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Colorimetric strategies applicable for loop-mediated isothermal amplification

Saifuddin SA, Rashid R, Nor Azmi NJ, Mohamad S

J Microbiol Methods, 2024 Aug;223:106981.
PMID: 38945305 DOI: 10.1016/j.mimet.2024.106981

In recent years, loop-mediated isothermal amplification (LAMP) has gained popularity for detecting various pathogen-specific genes due to its superior sensitivity and specificity compared to conventional polymerase chain reaction (PCR). The simplicity and flexibility of naked-eye detection of the amplicon make LAMP an ideal rapid and straightforward diagnostic tool, especially in resource-limited laboratories. Colorimetric detection is one of the simplest and most straightforward among all detection methods. This review will explore various colorimetric dyes used in LAMP techniques, examining their reaction mechanisms, advantages, limitations and latest applications.
Fulltext Risk factors and approaches for detection of Trichomonas tenax, the silent culprit in periodontal disease: A narrative review

Nor Azmi NJ, Mohamad S, Shahidan WNS, Taib H, Mohamed Z, Osman E

Saudi Dent J, 2024 Feb;36(2):258-261.
PMID: 38419993 DOI: 10.1016/j.sdentj.2023.11.014

INTRODUCTION: Periodontal disease is the inflammation of the periodontium tissues surrounding the teeth, potentially leading to loss of tooth attachment. In individuals with periodontal disease, the presence of Trichomonas tenax, a parasitic protozoan of the oral cavity has been observed and its frequency tends to rise as the disease progresses.
METHODS: A literature search was conducted in the online databases of PubMed, Google Scholar, Web of Science, and Scopus using the combination of keywords: "Trichomonas tenax" AND "periodontal disease" OR "gum disease", OR "oral disease" OR "periodontitis". A total of 9 articles satisfied the inclusion criteria and were included in this study.
RESULTS: This review highlights the incidence of T. tenax with periodontal diseases, the risk factors that contribute to the infection of T. tenax and available detection methods for the identification of the protozoan.
CONCLUSION: The inhabitation of the oral cavity by T. tenax prospers with the severity of periodontal diseases. Extensive research should be conducted to fully understand the potential pathogenic role and damaging effect of T. tenax in the oral cavity.

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