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  1. Muthukrishnan S, Tey DKH, Wee WC
    Data Brief, 2025 Feb;58:111309.
    PMID: 39911272 DOI: 10.1016/j.dib.2025.111309
    The dataset demonstrates the efficacy of Aqua Ectogon-284, a zinc chelates of glycine, as a dietary supplement to enhance growth and survival in hybrid grouper (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂) and whiteleg shrimp (Penaeus vannamei). Two concentrations (1g/kg feed and 2g/kg feed) were evaluated against a control group to identify an optimal dosage that maximizes growth and health outcomes. Both the species exhibited improved growth performance and survival rates with dietary supplementation. The hybrid grouper fed a 1g/kg diet achieved the highest final weight of 100.00 g, with significant increases in length and survival rates of 96.00%. Similarly, whiteleg shrimp demonstrated enhanced final weights and survival (94.67%) with the same treatment. These findings revealed that zinc chelate glycine increased the growth rate and reduced mortality in farmed species.
  2. Abd Ghafar SZ, Muthukrishnan S, Zolkeflee NKZ, Natrah I, Abas F
    Chem Biodivers, 2024 Dec 01.
    PMID: 39617725 DOI: 10.1002/cbdv.202402282
    The UHPLC-MS/MS metabolomics approach was employed to profile and characterize multi-components in Halamphora sp. extracted with different solvents that contribute to quorum sensing inhibitory (QSI) activity. A total of 37 and 34 metabolites were tentatively identified from negative and positive ion modes, respectively. The metabolites have been assigned to various groups, including fatty acids, glycolipids, sterols, diazines, flavonoids, peptides, carotenoids, and pigments. Multivariate data analysis showed that the QSI activity in the acetone extract was due to tumonoic acid A, terpeptin derivatives, pheophorbide A, hydroxyhexadeca-1,5-dien-3-ynoxy]propane-1,2-diol, l-methionyl-l-tyrosine, stearidonic, hexadecadienoic, tricosenoic, palmitic, and linolenic acids. These metabolites were more concentrated and differed significantly in acetone extract compared to other extracts. Acetone extract displayed a cluster of nodulisporic acid and fucoxanthin through MS/MS-based molecular networking (MN) platform. The present study shows that the liquid chromatography mass spectrometry (LCMS)-based metabolomics and MN effectively identify QSI-active metabolites in Halamphora sp. extracts, which can be promoted as a natural antifoulant.
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