The importance of rapid ambulance response to emergency medical crises is undeniable. An early
access to advanced care is crucial to saving a life. Modern computerised call centre and the hospitalbased ambulance services are believed to enhance the quality of service delivery. However, whether
it will further reduce the ambulance response time is still debatable. A cross-sectional study was
conducted in June 2012 until July 2012 at three selected tertiary hospitals in Malaysia. The
ambulance response time was expressed in a median and interquartile range (IQR) and MannWhitney U test was used to determine the associations between types of ambulance and
computerised call centre system versus voice only. Wilcoxon Rank Sign Test was used to assess
the significance of means difference. A hospital-based ambulance had the median time of 0.19
minutes while community-based ambulance had the median time of 0.20 minutes (The Z score -
0.916, p-value - 0.360). The hospital with computer call centre had the median time of 0.19 minutes
while hospital without computer call centre had the median of 0.20 minutes (The Z score - 0.816, P
value - 0.414).The response time of hospital-based ambulance equipped with computerised call
centre system was comparable in three selected tertiary hospitals in Malaysia.
Leptospirosis is one of the most widespread re-emerging zoonoses in the world. Malaysia is known to
be an endemic country for human leptospirosis, with a case fatality rate of 2.11%, and an average annual
incidence rate of 7.80 cases per 100,000 individuals. This systematic review is conducted to determine
the effectiveness of antibiotic prophylaxis for leptospirosis among the adult populations who are highly
at risk of getting infected. A systematic search was performed for the relevant titles, abstracts and
keywords on PubMed, Scopus, Cochrane and Google Scholar from inception to November 2017 based
on the PICO strategy; which returned 126 studies. Screening of abstracts had shortlisted 19 studies and
data extraction was conducted for 8 studies which had been accepted after review of the full text. For
the evaluation of antibiotics prophylaxis effectiveness against leptospirosis, only trials and cohort studies
with risk ratio (RR) were selected. The articles were analyzed from the viewpoint of the dosage, adverse
effects, study settings and effectiveness of the antibiotic prophylaxis. Using fixed effects model, pooled
RR showed protective association between antibiotic prophylaxis use against the incidence of
leptospirosis (RR = 0.31; 95% CI: 0.20, 0.48). Antibiotic prophylaxis for leptospirosis had been shown
to be effective in preventing the incidence of the disease among high-risk populations and carries
minimal adverse effects. It is recommended that the practice of antibiotic prophylaxis for leptospirosis is
included in the standard protocol for leptospirosis prevention among people at high-risk, including
disaster response teams and patrons of eco-sports tourism activities; with the drug of choice being
doxycycline, either as a single 200 mg dose or weekly dose of 200 mg for the duration of exposure,
based on the setting, duration of event and resources available.