Mechanistic insights into the beneficial effects of curcumin on insulin resistance: Opportunities and challenges

Balakumar P 1 , Venkatesan K 2 , Abdulla Khan N 3 , Raghavendra NM 4 , Venugopal V 5 , Bharathi DR 6 Show all authors , Fuloria NK 7

Affiliations 

  • 1 The Office of Research and Development, Periyar Maniammai Institute of Science & Technology (Deemed to be University), Vallam, Thanjavur 613 403, Tamil Nadu, India. Electronic address: pbala2006@gmail.com
  • 2 Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Al-Qara, Abha 61421, Saudi Arabia
  • 3 Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Al-Qara, Abha 61421, Saudi Arabia
  • 4 Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru 560 111, India
  • 5 School of Pharmacy, Sri Balaji Vidyapeeth Deemed-to-be University, Puducherry 607 402, India
  • 6 Department of Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B G Nagara, Nagamangala 571 448, India
  • 7 Pharmaceutical Chemistry Unit, Faculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Malaysia
Drug Discov Today, 2023 Jul;28(7):103627.
PMID: 37224995 DOI: 10.1016/j.drudis.2023.103627

Abstract

The past couple of decades in particular have seen a rapid increase in the prevalence of type 2 diabetes mellitus (T2DM), a debilitating metabolic disorder characterised by insulin resistance. The insufficient efficacy of current management strategies for insulin resistance calls for additional therapeutic options. The preponderance of evidence suggests potential beneficial effects of curcumin on insulin resistance, while modern science provides a scientific basis for its potential applications against the disease. Curcumin combats insulin resistance by increasing the levels of circulating irisin and adiponectin, activating PPARγ, suppressing Notch1 signalling, and regulating SREBP target genes, among others. In this review, we bring together the diverse areas pertaining to our current understanding of the potential benefits of curcumin on insulin resistance, associated mechanistic insights, and new therapeutic possibilities.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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