Cu doped InVO4 (xCu-InVO4 (x = 0.06-0.15 wt %) was synthesized by a facile one-pot hydrothermal method for the removal of methylene blue (MB) under LED light irradiation. The X-ray photoelectron spectroscopy (XPS) analysis indicated the coexistence of V5+ and V4+ species due to the O-deficient nature of the xCu-InVO4. The synthesized photocatalysts displayed a morphology of spherical and square shaped particles (20-40 nm) and micro-sized rectangle rods with a length range of 100-200 μm. The xCu-InVO4 exhibited superior adsorption and photodegradation efficiency compared to pristine InVO4 and TiO2 due to the presence of O2 vacancies, V4+/V5+ species, and Cu dopant. The optimum reaction conditions were found to be 5 mg L-1 (MB concentration), pH 6, and 100 mg of photocatalyst mass with a removal efficiency and mineralization degree of 100% and 96.67%, respectively. The main active species responsible for the degradation of MB were •OH radicals and h+. Reusability studies indicated that the 0.13Cu-InVO4 was deactivated after a single cycle of photocatalytic reaction due to significant leaching of V4+ and Cu2+ species.