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Tumour lysis syndrome in a neonate with transient abnormal myelopoiesis

Mohammad Khuzaini A, Mohd Baharudin JA, Md Fauzi A, Zulkeflee HA, Abdul Halim H, Mazli SK, et al.

J Neonatal Perinatal Med, 2024;17(2):269-273.
PMID: 38728206 DOI: 10.3233/NPM-230146

BACKGROUND: Tumor lysis syndrome (TLS) is an oncological emergency associated with hematological malignancies or highly proliferative solid tumors, commonly after chemotherapy. It is rarely associated with transient abnormal myelopoiesis.
OBSERVATION: We report a rare case of a neonate with transient abnormal myelopoiesis and tumor lysis syndrome, complicated with concomitant heart failure due to an underlying atrioventricular septal defect. Hyperhydration was contraindicated due to heart failure. The patient was managed conservatively with full recovery.
CONCLUSION: Tumor lysis syndrome should be suspected in neonates with transient abnormal myelopoiesis with electrolyte abnormalities. Treatment options should be considered carefully for their risks and benefits.

Matched MeSH terms: Heart Septal Defects, Atrial/diagnosis
Use of non-invasive phase contrast magnetic resonance imaging for estimation of atrial septal defect size and morphology: a comparison with transesophageal echo

Piaw CS, Kiam OT, Rapaee A, Khoon LC, Bang LH, Ling CW, et al.

Cardiovasc Intervent Radiol, 2006 Mar-Apr;29(2):230-4.
PMID: 16252078

Transesophageal echocardiography (TEE) is a trusted method of sizing atrial septal defect (ASD) prior to percutaneous closure but is invasive, uncomfortable, and may carry a small risk of morbidity and mortality. Magnetic resonance imaging (MRI) may be useful non-invasive alternative in such patients who refuse or are unable to tolerate TEE and may provide additional information on the shape of the A0SD.

Matched MeSH terms: Heart Septal Defects, Atrial/diagnosis*

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