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  1. Fulltext Plasma and CSF neurofilament light chain distinguish neurodegenerative from primary psychiatric conditions in a clinical setting
    Eratne D, Kang MJY, Lewis C, Dang C, Malpas CB, Keem M, et al.
    Alzheimers Dement, 2024 Nov;20(11):7989-8001.
    PMID: 39369278 DOI: 10.1002/alz.14278
    INTRODUCTION: People with neurodegenerative disorders (ND) frequently face diagnostic delay and misdiagnosis. We investigated blood and cerebrospinal fluid (CSF) neurofilament light chain (NfL) to distinguish ND from primary psychiatric disorders (PPD), a common challenge in clinical settings.

    METHODS: Plasma and CSF NfL levels were measured and compared between groups, adjusting for age, sex, and weight.

    RESULTS: A total of 337 participants were included: 136 ND, 77 PPD, and 124 Controls. Plasma NfL was 2.5-fold elevated in ND compared to PPD and had strong diagnostic performance (area under the curve, [AUC]: 0.86, 81%/85% specificity/sensitivity) that was comparable to CSF NfL (2-fold elevated, AUC: 0.89, 95%/71% specificity/sensitivity). Diagnostic performance was especially strong in younger people (40- 

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