This paper presented a review of the literature on the human thermal comfort model, which can be employed to predict the response of a human towards the environmental surroundings. An important premise of this paper is that governments in tropical regions have taken proactive action in minimizing energy consumption by air-conditioning through elevated room temperature. However, would such an action worsen the quality of interior conditions, particularly the thermal comfort? To answer this question, developing a human thermal comfort model under stratum ventilation mode can become a reference model for air-conditioning system design in all tropical buildings and indirectly reduce the emission of carbon dioxide (CO2) from heating, ventilation, and air-conditioning (HVAC) system that caused a warmer environment. For this purpose, there are two critical processes to identify the role of human thermal comfort, namely human reaction towards the thermal ambient (thermoregulation) and the heat transfer and air movement that occur in the enclosed space due to natural and forced convection.