Evaluation of TNF-α and IL-6 in saliva among diabetic retinopathy patients in East Coast Malaysia

Khairul-Anwar I 1 , Wan-Nazatul-Shima S 2 , Siti-Lailatul-Akmar Z 3 , Siti-Azrin AH 4 , Zunaina E 1

Affiliations 

  • 1 Department of Ophthalmology and Visual Science, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Malaysia
  • 2 Basic Science & Oral Biology Unit, School of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Malaysia
  • 3 Department of Periodontics, School of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Malaysia
  • 4 Biostatistics and Research Methodology Unit, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Malaysia
Trop Med Int Health, 2022 Jan 19.
PMID: 35048479 DOI: 10.1111/tmi.13724

Abstract

OBJECTIVE: To compare tumour necrosis factor-alpha (TNF) and interleukin (IL)-6 levels in saliva between different stages of diabetic retinopathy (DR).

METHODS: This comparative cross-sectional study was conducted between January 2018 and November 2020. This study included diabetes mellitus (DM) patients with no DR, non-proliferative DR (NPDR), and proliferative DR (PDR). None of the patients with DM were included in the control group. Unstimulated saliva samples were then collected. TNF-α and IL-6 levels were measured.

RESULTS: Altogether, 120 patients were included in the study (DM without DR, 33 patients; DM with NPDR, 30 patients; DM with PDR, 32 patients; non-DM, 25 patients). The mean IL-6 level in saliva was significantly higher in the DM group (0.033 ± 0.005 pg/ml) than in the non-DM group (0.027 ± 0.001 pg/ml) (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Similar publications