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  1. Fulltext High-risk cutaneous squamous cell carcinoma (CSCC): Challenges and emerging therapies
    Halim AS, Ramasenderan N
    Asian J Surg, 2023 Jan;46(1):47-51.
    PMID: 35545474 DOI: 10.1016/j.asjsur.2022.04.079
    Cutaneous squamous cell carcinoma (CSCC) is a common type of skin malignancy that affects people who have been exposed to sunlight for a long time. It has been associated to a high mutational load, making treatment problematic, especially for individuals with high-risk CSCC characteristics. Patients with high-risk CSCC are difficult to define since definitions are still imprecise. Firstly, we review the evidence to see how relevant locoregional involvement is in terms of patient survival and recurrence risk. Second, we go through the difficulties and obstacles that come with sentinel lymph node biopsy (SLNB) and their importance in the management of locally progressed CSCC. Methods and findings from a variety of lymph node investigations are described. There is yet no empirical evidence for the involvement of SLNB in CSCC. Finally, we discussed the most recent developments in the treatment of CSCC. The mainstays of treatment are surgery and radiation. To slow the disease progression, cancer medicines have switched to disrupting particular signaling pathways. Advanced nations have more easily accessible drugs like Cetuximab (epidermal growth factor receptor inhibitor) and Cemiplimab (anti-programme receptor-1 antibodies), which are utilized in advanced CSCC. The response rate varies based on the patient, although there is still a lack of proof. This article discusses the misconception that CSCC is a tumor with a favorable prognosis, as well as the difficulties in treating high-risk CSCC.
  2. Fulltext A synchronous incidence of eccrine porocarcinoma of the forearm and facial squamous cell carcinoma: A case report
    Ramasenderan N, Shahir H, Omar SZ
    Int J Surg Case Rep, 2018;42:116-120.
    PMID: 29245095 DOI: 10.1016/j.ijscr.2017.11.066
    INTRODUCTION: Cutaneous appendageal tumor can differentiate towards or arise from either pilosebaceous apparatus or the eccrine sweat glands. Appendageal tumors are relatively rare, their clinical appearance is non-specific, and the vast majority are not diagnosed until after excision. Eccrine porocarcinoma (EP), also known as malignant eccrine poroma is a rare adnexal tumor arising from the intraepithelial ductal parts of the sweat gland.

    CASE PRESENTATION: We presented a 65-year-old, Asian, female with medical co-morbids, who came with both a facial squamous cell carcinoma and a long-standing lesion over her left forearm. Histopathological finding of the left forearm demonstrated eccrine porocarcinoma.

    CONCLUSION: Mohs micrographic surgery is the mainstay treatment of cutaneous carcinoma. It is important to rule out associated syndromes in patient who present with multiple cutaneous appendageal tumors.

  3. Impact of COVID-19 on Plastic and Reconstructive Surgery Practice-Comparing Malaysia and Other Asian Countries: A Preliminary Study
    Ramasenderan N, Mohd Hussain MSB, Halim AS
    Asia Pac J Public Health, 2021 07;33(5):657-659.
    PMID: 33998307 DOI: 10.1177/10105395211014972
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