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  1. Fulltext Association between subclinical hypothyroidism and depression: an updated systematic review and meta-analysis
    Loh HH, Lim LL, Yee A, Loh HS
    BMC Psychiatry, 2019 01 08;19(1):12.
    PMID: 30621645 DOI: 10.1186/s12888-018-2006-2
    BACKGROUND: Although depression is associated with changes in the hypothalamic-pituitary-thyroid axis, its relationship with subclinical hypothyroidism (SCH) is controversial. To date, there is a lack of data on the improvement of depressive symptoms with levothyroxine therapy among individuals with coexistent SCH.

    METHODS: We conducted a meta-analysis to evaluate the association between SCH and depression including 1) the prevalence of depression in SCH (with a sub-analysis of the geriatric cohort), 2) thyroid stimulating hormone (TSH) level among patients with depression and 3) the effect of levothyroxine therapy among patients with SCH and coexistent depression.

    RESULTS: In a pooled analysis of 12,315 individuals, those with SCH had higher risk of depression than euthyroid controls (relative risk 2.35, 95% confidence intervals [CI], 1.84 to 3.02; p 

    Matched MeSH terms: Hypothyroidism/psychology*
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