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  1. RamaChandran S, Ariffin H
    Pediatr Blood Cancer, 2009 Sep;53(3):488-90.
    PMID: 19434733 DOI: 10.1002/pbc.22063
    Haemophagocytic lymphohistiocytosis (HLH) is an uncommon disease with a high fatality rate. Etoposide is an important component of current HLH treatment regimes. Two patients with HLH developed etoposide-related secondary acute myeloid leukemia (sAML) following therapy for HLH. Etoposide, an epipodophyllotoxin, is a topoisomerase II inhibitor that interacts with DNA to potentiate leukaemogenesis. The risk of developing sAML is estimated to be between 1% and 5%, 2-20 years after exposure to etoposide but may also be related to cumulative drug doses, treatment schedules, host factors and co-administration of other antineoplastic agents.
    Matched MeSH terms: Neoplasms, Second Primary/chemically induced*
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