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  1. Re-irradiation for children with diffuse intrinsic pontine glioma and diffuse midline glioma
    Shariff N, Moreno AS, Bennett J, Ramaswamy V, Das A, Liu AP, et al.
    Radiother Oncol, 2025 Mar 24.
    PMID: 40139463 DOI: 10.1016/j.radonc.2025.110865
    BACKGROUND AND PURPOSE: Diffuse intrinsic pontine glioma (DIPG) and diffuse midline glioma (DMG) are incurable brain malignancies. In this study, we report one of the largest known single-institution cohorts of DIPG/DMG patients undergoing re-irradiation (RT2) to evaluate its effect on survival.

    MATERIALS AND METHODS: Children aged less than 18 years treated for DIPG/DMG with initial fractionated photon radiotherapy (RT1) and had subsequent recurrence were retrospectively reviewed. Patients treated with or without RT2 were compared. The primary outcomes were overall survival (OS) from time of recurrence after RT1, and from start of RT2 (for the RT2 group).

    RESULTS: A total of 118 children were included, 39 of whom received RT2. Children treated with RT2 had superior OS, with 6-month OS of 66 % vs 22 % in those who did not undergo RT2 (p 

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