chew DP, Tsui KL, Tan D, Duplyakov D, Hammoudeh A, et al.
    Eur Cardiol, 2021 Feb;16:e43.
    PMID: 34815751 DOI: 10.15420/ecr.2021.35
    Advanced age, diabetes, and chronic kidney disease not only increase the risk for ischaemic events in chronic coronary syndromes (CCS) but also confer a high bleeding risk during antiplatelet therapy. These special populations may warrant modification of therapy, especially among Asians, who have displayed characteristics that are clinically distinct from Western patients. Previous guidance has been provided regarding the classification of high-risk CCS and the use of newer-generation P2Y12 inhibitors (i.e. ticagrelor and prasugrel) after acute coronary syndromes (ACS) in Asia. The authors summarise evidence on the use of these P2Y12 inhibitors during the transition from ACS to CCS and among special populations. Specifically, they present recommendations on the roles of standard dual antiplatelet therapy, shortened dual antiplatelet therapy and single antiplatelet therapy among patients with coronary artery disease, who are either transitioning from ACS to CCS; elderly; or with chronic kidney disease, diabetes, multivessel coronary artery disease and bleeding events during therapy.
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