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  1. Fulltext Protective effects of Centella asiatica extract on spatial memory and learning deficits in animal model of systemic inflammation induced by lipopolysaccharide
    Md Pisar M, Chee BJ, Long I, Osman A
    Ann Med, 2023 Dec;55(1):2224970.
    PMID: 37318144 DOI: 10.1080/07853890.2023.2224970
    BACKGROUND AND AIM: Centella asiatica (L.) Urb. (Apiaceae) is a renowned medicinal plant being used in the Ayurvedic system for its pharmacological effects on the central nervous system such as rejuvenating, sedative, anxiolytic and memory-enhancing properties. The present study was designed to investigate the effect of Centella asiatica (CA) extract on inflammatory responses induced by lipopolysaccharide (LPS) and resulting changes in cognitive behavior.

    MATERIALS AND METHODS: Adult male Sprague-Dawley rats were divided into 4 groups as control, LPS, CA and LPS + CA. The treatments with LPS (5 mg/kg) were intraperitoneally (i.p) injected on day 4 and CA ethanol extract (200 mg/kg) were given orally for 14 days. Morris Water Maze (MWM) test was performed to assess spatial learning and memory performance. Acute oral toxicity of the extract at the highest dose of 5000 mg/kg was also conducted.

    RESULTS: Single administration of LPS was able to significantly elicit learning and memory impairment (p 

  2. Hydrophobization of nanofibrillated cellulose from Macaranga gigantea for binding of curcumin
    Jamaluddin NAN, Jasmani L, Md Pisar M, Adnan S, Rusli R, Zakaria S
    Carbohydr Polym, 2024 Oct 15;342:122405.
    PMID: 39048240 DOI: 10.1016/j.carbpol.2024.122405
    Nanofibrillated cellulose (NFC) has found extensive potential and existing utilizations across various industries. Nonetheless, a notable constraint of NFC lies in its inherent hydrophilic nature, which restricts its suitability for non-aqueous application. This study aims at synthesising hydrophobic NFC through a two-step surface modification by reacting NFC with tannic acid and amine group. The study also investigated the effect of using various alkylamines on the properties of modified NFC. The hydrophobic NFC was characterized using various analytical techniques namely Thermogravimetric Analysis (TGA), X-Ray Diffraction analysis (XRD), Atomic Force Microscopy (AFM), Fourier Transform Infrared Spectroscopy (FTIR), elemental analysis, and contact angle measurements. The present study also looked into the possible use of modified NFC as a pharmaceutical excipient for the delivery of water insoluble curcumin. The analysis of curcumin binding onto the modified NFC was conducted using UV-Visible spectrophotometry. The findings from the study indicated that the modified NFC effectively bound a substantial quantity of curcumin (80 % - 87 %) and the binding varied for samples of different degree of substitution.
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