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  1. Fulltext Game theory and evolutionary optimization approaches applied to resource allocation problems in computing environments: A survey
    Shamshirband S, Joloudari JH, Shirkharkolaie SK, Mojrian S, Rahmani F, Mostafavi S, et al.
    Math Biosci Eng, 2021 Oct 25;18(6):9190-9232.
    PMID: 34814342 DOI: 10.3934/mbe.2021453
    Today's intelligent computing environments, including the Internet of Things (IoT), Cloud Computing (CC), Fog Computing (FC), and Edge Computing (EC), allow many organizations worldwide to optimize their resource allocation regarding the quality of service and energy consumption. Due to the acute conditions of utilizing resources by users and the real-time nature of the data, a comprehensive and integrated computing environment has not yet provided a robust and reliable capability for proper resource allocation. Although traditional resource allocation approaches in a low-capacity hardware resource system are efficient for small-scale resource providers, for a complex system in the conditions of dynamic computing resources and fierce competition in obtaining resources, they cannot develop and adaptively manage the conditions optimally. To optimize the resource allocation with minimal delay, low energy consumption, minimum computational complexity, high scalability, and better resource utilization efficiency, CC/FC/EC/IoT-based computing architectures should be designed intelligently. Therefore, the objective of this research is a comprehensive survey on resource allocation problems using computational intelligence-based evolutionary optimization and mathematical game theory approaches in different computing environments according to the latest scientific research achievements.
  2. Fulltext Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression
    Glanville KP, Coleman JRI, Hanscombe KB, Euesden J, Choi SW, Purves KL, et al.
    Biol Psychiatry, 2020 Mar 01;87(5):419-430.
    PMID: 31570195 DOI: 10.1016/j.biopsych.2019.06.031
    BACKGROUND: The prevalence of depression is higher in individuals with autoimmune diseases, but the mechanisms underlying the observed comorbidities are unknown. Shared genetic etiology is a plausible explanation for the overlap, and in this study we tested whether genetic variation in the major histocompatibility complex (MHC), which is associated with risk for autoimmune diseases, is also associated with risk for depression.

    METHODS: We fine-mapped the classical MHC (chr6: 29.6-33.1 Mb), imputing 216 human leukocyte antigen (HLA) alleles and 4 complement component 4 (C4) haplotypes in studies from the Psychiatric Genomics Consortium Major Depressive Disorder Working Group and the UK Biobank. The total sample size was 45,149 depression cases and 86,698 controls. We tested for association between depression status and imputed MHC variants, applying both a region-wide significance threshold (3.9 × 10-6) and a candidate threshold (1.6 × 10-4).

    RESULTS: No HLA alleles or C4 haplotypes were associated with depression at the region-wide threshold. HLA-B*08:01 was associated with modest protection for depression at the candidate threshold for testing in HLA genes in the meta-analysis (odds ratio = 0.98, 95% confidence interval = 0.97-0.99).

    CONCLUSIONS: We found no evidence that an increased risk for depression was conferred by HLA alleles, which play a major role in the genetic susceptibility to autoimmune diseases, or C4 haplotypes, which are strongly associated with schizophrenia. These results suggest that any HLA or C4 variants associated with depression either are rare or have very modest effect sizes.

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