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  1. Barmou MM, Hussain SF, Abu Hassan MI
    Int Orthod, 2018 06;16(2):314-327.
    PMID: 29673688 DOI: 10.1016/j.ortho.2018.03.005
    AIM: The aim of the study was to assess the reliability and validity of cephalometric variables from MicroScribe-3DXL.

    MATERIALS AND METHODS: Seven cephalometric variables (facial angle, ANB, maxillary depth, U1/FH, FMA, IMPA, FMIA) were measured by a dentist in 60 Malay subjects (30 males and 30 females) with class I occlusion and balanced face. Two standard images were taken for each subject with conventional cephalometric radiography and MicroScribe-3DXL. All the images were traced and analysed. SPSS version 2.0 was used for statistical analysis with P-value was set at P<0.05.

    RESULTS: The results revealed a significant statistic difference in four measurements (U1/FH, FMA, IMPA, FMIA) with P-value range (0.00 to 0.03). The difference in the measurements was considered clinically acceptable. The overall reliability of MicroScribe-3DXL was 92.7% and its validity was 91.8%.

    CONCLUSION: The MicroScribe-3DXL is reliable and valid to most of the cephalometric variables with the advantages of saving time and cost. This is a promising device to assist in diverse areas in dental practice and research.

  2. Al Batran R, Al-Bayaty F, Al-Obaidi MM, Hussain SF, Mulok TZ
    Biomed Res Int, 2014;2014:724718.
    PMID: 25215291 DOI: 10.1155/2014/724718
    Epidemiologic evidence has demonstrated significant associations between atherosclerosis and Porphyromonas gingivalis (Pg). We had investigated the effect of andrographolide (AND) on atherosclerosis induced by Pg in rabbits. For experimental purpose, we separated thirty male white New Zealand rabbits into 5 groups. Group 1 received standard food pellets; Groups 2-5 were orally challenged with Pg; Group 3 received atorvastatin (AV, 5 mg/kg), and Groups 4-5 received 10 and 20 mg/kg of AND, respectively, over 12 weeks. Groups treated with AND showed significant decrease in TC, TG, and LDL levels (P<0.05) and significant increase in HDL level in the serum of rabbits. Furthermore, the treated groups (G3-G5) exhibited reductions in interleukins (IL-1β and IL-6) and C-reactive protein (CRP) as compared to atherogenicgroup (G2). The histological results showed that the thickening of atherosclerotic plaques were less significant in treated groups (G3-G5) compared with atherogenicgroup (G2). Also, alpha-smooth muscle actin (α-SMA) staining decreased within the plaques of atherogenicgroup (G2), while it was increased in treated groups (G3-G5). Lastly, groups treated with AV and AND (G3-G5) showed significant reduction of CD36 expression (P<0.05) compared to atherogenicgroup (G2). These results substantially proved that AND contain antiatherogenic activity.
  3. Masood Y, Masood M, Zainul NN, Araby NB, Hussain SF, Newton T
    PMID: 23443041 DOI: 10.1186/1477-7525-11-25
    The objectives for this study were to assess Oral Health Related Quality of Life (OHRQoL) in young people aged 15-25 who sought orthodontic treatment, and to measure the association between orthodontic treatment need (using the IOTN), sex, age and education level, and oral health related quality of life (OHRQoL).
  4. Lewison G, Hussain SF, Guo P, Harding R, Mukherji D, Sittah GA, et al.
    Ecancermedicalscience, 2020;14:1094.
    PMID: 33014136 DOI: 10.3332/ecancer.2020.1094
    Background and objectives: The 57 countries of the Organisation of Islamic Cooperation (OIC) are experiencing rapid increases in their burden of cancer. The First Ladies Against Cancer meeting at the 2016 OIC meeting in Istanbul committed to the importance of cancer control and the need for more evidence to support national cancer control planning (NCCP). Strong research systems are a crucial aspect of NCCP, but few data exist to support policy-makers across this political grouping.

    Methodology: We identified all cancer research papers from OIC countries in the Web of Science from 2008 to 2017 with a filter based on journal names and title words, with high precision and recall. We analysed the country outputs, the cancer sites investigated, the types of research, sources of funding and the citations to the papers.

    Results: There were 49,712 cancer research papers over this period. The leading countries in terms of output were Turkey, Iran, Egypt and Malaysia, but the most cited papers were from Qatar, Indonesia and Saudi Arabia. International collaboration was low, except in Qatar and the United Arab Emirates. The site-specific cancers accounting for most research were breast and blood, correlating with their disease burden in the OIC countries, but lung, cervical and oesophageal cancers were relatively under-researched. Most funding from within the OIC countries was from their own university sector.

    Conclusion: Cancer is seriously under-researched in most of the OIC countries. This will undermine the ability of these countries and OIC as a whole to deliver on better cancer control for their populations. New policies, OIC leadership and funding are urgently needed to address this situation.

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