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  1. Left bundle branch area pacing for heart failure patients requiring cardiac resynchronization therapy: A meta-analysis
    Jin C, Dai Q, Li P, Lam P, Cha YM
    J Cardiovasc Electrophysiol, 2023 Sep;34(9):1933-1943.
    PMID: 37548113 DOI: 10.1111/jce.16013
    INTRODUCTION: Left bundle branch area pacing (LBBP) is a novel conduction system pacing method to achieve effective physiological pacing and an alternative to cardiac resynchronization therapy (CRT) with biventricular pacing (BVP) for patients with heart failure with reduced ejection fraction (HFrEF). We conduted this meta-analysis and systemic review to review current data comparing BVP and LBBP in patients with HFrEF and indications for CRT.

    METHODS: We searched PubMed/Medline, Web of Science, and Cochrane Library from the inception of the database to November 2022. All studies that compared LBBP with BVP in patients with HFrEF and indications for CRT were included. Two reviewers performed study selection, data abstraction, and risk of bias assessment. We calculated risk ratios (RRs) with the Mantel-Haenszel method and mean difference (MD) with inverse variance using random effect models. We assessed heterogeneity using the I2 index, with I2  > 50% indicating significant heterogeneity.

    RESULTS: Ten studies (9 observational studies and 1 randomized controlled trial; 616 patients; 15 centers) published between 2020 and 2022 were included. We observed a shorter fluoroscopy time (MD: 9.68, 95% confidence interval [CI]: 4.49-14.87, I2  = 95%, p 

    Matched MeSH terms: Bundle of His
  2. Conduction abnormalities in thyrotoxicosis--a report of three cases
    Yusoff K, Khalid BA
    Ann Acad Med Singap, 1993 Jul;22(4):609-12.
    PMID: 8257070
    Cardiac arrhythmias are common in patients with thyrotoxicosis. Conduction abnormalities have been seen in a few thyrotoxic patients, but these, in particular high grade atrioventricular (AV) block, often occur in the presence of other conditions. Three thyrotoxic patients with conduction abnormalities are described: two were associated with severe hypokalaemia and the third had congestive cardiac failure. Conditions predisposing to conduction abnormality should be identified when this occurs in a thyrotoxic patient as their correction may help resolve or explain the conduction abnormality.
    Matched MeSH terms: Bundle of His/physiopathology
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