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  1. Gopalakrishnan, V., Thyagrajan, S.P.
    MyJurnal
    The worlds land and sea represent a limitless reserve of natural, biological and potentially
    active useful pharmaceutical products. Renewed interest in drugs from natural reserves,
    advances in chemical separation and analysis have identified hundreds of unique exotic
    physiologically active substances with antimicrobial, anti-tumor and other potentialities
    more rapidly, from terrestrial plants, marine flora and various classes of marine fauna.
    Development of practical and rapid methods for detection of plant products with activity
    against infectious disease producing organisms is the need of the hour. Rapid assays for
    antiviral studies using isotopic reverse transcriptase, E. coli DNA polymerase and HBV
    DNA polymerase inhibition assays were standardized. Extracts of marine flora and fauna
    collected under the DOD National project were assessed. Of the extracts assessed for virus
    specific enzyme inhibitions, 24.35% possessed RT inhibition activity, 15.83% E. coli
    DNA polymerase Inhibition activity, 42.72% of 35 extracts tested possessed HBV DNA
    polymerase inhibition activity and 11.42% of 35 extracts tested possessed inhibition
    activity against all three enzymes tested. The great potential of ocean’s flora and fauna is
    there to be used for its antimicrobial activity in general and antiviral activity in particular,
    which will suit our ever increasing need, is to be harnessed for the welfare of the human
    community at large.
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