In many developing countries, including Nigeria, incineration of hospital waste remains a major waste treatment option, yet it is a significant factor contributing to occupational exposure to heavy metal emissions. This study investigated the concentration of selected heavy metals in blood plasma of workers that are occupationally exposed to hospital waste incinerator emissions in Federal Teaching Hospital, Ido-Ekiti, Ekiti State, Nigeria. Sixty-four (64) venous blood samples were collected and analyzed. Forty-two (42) were the exposed group and twenty-two (22) were the non-exposed group. The mean concentration of metals in blood plasma followed the order Fe > Cu > Cr > Zn > Cd > Ni > Co > As > Pb > Hg. There exists a significance difference (p