Globally, COVID-19 outbreak is a major social issue in the current trend. SARS-CoV2 is a novel coronavirus causing Severe Acute Respiratory Syndrome in human and it is spreading rapidly among human population. In order to prevent SARS-CoV2 infection and managing this corona disease, WHO formula based alcoholic hand sanitisers are being widely used as one of the primary preventive agent and the demand is increasing worldwide. Herbal extracts and/or their phytochemicals have been considered as natural sources for formulating herbal hand sanitizers as alternative to alcoholic products. In this correspondence, we have described about the probable mechanistic action of herbal bioactives to fight against COVID-19 virus. Understanding of mechanistic action of bioactives could be useful to formulate herbal hand sanitizers and the products have high demand in the global sanitizer market.